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Extract of Ginkgo biloba Treatment for Tardive Dyskinesia in Schizophrenia: A Randomized, Double-Blind, Placebo-Controlled Trial
Zhang, Wu-Fang1; Tan, Yun-Long2; Zhang, Xiang-Yang2,4; Chan, Raymond C. K.3; Wu, Hao-Ran5; Zhou, Dong-Feng1
刊名JOURNAL OF CLINICAL PSYCHIATRY
2011-05-01
DOI10.4088/JCP.09m05125yel
72期:5页:615-621
收录类别SCI ; SSCI
文章类型Article
WOS标题词Social Sciences ; Science & Technology
类目[WOS]Psychology, Clinical ; Psychiatry
研究领域[WOS]Psychology ; Psychiatry
关键词[WOS]VITAMIN-E TREATMENT ; CONTROLLED CROSSOVER ; ALZHEIMERS-DISEASE ; OXIDATIVE STRESS ; RAT-BRAIN ; EFFICACY ; HALOPERIDOL ; ANTIPSYCHOTICS ; METAANALYSIS ; DISORDERS
英文摘要

Objective: Free radicals may be involved in the pathogenesis of tardive dyskinesia (TD). Extract of Ginkgo biloba (EGb) is a potent antioxidant possessing free radical-scavenging activities. The aim of the study was to evaluate the efficacy of EGb-761, a standardized extract given in capsule form, in treating TD in schizophrenia patients.

Method: Inpatients with DSM-IV-diagnosed schizophrenia and TD (n =157) in a mainland China Veterans Affairs psychiatric hospital were randomly assigned to 12 weeks of treatment with either EGb-761, 240 mg/d (n=78) or a placebo (n=79) in a double-blind manner. Primary outcome measures were (1) change from baseline in the Abnormal Involuntary Movement Scale (AIMS) score and (2) proportion of patients with a 30% reduction in their AIMS total score at week 12. Secondary outcome measures included the Positive and Negative Syndrome Scale (PANSS) and cognitive performance as measured by the Continuous Performance Test-37 Version and the 3-card Stroop task. Patients were recruited for the study between December 2006 and May 2007.

Results: Of the 157 patients who were randomly assigned, 152 (96.8%) completed the study. EGb-761 treatment significantly decreased the AIMS total score in patients with TD compared to those who were given a placebo (2.13 +/- 1.75 vs -0.10 +/- 1.69; P<.0001), with 40 (51.3%) and 4 (5.1%) patients achieving response in the EGb-761 and placebo treatment groups, respectively. There were no between-group differences in the PANSS total score or cognitive measures from baseline to week 12.

Conclusions: EGb-761 appears to be an effective treatment for reducing the symptoms of TD in schizophrenia patients, and improvement may be mediated through the well-known antioxidant activity of this extract.

语种英语
WOS记录号WOS:000291240600007
项目编号2007BC512307 ; 30870898
资助机构National Basic Research Program of China (973 Program) ; National Natural Science Foundation of China ; GlaxoSmithKline
引用统计
被引频次:41[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/52123
专题北京大学精神卫生研究所
作者单位1.Hebei Prov Rong Jun Hosp, Baoding, Peoples R China
2.Peking Univ, Inst Mental Hlth, Key Lab Mental Hlth, Minist Hlth, Beijing 100191, Peoples R China
3.Beijing Hui Long Guan Hosp, Ctr Biol Psychiat, Beijing 100096, Peoples R China
4.Chinese Acad Sci, Inst Psychol, Neuropsychol & Appl Cognit Neurosci Lab, Beijing 100101, Peoples R China
5.Baylor Coll Med, Dept Psychiat & Behav Sci, Houston, TX 77030 USA
推荐引用方式
GB/T 7714
Zhang, Wu-Fang,Tan, Yun-Long,Zhang, Xiang-Yang,et al. Extract of Ginkgo biloba Treatment for Tardive Dyskinesia in Schizophrenia: A Randomized, Double-Blind, Placebo-Controlled Trial[J]. JOURNAL OF CLINICAL PSYCHIATRY,2011,72(5):615-621.
APA Zhang, Wu-Fang,Tan, Yun-Long,Zhang, Xiang-Yang,Chan, Raymond C. K.,Wu, Hao-Ran,&Zhou, Dong-Feng.(2011).Extract of Ginkgo biloba Treatment for Tardive Dyskinesia in Schizophrenia: A Randomized, Double-Blind, Placebo-Controlled Trial.JOURNAL OF CLINICAL PSYCHIATRY,72(5),615-621.
MLA Zhang, Wu-Fang,et al."Extract of Ginkgo biloba Treatment for Tardive Dyskinesia in Schizophrenia: A Randomized, Double-Blind, Placebo-Controlled Trial".JOURNAL OF CLINICAL PSYCHIATRY 72.5(2011):615-621.
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