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学科主题: 精神卫生
题名:
Extract of Ginkgo biloba Treatment for Tardive Dyskinesia in Schizophrenia: A Randomized, Double-Blind, Placebo-Controlled Trial
作者: Zhang, Wu-Fang1; Tan, Yun-Long2; Zhang, Xiang-Yang2,4; Chan, Raymond C. K.3; Wu, Hao-Ran5; Zhou, Dong-Feng1
刊名: JOURNAL OF CLINICAL PSYCHIATRY
发表日期: 2011-05-01
DOI: 10.4088/JCP.09m05125yel
卷: 72, 期:5, 页:615-621
收录类别: SCI ; SSCI
文章类型: Article
WOS标题词: Social Sciences ; Science & Technology
类目[WOS]: Psychology, Clinical ; Psychiatry
研究领域[WOS]: Psychology ; Psychiatry
关键词[WOS]: VITAMIN-E TREATMENT ; CONTROLLED CROSSOVER ; ALZHEIMERS-DISEASE ; OXIDATIVE STRESS ; RAT-BRAIN ; EFFICACY ; HALOPERIDOL ; ANTIPSYCHOTICS ; METAANALYSIS ; DISORDERS
英文摘要:

Objective: Free radicals may be involved in the pathogenesis of tardive dyskinesia (TD). Extract of Ginkgo biloba (EGb) is a potent antioxidant possessing free radical-scavenging activities. The aim of the study was to evaluate the efficacy of EGb-761, a standardized extract given in capsule form, in treating TD in schizophrenia patients.

Method: Inpatients with DSM-IV-diagnosed schizophrenia and TD (n =157) in a mainland China Veterans Affairs psychiatric hospital were randomly assigned to 12 weeks of treatment with either EGb-761, 240 mg/d (n=78) or a placebo (n=79) in a double-blind manner. Primary outcome measures were (1) change from baseline in the Abnormal Involuntary Movement Scale (AIMS) score and (2) proportion of patients with a 30% reduction in their AIMS total score at week 12. Secondary outcome measures included the Positive and Negative Syndrome Scale (PANSS) and cognitive performance as measured by the Continuous Performance Test-37 Version and the 3-card Stroop task. Patients were recruited for the study between December 2006 and May 2007.

Results: Of the 157 patients who were randomly assigned, 152 (96.8%) completed the study. EGb-761 treatment significantly decreased the AIMS total score in patients with TD compared to those who were given a placebo (2.13 +/- 1.75 vs -0.10 +/- 1.69; P<.0001), with 40 (51.3%) and 4 (5.1%) patients achieving response in the EGb-761 and placebo treatment groups, respectively. There were no between-group differences in the PANSS total score or cognitive measures from baseline to week 12.

Conclusions: EGb-761 appears to be an effective treatment for reducing the symptoms of TD in schizophrenia patients, and improvement may be mediated through the well-known antioxidant activity of this extract.

语种: 英语
所属项目编号: 2007BC512307 ; 30870898
项目资助者: National Basic Research Program of China (973 Program) ; National Natural Science Foundation of China ; GlaxoSmithKline
WOS记录号: WOS:000291240600007
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/52123
Appears in Collections:北京大学精神卫生研究所_期刊论文

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作者单位: 1.Hebei Prov Rong Jun Hosp, Baoding, Peoples R China
2.Peking Univ, Inst Mental Hlth, Key Lab Mental Hlth, Minist Hlth, Beijing 100191, Peoples R China
3.Beijing Hui Long Guan Hosp, Ctr Biol Psychiat, Beijing 100096, Peoples R China
4.Chinese Acad Sci, Inst Psychol, Neuropsychol & Appl Cognit Neurosci Lab, Beijing 100101, Peoples R China
5.Baylor Coll Med, Dept Psychiat & Behav Sci, Houston, TX 77030 USA

Recommended Citation:
Zhang, Wu-Fang,Tan, Yun-Long,Zhang, Xiang-Yang,et al. Extract of Ginkgo biloba Treatment for Tardive Dyskinesia in Schizophrenia: A Randomized, Double-Blind, Placebo-Controlled Trial[J]. JOURNAL OF CLINICAL PSYCHIATRY,2011,72(5):615-621.
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