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学科主题: 临床医学
题名:
Analysis of Lipoprotein Subfractions in Chinese Han Patients with Stable Coronary Artery Disease
作者: Xu, Rui-Xia1,2; Zhang, Yan1,2; Ye, Ping3; Chen, Hong4; Li, Yan-Fang5; Hua, Qi6; Guo, Yuan-Lin1,2; Li, Xiao-Lin1,2; Li, Sha1,2; Dong, Qian1,2; Liu, Geng1,2; Li, Jian-Jun1,2
关键词: High-density lipoprotein subfraction ; Low-density lipoprotein subfraction ; Chinese ; Coronary angiography ; Coronary artery disease
刊名: HEART LUNG AND CIRCULATION
发表日期: 2015-12-01
DOI: 10.1016/j.hlc.2015.05.002
卷: 24, 期:12, 页:1203-1210
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Cardiac & Cardiovascular Systems
研究领域[WOS]: Cardiovascular System & Cardiology
关键词[WOS]: HDL PARTICLE FUNCTIONALITY ; SMALL DENSE LDL ; CARDIOVASCULAR-DISEASE ; MYOCARDIAL-INFARCTION ; COMBINATION THERAPY ; HEART-DISEASE ; CHOLESTEROL ; RISK ; ATHEROSCLEROSIS ; EVENTS
英文摘要:

Background The relation of lipoprotein subfractions with stable coronary artery disease (CAD) has not been fully investigated in the Chinese Han population.

Methods Four-hundred-and-thirteen consecutive patients without any lipid-lowering drug treatment were investigated. Patients were classified into two groups according to the angiographic results: CAD group (n=293) and non-CAD group (n=120). The high-density lipoprotein (HDL) and low-density lipoprotein (LDL) subfractions were analysed using the Quantimetrix Lipoprint system.

Results The data showed that the large HDL-cholesterol (HDL-C) level, large HDL subfraction percentage, and mean LDL particle size were significantly lower, while the small HDL-C level and HDL subfraction percentage, intermediate and small LDL-cholesterol (LDL-C) levels, and LDL subfraction percentages were higher in the CAD group compared with those in the non-CAD group. Interestingly, our results suggested that the small HDL-C level and HDL subfraction percentage as well as mean LDL particle size were independently associated with the presence of CAD assessed by logistic regression analysis (OR=1.136, 95%CI=1.018-1.268, p=0.022; OR=1.076, 95%CI=1.021-1.134, p=0.007; OR=0.946, 95%CI=0.898-0.997, p=0.040; respectively).

Conclusions Similar to previous Western population studies, our data suggested a clear association between the lipoprotein subfractions and stable CAD presented as higher small HDL subfraction and smaller mean LDL particle size in Chinese Han patients.

语种: 英语
所属项目编号: 81070171 ; 81100118 ; 81241121 ; 20101106120007 ; 20111106110013 ; Z121107001012015 ; 2011400302 ; 7131014 ; 2012-FWXX02
项目资助者: National Natural Scientific Foundation ; Specialized Research Fund for the Doctoral Program of Higher Education of China ; Capital Special Foundation of Clinical Application Research ; Capital Health Development Fund ; Beijing Natural Science Foundation ; Specialized Research Personnel Fund of FuWai Hospital
WOS记录号: WOS:000365351300016
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/52147
Appears in Collections:北京大学第二临床医学院_心血管内科_期刊论文

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作者单位: 1.Peking Union Med Coll, Beijing 100037, Peoples R China
2.Chinese Acad Med Sci, State Key Lab Cardiovasc Dis, Natl Ctr Cardiovasc Dis, Div Dyslipidemia,FuWai Hosp, Beijing 100037, Peoples R China
3.Chinese Peoples Liberat Army, Hosp 301, Dept Cardiol, Beijing 100853, Peoples R China
4.Peking Univ, Peoples Hosp, Dept Cardiol, Beijing 100044, Peoples R China
5.Capital Med Univ, Beijing Anzhen Hosp, Dept Cardiol, Beijing 100029, Peoples R China
6.Capital Med Univ, Xuanwu Hosp, Dept Neurol, Beijing 100053, Peoples R China

Recommended Citation:
Xu, Rui-Xia,Zhang, Yan,Ye, Ping,et al. Analysis of Lipoprotein Subfractions in Chinese Han Patients with Stable Coronary Artery Disease[J]. HEART LUNG AND CIRCULATION,2015,24(12):1203-1210.
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