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学科主题: 药学
题名:
Magnetic targeting after femoral artery administration and biocompatibility assessment of superparamagnetic iron oxide nanoparticles
作者: Ma, Hui-Li1; Qi, Xian-Rong1; Ding, Wu-Xiao1; Maitani, Yoshie2; Nagai, Tsuneji2
关键词: superparamagnetic iron oxide nanoparticles (SPION) ; magnetic targeting ; biocompatibility ; alginate ; localization ratio
刊名: JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A
发表日期: 2008-03-01
DOI: 10.1002/jbm.a.31346
卷: 84A, 期:3, 页:598-606
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Engineering, Biomedical ; Materials Science, Biomaterials
研究领域[WOS]: Engineering ; Materials Science
关键词[WOS]: COLORIMETRIC ASSAY ; IN-VIVO ; DELIVERY ; CARRIERS ; SYSTEM ; CANCER ; MICROSPHERES ; CHEMOTHERAPY ; DOXORUBICIN ; ADSORPTION
英文摘要:

Ferrofluids are attractive candidates for magnetic targeting system because of their fluidity and magnetism. The magnetic nanoparticles in ferrofluids should have combined properties of superparamagnetic behavior, target localization, and biocompatibility. The magnetic targeting and biocompatibility of superparamagnetic iron oxide nanoparticles stabilized by alginate (SPION-alginate) was investigated in vitro and in vivo. The localization of SPION-alginate by an external magnetic field in vitro was quantitatively evaluated by determining the iron content, and the results revealed that the localization ratio of SPION-alginate was 56%. Magnetic targeting of the SPION-alginate after femoral artery administration with the magnetic field in rats was quantitatively investigated by iron content and qualitatively confirmed by histological evaluation and magnetic resonance imaging. The ratio of iron content between the target site and the nontarget site were 8.88 at 0.5 h and 7.50 at 2 h, respectively. The viability of RAW264.7 cells and L929 cells was apparently unaltered upon exposure to SPION-alginate. The incubation with erythrocytes indicated that the SPION-alginate did not induce erythrocytes hemolysis and aggregation. In conclusions, the SPION-alginate had magnetic targeting with an external magnetic field and did not be detained at the injection site without the magnetic field. The SPION-alginate was generally considered to be biocompatible in cytotoxicity and hemolysis aspects. (C) 2007 Wiley Periodicals, Inc. J Biomed Mater Res.

语种: 英语
WOS记录号: WOS:000252990200004
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/52153
Appears in Collections:北京大学药学院_药剂学系_期刊论文

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作者单位: 1.Hoshi Univ, Inst Med Chem, Shinagawa Ku, Tokyo 142850, Japan
2.Peking Univ, Sch Pharmaceut Sci, Dept Pharmaceut, Beijing 100083, Peoples R China

Recommended Citation:
Ma, Hui-Li,Qi, Xian-Rong,Ding, Wu-Xiao,et al. Magnetic targeting after femoral artery administration and biocompatibility assessment of superparamagnetic iron oxide nanoparticles[J]. JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A,2008,84A(3):598-606.
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