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学科主题: 药学
题名:
Preparation of tri-block copolymer micelles loading novel organoselenium anticancer drug BBSKE and study of tissue distribution of copolymer micelles by imaging in vivo method
作者: Liu, Mi1,2; Fu, Jianing1,2; Li, Jing1,2; Wang, Lihui1,2; Tan, Qiang1,2; Ren, Xiaoyuan1,2; Peng, Zuofu3; Zeng, Huihui1,2
关键词: Polymeric micelles ; Imaging in vivo ; Anticancer ; MCF-7 ; BBSKE
刊名: INTERNATIONAL JOURNAL OF PHARMACEUTICS
发表日期: 2010-05-31
DOI: 10.1016/j.ijpharm.2010.03.001
卷: 391, 期:1-2, 页:292-304
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Pharmacology & Pharmacy
研究领域[WOS]: Pharmacology & Pharmacy
关键词[WOS]: FOLATE RECEPTOR ; CELL-LINES ; DOXORUBICIN ; DELIVERY ; LIPOSOMES ; ADRIAMYCIN ; INHIBITOR ; THIOREDOXIN ; FORMULATION ; RESISTANCE
英文摘要:

BBSKE (1,2-[bis(1,2-benzisoselenazolone-3(2H)-ketone)] ethane, PCT: CN02/00412) is a novel organoselenium anticancer drug that plays a role in anticancer through inhibiting TrxR (thioredoxin reductase). In this study, we prepared a tri-block copolymer micelles loading BBSKE utilizing the amphiphilic triblock copolymers (PEG6000-PLA6000) which we synthesized. And then the characters of the copolymer micelles were investigated. When packaged in polymeric micelles, the water solubility of BBSKE was improved to 0.21 mg/ml. The IC(50) were 7.14 mu M, 5.05 mu M and 4.23 mu M when MCF-7 breast cancer cells were treated with BBSKE after 24 h, 48 h and 72 h. The inhibition effect of polymeric micelles to MCF-7 tumor cells was bettered when folate, whose receptor was highly expressed in various tumors, was coated on the surface of these nanoparticles. Finally, by adopting a new way of imaging in vivo, we studied the distribution of micelles in nude mice with and without MCF-7 tumor. The results demonstrated that this copolymer micelles loading BBSKE can accumulate into tumor efficiently. (C) 2010 Elsevier B.V. All rights reserved.

语种: 英语
WOS记录号: WOS:000278342900036
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/52157
Appears in Collections:北京大学药学院_期刊论文

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作者单位: 1.State Key Lab Nat & Biomimet Drugs, Beijing 100191, Peoples R China
2.Chilong Hlth Care Int Ltd Corp, Chilong, Peoples R China
3.Peking Univ, Sch Pharmaceut Sci, Beijing 100191, Peoples R China

Recommended Citation:
Liu, Mi,Fu, Jianing,Li, Jing,et al. Preparation of tri-block copolymer micelles loading novel organoselenium anticancer drug BBSKE and study of tissue distribution of copolymer micelles by imaging in vivo method[J]. INTERNATIONAL JOURNAL OF PHARMACEUTICS,2010,391(1-2):292-304.
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