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学科主题: 临床医学
题名:
The prevalence of left ventricular hypertrophy in Chinese hemodialysis patients is higher than that in peritoneal dialysis patients
作者: Tian, Jun-Ping1; Wang, Tao2; Wang, Hong3; Cheng, Li-Tao2; Tian, Xin-Kui2; Lindholm, Bengt1; Axelsson, Jonas1; Du, Feng-He1
关键词: peritoneal dialysis ; hemodialysis ; left ventricular hypertrophy ; volume ; hemodynamics
刊名: RENAL FAILURE
发表日期: 2008
DOI: 10.1080/08860220801964178
卷: 30, 期:4, 页:391-400
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Urology & Nephrology
研究领域[WOS]: Urology & Nephrology
关键词[WOS]: STAGE RENAL-DISEASE ; ARTERIOVENOUS-FISTULA CLOSURE ; LONG-TERM CAPD ; FOLLOW-UP ; TRANSPLANT RECIPIENTS ; SURVIVAL ; VOLUME ; HYPERTENSION ; ASSOCIATION ; THERAPY
英文摘要:

Background. Left ventricular hypertrophy (LVH) is common in dialysis patients, and an independent predictor of mortality. While recent studies have shown no differences in mortality between the two most common dialysis modalities, hemodialysis (HD) and peritoneal dialysis (PD), their impact on LVH is controversial. We thus performed cardiac ultrasound studies in prevalent dialysis patients receiving either HD or PD and compared LVH. Methods. We included 48 HD and 62 PD patients receiving treatment for at least three months in our dialysis center. All patients underwent echocardiographic examination and blood pressure measurements immediately following therapy. Volume status was assessed by bioelectrical impedance analysis. Results. There was no baseline difference in demographics or comorbidities between HD and PD patients. As expected, extracellular water (ECW) in post-HD patients was significantly lower than that in pre-HD and PD patients, while cardiac output (CO) and systolic blood pressure (SBP) were higher in pre-HD than that in post-HD or PD patients. There was no significant difference in CO or SBP between post-HD and PD patients. Left ventricular mass index (LVMI) was markedly higher in HD patients as compared to PD patients. Thus, the prevalence of LVH according to the Framingham criteria was 68.8% in HD patients and 45.2% in PD patients. Subgroup analysis showed similar results in the patients who had been on single-modality dialysis for at least two years and in the anuric patients. Finally, in a linear regression model (r(2) = 0.364, p < 0.001), SBP, treatment modality (to be in HD), and ECW were all independent predictors of LVMI. Conclusions. In a cross-sectional analysis of prevalent Chinese patients, we found a higher LVMI and a higher prevalence of LVH in HD than in PD patients. As LVMI was associated with high blood pressure and volume overload, we suggest that in these patients, PD may preserve more physiological hemodynamics even during long-term therapy.

语种: 英语
WOS记录号: WOS:000256352500008
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/52109
Appears in Collections:北京大学第三临床医学院_肾内科_期刊论文

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作者单位: 1.Shanxi Fenyang Hosp, Dept Internal Med, Taiyuan, Shanxi, Peoples R China
2.Capital Med Univ, Beijing Tiantan Hosp, Div Cardiol, Beijing 100050, Peoples R China
3.Peking Univ, Div Nephrol, Hosp 3, Beijing 100871, Peoples R China
4.Karolinska Inst, Div Baxter Novum, Dept Clin Sci Intervent & Technol, Stockholm, Sweden
5.Karolinska Inst, Div Renal Med, Dept Clin Sci Intervent & Technol, Stockholm, Sweden

Recommended Citation:
Tian, Jun-Ping,Wang, Tao,Wang, Hong,et al. The prevalence of left ventricular hypertrophy in Chinese hemodialysis patients is higher than that in peritoneal dialysis patients[J]. RENAL FAILURE,2008,30(4):391-400.
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