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学科主题基础医学
Role of prostaglandin E-2 and its receptors in the process of ductus arteriosus maturation and functional closure in the rabbit
Fan, Fen-Ling3,4; Zhu, Sen1; Chen, Li-Hong1; Zou, Yu-Liang2; Fan, Li-Hong3,4; Kang, Ji-Hong1; Ma, Ai-Qun3,4; Guan, You-Fei1
关键词Fetal Ductus Arteriosus Oxygen Tension Preterm Birth Prostaglandin E-2 Prostanoid Receptors
刊名CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY
2010-05-01
DOI10.1111/j.1440-1681.2010.05354.x
37期:5-6页:574-580
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Pharmacology & Pharmacy ; Physiology
研究领域[WOS]Pharmacology & Pharmacy ; Physiology
关键词[WOS]PROSTANOID RECEPTORS ; PRETERM INFANTS ; FETAL ; INDOMETHACIN ; MANAGEMENT ; EXPRESSION ; NEWBORN ; DEATH ; MICE
英文摘要

P>1. Patent ductus arteriosus (PDA) is a common congenital heart defect in premature infants. The present study was designed to determine the role of the prostaglandin (PG) E-2 pathway in the process of ductus arteriosus (DA) maturation and functional closure.

2. Changes in PGE(2) pathway-related enzymes and receptors in DA in preterm and term rabbits were examined at both the mRNA and protein levels. In addition, responses of DA rings to Po-2 and PGE(2) were determined.

3. Circulating PGE(2) levels remained high until 2 h after birth. High levels of the EP4 receptor were found in preterm DA. These tissues were sensitive to PGE(2), which caused vessel dilation, but were insensitive to increased Po-2. In contrast, DA tissues from term rabbits exhibited an immediate contractile response to increased Po-2 and PGE(2) treatment resulted in vasoconstriction, which was associated with increased EP3 and decreased EP4 receptor expression in term DA.

4. In conclusion, the preterm PDA is maintained by high levels of PGE(2), which mainly binds to the EP4 receptor under conditions of hypoxia. In contrast, in the term DA, in which levels of the EP3 receptor are higher than in preterm DA, exposure to PGE(2) resulted in vasoconstriction under normoxic conditions. These findings suggest that blocking the EP4 receptor may represent a more selective treatment for the preterm PDA, whereas activating the EP3 receptor may be more suitable for the treatment of the term PDA.

语种英语
WOS记录号WOS:000276776700009
项目编号30725033 ; 30530340 ; 2010CB912503
资助机构National Natural Science Foundation of China ; National Basic Research Program of China
引用统计
被引频次:3[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/52151
专题北京大学基础医学院_北京大学糖尿病中心
北京大学基础医学院
北京大学第二临床医学院_风湿免疫科
作者单位1.Peking Univ, Hlth Sci Ctr, Dept Physiol & Pathophysiol, Ctr Diabet, Beijing 100191, Peoples R China
2.Xi An Jiao Tong Univ, Affiliated Hosp 1, Dept Gynecol & Obstet, Xian 710049, Peoples R China
3.Xi An Jiao Tong Univ, Ctr Cardiovasc Med, Dept Cardiovasc Med, Key Lab Environm & Gene Related Dis,Minist Educ, Xian 710049, Peoples R China
4.Xi An Jiao Tong Univ, Ctr Cardiovasc Med, Res Lab Ion Channelopathy, Key Lab Environm & Gene Related Dis,Minist Educ, Xian 710049, Peoples R China
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GB/T 7714
Fan, Fen-Ling,Zhu, Sen,Chen, Li-Hong,et al. Role of prostaglandin E-2 and its receptors in the process of ductus arteriosus maturation and functional closure in the rabbit[J]. CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY,2010,37(5-6):574-580.
APA Fan, Fen-Ling.,Zhu, Sen.,Chen, Li-Hong.,Zou, Yu-Liang.,Fan, Li-Hong.,...&Guan, You-Fei.(2010).Role of prostaglandin E-2 and its receptors in the process of ductus arteriosus maturation and functional closure in the rabbit.CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY,37(5-6),574-580.
MLA Fan, Fen-Ling,et al."Role of prostaglandin E-2 and its receptors in the process of ductus arteriosus maturation and functional closure in the rabbit".CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY 37.5-6(2010):574-580.
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