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A minimal structural analogue of cyclic ADP-ribose - Synthesis and calcium release activity in mammalian cells
Guse, AH1; Gu, XF1; Zhang, LR1; Weber, K1; Kramer, E1; Yang, ZJ1; Jin, HW1; Li, Q1; Carrier, L1; Zhang, LH1
刊名JOURNAL OF BIOLOGICAL CHEMISTRY
2005-04-22
DOI10.1074/jbc.M414032200
280期:16页:15952-15959
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Biochemistry & Molecular Biology
研究领域[WOS]Biochemistry & Molecular Biology
关键词[WOS]RAT CARDIAC MYOCYTES ; ADENOSINE-DIPHOSPHORIBOSE CADPR ; RYANODINE RECEPTOR ; T-LYMPHOCYTES ; CA2+ SIGNALS ; STORES ; PHARMACOLOGY ; PROPAGATION ; METABOLITES ; MESSENGERS
英文摘要

Cyclic ADP-ribose (cADPR) is an endogenous Ca2+-mobilizing second messenger in many cell types and organisms. Although the biological activity of several modified analogues of cADPR has been analyzed, most of these structures were still very similar to the original molecule. Recently, we have introduced simplified analogues in which the northern ribose (N-1-linked ribose) was replaced by an ether strand (Gu, X., Yang, Z., Zhang, L., Kunerth, S., Fliegert, R., Weber, K., Guse, A. H., and Zhang, L. ( 2004) J. Med. Chem. 47, 5674 - 5682). Here we also demonstrate that the southern ribose ( N-9-linked ribose) can be replaced by an ether strand resulting in N-1-[(phosphoryl-O-ethoxy)methyl]- N-9-[(phosphoryl-O-ethoxy)- methyl]-hypoxanthine-cyclic pyrophosphate (cIDP-DE). This minimal structural analogue of cyclic ADP-ribose released Ca2+ from intracellular stores of permeabilized Jurkat T lymphocytes. In intact T lymphocytes initial subcellular Ca2+ release events, global Ca2+ release, and subsequent global Ca2+ entry were observed. Cardiac myocytes freshly prepared from mice responded to cIDP-DE by increased recruitment of localized Ca2+ signals and by global Ca2+ waves.

语种英语
WOS记录号WOS:000228444800061
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被引频次:43[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/52116
专题北京大学药学院
作者单位1.INSERM, U582, F-75013 Paris, France
2.Univ Hamburg, Hosp Eppendorf, Ctr Med Expt, Inst Biochem & Mol Biol 1, D-20246 Hamburg, Germany
3.Univ Hamburg, Hosp Eppendorf, Ctr Med Expt, Inst Cellular Signal Transduct, D-20246 Hamburg, Germany
4.Univ Hamburg, Hosp Eppendorf, Ctr Med Expt, Dept Pharmacol, D-20246 Hamburg, Germany
5.Peking Univ, Sch Pharmaceut Sci, Natl Lab Nat & Biomimet Drugs, Beijing 100083, Peoples R China
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GB/T 7714
Guse, AH,Gu, XF,Zhang, LR,et al. A minimal structural analogue of cyclic ADP-ribose - Synthesis and calcium release activity in mammalian cells[J]. JOURNAL OF BIOLOGICAL CHEMISTRY,2005,280(16):15952-15959.
APA Guse, AH.,Gu, XF.,Zhang, LR.,Weber, K.,Kramer, E.,...&Zhang, LH.(2005).A minimal structural analogue of cyclic ADP-ribose - Synthesis and calcium release activity in mammalian cells.JOURNAL OF BIOLOGICAL CHEMISTRY,280(16),15952-15959.
MLA Guse, AH,et al."A minimal structural analogue of cyclic ADP-ribose - Synthesis and calcium release activity in mammalian cells".JOURNAL OF BIOLOGICAL CHEMISTRY 280.16(2005):15952-15959.
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