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学科主题: 药学
题名:
A minimal structural analogue of cyclic ADP-ribose - Synthesis and calcium release activity in mammalian cells
作者: Guse, AH1; Gu, XF1; Zhang, LR1; Weber, K1; Kramer, E1; Yang, ZJ1; Jin, HW1; Li, Q1; Carrier, L1; Zhang, LH1
刊名: JOURNAL OF BIOLOGICAL CHEMISTRY
发表日期: 2005-04-22
DOI: 10.1074/jbc.M414032200
卷: 280, 期:16, 页:15952-15959
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Biochemistry & Molecular Biology
研究领域[WOS]: Biochemistry & Molecular Biology
关键词[WOS]: RAT CARDIAC MYOCYTES ; ADENOSINE-DIPHOSPHORIBOSE CADPR ; RYANODINE RECEPTOR ; T-LYMPHOCYTES ; CA2+ SIGNALS ; STORES ; PHARMACOLOGY ; PROPAGATION ; METABOLITES ; MESSENGERS
英文摘要:

Cyclic ADP-ribose (cADPR) is an endogenous Ca2+-mobilizing second messenger in many cell types and organisms. Although the biological activity of several modified analogues of cADPR has been analyzed, most of these structures were still very similar to the original molecule. Recently, we have introduced simplified analogues in which the northern ribose (N-1-linked ribose) was replaced by an ether strand (Gu, X., Yang, Z., Zhang, L., Kunerth, S., Fliegert, R., Weber, K., Guse, A. H., and Zhang, L. ( 2004) J. Med. Chem. 47, 5674 - 5682). Here we also demonstrate that the southern ribose ( N-9-linked ribose) can be replaced by an ether strand resulting in N-1-[(phosphoryl-O-ethoxy)methyl]- N-9-[(phosphoryl-O-ethoxy)- methyl]-hypoxanthine-cyclic pyrophosphate (cIDP-DE). This minimal structural analogue of cyclic ADP-ribose released Ca2+ from intracellular stores of permeabilized Jurkat T lymphocytes. In intact T lymphocytes initial subcellular Ca2+ release events, global Ca2+ release, and subsequent global Ca2+ entry were observed. Cardiac myocytes freshly prepared from mice responded to cIDP-DE by increased recruitment of localized Ca2+ signals and by global Ca2+ waves.

语种: 英语
WOS记录号: WOS:000228444800061
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/52116
Appears in Collections:北京大学药学院_期刊论文

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作者单位: 1.INSERM, U582, F-75013 Paris, France
2.Univ Hamburg, Hosp Eppendorf, Ctr Med Expt, Inst Biochem & Mol Biol 1, D-20246 Hamburg, Germany
3.Univ Hamburg, Hosp Eppendorf, Ctr Med Expt, Inst Cellular Signal Transduct, D-20246 Hamburg, Germany
4.Univ Hamburg, Hosp Eppendorf, Ctr Med Expt, Dept Pharmacol, D-20246 Hamburg, Germany
5.Peking Univ, Sch Pharmaceut Sci, Natl Lab Nat & Biomimet Drugs, Beijing 100083, Peoples R China

Recommended Citation:
Guse, AH,Gu, XF,Zhang, LR,et al. A minimal structural analogue of cyclic ADP-ribose - Synthesis and calcium release activity in mammalian cells[J]. JOURNAL OF BIOLOGICAL CHEMISTRY,2005,280(16):15952-15959.
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