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学科主题: 药学
题名:
SOD-like activity of copper salicylate complex in tween micellar systems
作者: Liu, Y; Zhang, XD; Lu, CS
刊名: ACTA BIOCHIMICA ET BIOPHYSICA SINICA
发表日期: 1996
卷: 28, 期:1, 页:38-42
文章类型: Article
类目[WOS]: Biochemistry & Molecular Biology ; Biophysics
研究领域[WOS]: Biochemistry & Molecular Biology ; Biophysics
摘要: Copper salicylate-ethanol complex was synthesized and its composition was analysed. The four surfactants (Tween-20, Tween-40, Tween-60, Tween-80) were purified. Their critical micelle concentrations (CMC) in phosphate buffer (pH = 7.4) were measured. The SOD-like activity of copper salicylate complex was assayed using the cytochrome-e reduction method. The scavenging effects of the four surfactants on O-(radical anion)(2) and . OH were investigated. The cooperative effect of the complex with surfactants and micelles was studied in detail. An activity enhancement of the complex was observed in the presence of surfactants. The four surfactants themselves display SOD-Like activities to a certain extent. It was shown that the complex and the four surfactants have apparently positive cooperative actions and similar results were obtained in the experiment for anti-lipid peroxidation of red cell membrane. These results might be explained by the fact of micellar catalysis and the copper salicylate-Tween system was suggested to be used as antiinflammatory drugs.
语种: 日语
WOS记录号: WOS:A1996TZ41800006
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/5211
Appears in Collections:北京大学药学院_期刊论文

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作者单位: BEIJING MED UNIV,SCH PHARMACEUT SCI,BEIJING 100088,PEOPLES R CHINA
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