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学科主题临床医学
Autonomic mechanism to explain complex fractionated atrial electrograms (CFAE)
Lin, Jiaxiong1; Scherlag, Benjamin J.1; Zhou, Jing1; Lu, Zhibing1; Patterson, Eugene1; Jackman, Warren M.1; Lazzara, Ralph1; Po, Sunny S.1
关键词Complex Fractionated Atrial Electrograms Atrial Fibrillation Autonomic Nervous System
刊名JOURNAL OF CARDIOVASCULAR ELECTROPHYSIOLOGY
2007-11-01
DOI10.1111/j.1540-8167.2007.00976.x
18期:11页:1197-1205
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Cardiac & Cardiovascular Systems
研究领域[WOS]Cardiovascular System & Cardiology
关键词[WOS]ISOLATED SHEEP HEART ; PULMONARY VEIN ; GANGLIONATED PLEXI ; NERVOUS-SYSTEM ; CATHETER ABLATION ; FIBRILLATION ; STIMULATION ; MODEL ; EXCITATION ; CONVERSION
英文摘要

Objective: To simulate complex fractionated atrial electrograms (CFAE) during sustained atrial fibrillation (AF) in experimental animals.

Background: The mechanism(s) underlying CFAE has not been fully elucidated.

Methods: Twenty-two dogs were subjected to a right and/or left thoracotomy. A gauze patch soaked with acetylcholine (ACh) was placed on the right atrial appendage (RAA) to induce sustained AF. During AF, varying concentrations of ACh (1, 10, 100 mM) were "painted" on the RA where electrograms showed regular organized activity. In another six dogs, anterior right ganglionated plexi (ARGP) near the sino-atrial node and inferior right GP (IRGP) at the junction of inferior vena cava and atria were sequentially ablated. In five dogs, ACh was injected into ARGP to induce CFAE.

Results: During sustained AF, local "painting" with ACh 1 mM and 10 mM induced intermittent CFAE in 1 of 11 and 10 of 11 dogs, respectively. With 100 mM ACh, all 11 showed CFAE (two intermittent, nine continuous). In six other dogs, continuous CFAE induced by topical application of 100 mM ACh were markedly attenuated by ARGP + IRGP ablation. In another five of five dogs, ACh injection into ARGP induced a gradient of CFAE with the continuous CFAE always occurring near the ARGP and CFAE also occurring at left pulmonary vein-atrial junctions. During ARGP ablation, AF was terminated in all five dogs immediately after regularization of the rotor-like electrograms or continuous CFAE.

Conclusions: This study demonstrates an autonomic basis for CFAE formation, suggesting that graded hyperactive states of the autonomic nervous system (ANS) may induce various types of CFAE observed clinically.

语种英语
WOS记录号WOS:000250264100013
引用统计
被引频次:105[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/52134
专题北京大学第一临床医学院_心血管内科
作者单位1.First Hosp Peking Univ, Dept Cardiol, Beijing, Peoples R China
2.Univ Oklahoma, Cardiac Arrhythmia Res Inst, Ctr Hlth Sci, Oklahoma City, OK 73104 USA
3.Fudan Univ, Zhongshan Hosp, Dept Cardiol, Shanghai 200433, Peoples R China
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Lin, Jiaxiong,Scherlag, Benjamin J.,Zhou, Jing,et al. Autonomic mechanism to explain complex fractionated atrial electrograms (CFAE)[J]. JOURNAL OF CARDIOVASCULAR ELECTROPHYSIOLOGY,2007,18(11):1197-1205.
APA Lin, Jiaxiong.,Scherlag, Benjamin J..,Zhou, Jing.,Lu, Zhibing.,Patterson, Eugene.,...&Po, Sunny S..(2007).Autonomic mechanism to explain complex fractionated atrial electrograms (CFAE).JOURNAL OF CARDIOVASCULAR ELECTROPHYSIOLOGY,18(11),1197-1205.
MLA Lin, Jiaxiong,et al."Autonomic mechanism to explain complex fractionated atrial electrograms (CFAE)".JOURNAL OF CARDIOVASCULAR ELECTROPHYSIOLOGY 18.11(2007):1197-1205.
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