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学科主题: 精神卫生
题名:
Fisher discriminative analysis of resting-state brain function for attention-deficit/hyperactivity disorder
作者: Zhu, Chao-Zhe1,2; Zang, Yu-Feng1,2; Cao, Qing-Jiu3; Yan, Chao-Gan1; He, Yong4; Jiang, Tian-Zi2; Sui, Man-Qiu3; Wang, Yu-Feng3
关键词: Fisher discriminative analysis ; ADHD ; ReHo ; resting state ; fMRI
刊名: NEUROIMAGE
发表日期: 2008-03-01
DOI: 10.1016/j.neuroimage.2007.11.029
卷: 40, 期:1, 页:110-120
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Neurosciences ; Neuroimaging ; Radiology, Nuclear Medicine & Medical Imaging
研究领域[WOS]: Neurosciences & Neurology ; Radiology, Nuclear Medicine & Medical Imaging
关键词[WOS]: DEFICIT HYPERACTIVITY DISORDER ; ANTERIOR CINGULATE CORTEX ; REGIONAL HOMOGENEITY ; PERFORMANCE METRICS ; ACTIVATION PATTERNS ; ALZHEIMERS-DISEASE ; CONNECTIVITY ; MRI ; CLASSIFICATION ; CHILDREN
英文摘要:

In this study a resting-state fMRI based classifier, for the first time, was proposed and applied to discriminate children with attention-deficit/hyperactivity disorder (ADHD) from normal controls. On the basis of regional homogeneity (ReHo), a mapping of brain function at resting state, PCA-based Fisher discriminative analysis (PC-FDA) was trained to build a linear classifier. Permutation test was then conducted to identify the brain areas with the most significant contribution to the final discrimination. Experimental results showed a correct classification rate of 85% using a leave-one-out cross-validation. Moreover, some highly discriminative brain regions, like the prefrontal cortex and anterior cingulate cortex, well confirmed the previous findings on ADHD. Interestingly, some important but less reported regions such as the thalamus were also identified. We conclude that the classifier, using resting-state brain function as classification feature, has potential ability to improve current diagnosis and treatment evaluation of ADHD. (c) 2007 Published by Elsevier Inc.

语种: 英语
WOS记录号: WOS:000253362100012
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/52150
Appears in Collections:北京大学精神卫生研究所_期刊论文

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作者单位: 1.Peking Univ, Inst Mental Hlth, Beijing 100871, Peoples R China
2.Beijing Normal Univ, State Key Lab Cognit Neurosci & Learning, Beijing 100875, Peoples R China
3.Chinese Acad Sci, Inst Automat, Natl Lab Pattern Recognit, Beijing 100875, Peoples R China
4.McGill Univ, Montreal Neurol Inst, McConnell Brain Imaging, Montreal, PQ H3A 2B4, Canada

Recommended Citation:
Zhu, Chao-Zhe,Zang, Yu-Feng,Cao, Qing-Jiu,et al. Fisher discriminative analysis of resting-state brain function for attention-deficit/hyperactivity disorder[J]. NEUROIMAGE,2008,40(1):110-120.
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