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学科主题: 基础医学
题名:
CMTM1_v17 is a novel potential therapeutic target in breast cancer
作者: Wang, Jing1,2; Zhang, Guoying1,3; Zhang, Yingmei1,3; Luo, Yang1,3; Song, Quansheng1,3; Qiu, Xiaoyan1,3; Mo, Xiaoning1,3; Wang, Lu1,3
关键词: CMTM1_v17 ; therapeutic target ; breast cancer ; tumor necrosis factor-alpha ; apoptosis
刊名: ONCOLOGY REPORTS
发表日期: 2014-11-01
DOI: 10.3892/or.2014.3429
卷: 32, 期:5, 页:1829-1836
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Oncology
研究领域[WOS]: Oncology
关键词[WOS]: CHEMOKINE-LIKE FACTOR ; MOLECULAR-CLONING ; CELL GROWTH ; GENE ; IDENTIFICATION ; METHYLATION ; EXPRESSION ; ISOFORMS ; TESTIS
英文摘要:

Chemokine-like factor (CKLF)-like MARVEL transmembrane domain-containing 1 (CMTM1) consists of at least 23 alternatively spliced isoforms designated CMTM1_v1-v23. In the present study, we detected CMTM1_v17 expression in multiple human normal and tumor tissues and found that CMTM1_v17 was highly expressed in testis and many tumor tissues including breast tumor. The overexpression of CMTM1_v17 in the breast cancer cell line MDA-MB-231 promoted cell proliferation and resistance to tumor necrosis factor-alpha (TNF-alpha)-induced apoptosis. Moreover, siRNA-mediated silencing of CMTM1_v17 sensitized MDA-MB-231 cells to TNF-alpha-induced apoptosis. We propose that CMTM1_v17 may be a novel potential target for therapy in breast cancer patients. The present study provides insight into a novel mechanism by which CMTM1_v17 enhances cellular proliferation and abrogates TNF-alpha-induced apoptosis. These findings also have implications for clinical practice as they highlight the potential for therapeutic targeting of CMTM1_v17 for the treatment of breast and other cancers in which CMTM1_v17 impacts cellular proliferation and survival.

语种: 英语
所属项目编号: 91129707 ; 81172001
项目资助者: National Natural Science Foundation of China
WOS记录号: WOS:000342714000010
Citation statistics:
内容类型: 期刊论文
版本: 出版稿
URI标识: http://ir.bjmu.edu.cn/handle/400002259/52154
Appears in Collections:基础医学院_免疫学系_期刊论文

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作者单位: 1.Peking Univ, Sch Basic Med Sci, Dept Immunol, Ctr Human Dis Genom, Beijing 100191, Peoples R China
2.Capital Med Univ, Beijing Shijitan Hosp, Dept Clin Lab, Beijing 100038, Peoples R China
3.Peking Univ, Sch Basic Med Sci, Key Lab Med Immunol, Minist Hlth, Beijing 100191, Peoples R China

Recommended Citation:
Wang, Jing,Zhang, Guoying,Zhang, Yingmei,et al. CMTM1_v17 is a novel potential therapeutic target in breast cancer[J]. ONCOLOGY REPORTS,2014,32(5):1829-1836.
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