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Fisher discriminative analysis of resting-state brain function for attention-deficit/hyperactivity disorder
Zhu, Chao-Zhe1,2; Zang, Yu-Feng1,2; Cao, Qing-Jiu3; Yan, Chao-Gan1; He, Yong4; Jiang, Tian-Zi2; Sui, Man-Qiu3; Wang, Yu-Feng3
关键词Fisher Discriminative Analysis Adhd Reho Resting State Fmri
刊名NEUROIMAGE
2008-03-01
DOI10.1016/j.neuroimage.2007.11.029
40期:1页:110-120
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Neurosciences ; Neuroimaging ; Radiology, Nuclear Medicine & Medical Imaging
研究领域[WOS]Neurosciences & Neurology ; Radiology, Nuclear Medicine & Medical Imaging
关键词[WOS]DEFICIT HYPERACTIVITY DISORDER ; ANTERIOR CINGULATE CORTEX ; REGIONAL HOMOGENEITY ; PERFORMANCE METRICS ; ACTIVATION PATTERNS ; ALZHEIMERS-DISEASE ; CONNECTIVITY ; MRI ; CLASSIFICATION ; CHILDREN
英文摘要

In this study a resting-state fMRI based classifier, for the first time, was proposed and applied to discriminate children with attention-deficit/hyperactivity disorder (ADHD) from normal controls. On the basis of regional homogeneity (ReHo), a mapping of brain function at resting state, PCA-based Fisher discriminative analysis (PC-FDA) was trained to build a linear classifier. Permutation test was then conducted to identify the brain areas with the most significant contribution to the final discrimination. Experimental results showed a correct classification rate of 85% using a leave-one-out cross-validation. Moreover, some highly discriminative brain regions, like the prefrontal cortex and anterior cingulate cortex, well confirmed the previous findings on ADHD. Interestingly, some important but less reported regions such as the thalamus were also identified. We conclude that the classifier, using resting-state brain function as classification feature, has potential ability to improve current diagnosis and treatment evaluation of ADHD. (c) 2007 Published by Elsevier Inc.

语种英语
WOS记录号WOS:000253362100012
引用统计
被引频次:145[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/52150
专题北京大学精神卫生研究所
作者单位1.Peking Univ, Inst Mental Hlth, Beijing 100871, Peoples R China
2.Beijing Normal Univ, State Key Lab Cognit Neurosci & Learning, Beijing 100875, Peoples R China
3.Chinese Acad Sci, Inst Automat, Natl Lab Pattern Recognit, Beijing 100875, Peoples R China
4.McGill Univ, Montreal Neurol Inst, McConnell Brain Imaging, Montreal, PQ H3A 2B4, Canada
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GB/T 7714
Zhu, Chao-Zhe,Zang, Yu-Feng,Cao, Qing-Jiu,et al. Fisher discriminative analysis of resting-state brain function for attention-deficit/hyperactivity disorder[J]. NEUROIMAGE,2008,40(1):110-120.
APA Zhu, Chao-Zhe.,Zang, Yu-Feng.,Cao, Qing-Jiu.,Yan, Chao-Gan.,He, Yong.,...&Wang, Yu-Feng.(2008).Fisher discriminative analysis of resting-state brain function for attention-deficit/hyperactivity disorder.NEUROIMAGE,40(1),110-120.
MLA Zhu, Chao-Zhe,et al."Fisher discriminative analysis of resting-state brain function for attention-deficit/hyperactivity disorder".NEUROIMAGE 40.1(2008):110-120.
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