IR@PKUHSC  > 北京大学第一临床医学院
学科主题临床医学
Connective tissue disease-associated pulmonary arterial hypertension in Chinese patients
Hao, Yan-Jie1; Jiang, Xin2,3; Zhou, Wei1; Wang, Yong4; Gao, Lan1; Wang, Yu1; Li, Guang-Tao1; Hong, Tao5; Huo, Yong5; Jing, Zhi-Cheng2,3; Zhang, Zhuo-Li1
刊名EUROPEAN RESPIRATORY JOURNAL
2014-10-01
DOI10.1183/09031936.00182813
44期:4页:963-972
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Respiratory System
研究领域[WOS]Respiratory System
关键词[WOS]SYSTEMIC-LUPUS-ERYTHEMATOSUS ; INTERSTITIAL LUNG-DISEASE ; HONG-KONG CHINESE ; TAKAYASU ARTERITIS ; CLINICAL CHARACTERISTICS ; RHEUMATIC-DISEASES ; REVISED CRITERIA ; SCLEROSIS ; SURVIVAL ; EPIDEMIOLOGY
英文摘要

We sought to investigate the characteristics, survival and risk factors for mortality in Chinese patients with connective tissue disease (CTD)-associated pulmonary arterial hypertension (APAH) in modern therapy era.

129 consecutive adult patients who visited one of three referral centres in China with a diagnosis of CTD-APAH confirmed by right heart catheterisation during the previous 5 years were enrolled. The end-point was all-cause death or data censoring.

Systemic lupus erythematosus was the most common underlying CTD (49%) and systemic sclerosis just accounted for 6% in this cohort. The overall survival at 1 and 3 years was 92% and 80%, respectively. Pericardial effusion, a shorter 6-min walk distance, lower mixed venous oxygen saturation, higher pulmonary vascular resistance (PVR) and alkaline phosphatase (ALP), and lower total cholesterol levels were all associated with a higher risk of death among the study population. Higher PVR and ALP were independent predictors of mortality.

In conclusion, unlike in western patients, systemic lupus erythematosus is the most common underlying disease in Chinese patients with CTD-APAH. The survival of Chinese patients with CTD-APAH in the modern treatment era is similar to that in western countries. Elevated PVR and ALP are independent risk factors for poor outcomes.

语种英语
WOS记录号WOS:000342543700020
引用统计
被引频次:24[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/52130
专题北京大学第一临床医学院
北京大学第一临床医学院_风湿免疫科
北京大学第一临床医学院_心血管内科
作者单位1.Peking Univ, Hosp 1, Dept Rheumatol & Clin Immunol, Beijing 100034, Peoples R China
2.Fu Wai Hosp, Peking Union Med Coll, Thrombosis & Vasc Med Ctr, State Key Lab Cardiovasc Dis, Beijing, Peoples R China
3.Chinese Acad Med Sci, Beijing 100730, Peoples R China
4.Capital Med Univ, Beijing Shijitan Hosp, Dept Pulm Vasc Dis, Beijing, Peoples R China
5.Peking Univ, Hosp 1, Dept Cardiol, Beijing 100034, Peoples R China
推荐引用方式
GB/T 7714
Hao, Yan-Jie,Jiang, Xin,Zhou, Wei,et al. Connective tissue disease-associated pulmonary arterial hypertension in Chinese patients[J]. EUROPEAN RESPIRATORY JOURNAL,2014,44(4):963-972.
APA Hao, Yan-Jie.,Jiang, Xin.,Zhou, Wei.,Wang, Yong.,Gao, Lan.,...&Zhang, Zhuo-Li.(2014).Connective tissue disease-associated pulmonary arterial hypertension in Chinese patients.EUROPEAN RESPIRATORY JOURNAL,44(4),963-972.
MLA Hao, Yan-Jie,et al."Connective tissue disease-associated pulmonary arterial hypertension in Chinese patients".EUROPEAN RESPIRATORY JOURNAL 44.4(2014):963-972.
条目包含的文件
条目无相关文件。
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[Hao, Yan-Jie]的文章
[Jiang, Xin]的文章
[Zhou, Wei]的文章
百度学术
百度学术中相似的文章
[Hao, Yan-Jie]的文章
[Jiang, Xin]的文章
[Zhou, Wei]的文章
必应学术
必应学术中相似的文章
[Hao, Yan-Jie]的文章
[Jiang, Xin]的文章
[Zhou, Wei]的文章
相关权益政策
暂无数据
收藏/分享
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。