IR@PKUHSC  > 北京大学第二临床医学院  > 心血管内科
学科主题临床医学
Analysis of Lipoprotein Subfractions in Chinese Han Patients with Stable Coronary Artery Disease
Xu, Rui-Xia1,2; Zhang, Yan1,2; Ye, Ping3; Chen, Hong4; Li, Yan-Fang5; Hua, Qi6; Guo, Yuan-Lin1,2; Li, Xiao-Lin1,2; Li, Sha1,2; Dong, Qian1,2; Liu, Geng1,2; Li, Jian-Jun1,2
关键词High-density Lipoprotein Subfraction Low-density Lipoprotein Subfraction Chinese Coronary Angiography Coronary Artery Disease
刊名HEART LUNG AND CIRCULATION
2015-12-01
DOI10.1016/j.hlc.2015.05.002
24期:12页:1203-1210
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Cardiac & Cardiovascular Systems
资助者National Natural Scientific Foundation ; Specialized Research Fund for the Doctoral Program of Higher Education of China ; Capital Special Foundation of Clinical Application Research ; Capital Health Development Fund ; Beijing Natural Science Foundation ; Specialized Research Personnel Fund of FuWai Hospital ; National Natural Scientific Foundation ; Specialized Research Fund for the Doctoral Program of Higher Education of China ; Capital Special Foundation of Clinical Application Research ; Capital Health Development Fund ; Beijing Natural Science Foundation ; Specialized Research Personnel Fund of FuWai Hospital
研究领域[WOS]Cardiovascular System & Cardiology
关键词[WOS]HDL PARTICLE FUNCTIONALITY ; SMALL DENSE LDL ; CARDIOVASCULAR-DISEASE ; MYOCARDIAL-INFARCTION ; COMBINATION THERAPY ; HEART-DISEASE ; CHOLESTEROL ; RISK ; ATHEROSCLEROSIS ; EVENTS
英文摘要

Background The relation of lipoprotein subfractions with stable coronary artery disease (CAD) has not been fully investigated in the Chinese Han population.

Methods Four-hundred-and-thirteen consecutive patients without any lipid-lowering drug treatment were investigated. Patients were classified into two groups according to the angiographic results: CAD group (n=293) and non-CAD group (n=120). The high-density lipoprotein (HDL) and low-density lipoprotein (LDL) subfractions were analysed using the Quantimetrix Lipoprint system.

Results The data showed that the large HDL-cholesterol (HDL-C) level, large HDL subfraction percentage, and mean LDL particle size were significantly lower, while the small HDL-C level and HDL subfraction percentage, intermediate and small LDL-cholesterol (LDL-C) levels, and LDL subfraction percentages were higher in the CAD group compared with those in the non-CAD group. Interestingly, our results suggested that the small HDL-C level and HDL subfraction percentage as well as mean LDL particle size were independently associated with the presence of CAD assessed by logistic regression analysis (OR=1.136, 95%CI=1.018-1.268, p=0.022; OR=1.076, 95%CI=1.021-1.134, p=0.007; OR=0.946, 95%CI=0.898-0.997, p=0.040; respectively).

Conclusions Similar to previous Western population studies, our data suggested a clear association between the lipoprotein subfractions and stable CAD presented as higher small HDL subfraction and smaller mean LDL particle size in Chinese Han patients.

语种英语
所属项目编号81070171 ; 81100118 ; 81241121 ; 20101106120007 ; 20111106110013 ; Z121107001012015 ; 2011400302 ; 7131014 ; 2012-FWXX02
资助者National Natural Scientific Foundation ; Specialized Research Fund for the Doctoral Program of Higher Education of China ; Capital Special Foundation of Clinical Application Research ; Capital Health Development Fund ; Beijing Natural Science Foundation ; Specialized Research Personnel Fund of FuWai Hospital ; National Natural Scientific Foundation ; Specialized Research Fund for the Doctoral Program of Higher Education of China ; Capital Special Foundation of Clinical Application Research ; Capital Health Development Fund ; Beijing Natural Science Foundation ; Specialized Research Personnel Fund of FuWai Hospital
WOS记录号WOS:000365351300016
Citation statistics
Cited Times:6[WOS]   [WOS Record]     [Related Records in WOS]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/52147
Collection北京大学第二临床医学院_心血管内科
作者单位1.Peking Union Med Coll, Beijing 100037, Peoples R China
2.Chinese Acad Med Sci, State Key Lab Cardiovasc Dis, Natl Ctr Cardiovasc Dis, Div Dyslipidemia,FuWai Hosp, Beijing 100037, Peoples R China
3.Chinese Peoples Liberat Army, Hosp 301, Dept Cardiol, Beijing 100853, Peoples R China
4.Peking Univ, Peoples Hosp, Dept Cardiol, Beijing 100044, Peoples R China
5.Capital Med Univ, Beijing Anzhen Hosp, Dept Cardiol, Beijing 100029, Peoples R China
6.Capital Med Univ, Xuanwu Hosp, Dept Neurol, Beijing 100053, Peoples R China
Recommended Citation
GB/T 7714
Xu, Rui-Xia,Zhang, Yan,Ye, Ping,et al. Analysis of Lipoprotein Subfractions in Chinese Han Patients with Stable Coronary Artery Disease[J]. HEART LUNG AND CIRCULATION,2015,24(12):1203-1210.
APA Xu, Rui-Xia.,Zhang, Yan.,Ye, Ping.,Chen, Hong.,Li, Yan-Fang.,...&Li, Jian-Jun.(2015).Analysis of Lipoprotein Subfractions in Chinese Han Patients with Stable Coronary Artery Disease.HEART LUNG AND CIRCULATION,24(12),1203-1210.
MLA Xu, Rui-Xia,et al."Analysis of Lipoprotein Subfractions in Chinese Han Patients with Stable Coronary Artery Disease".HEART LUNG AND CIRCULATION 24.12(2015):1203-1210.
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