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学科主题: 基础医学
题名:
The metabolic evidence of synergistic effect between ohmefentanyl and [D-Pen(2), D-Pen(5)] enkephalin on differentiated SH-SY5Y cells in humans
作者: Chen, ZW; Yang, K; Wang, Y; Han, JS
关键词: ohmefentanyl ; [D-Pen(2) ; D-Pen(5)] enkephalin ; synergy ; microphysiometer ; extracellular acidification rate ; SH-SY5Y cells
刊名: NEUROSCIENCE LETTERS
发表日期: 2001-02-09
卷: 298, 期:3, 页:199-202
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Neurosciences
研究领域[WOS]: Neurosciences & Neurology
关键词[WOS]: OPIOID RECEPTORS ; SPINAL-CORD ; BIOLOGICAL APPLICATIONS ; MU ; MOUSE ; MICROPHYSIOMETER ; ANTINOCICEPTION ; ACTIVATION ; AGONISTS ; RELEASE
英文摘要:

Interactions between selective opioid agonists acting at mu- and delta -opioid receptors were evaluated by co-administering a low-effective dose of the selective mu -opioid receptor agonist ohmefentanyl (OMF) with sequentially increasing doses of the selective delta -opioid receptor agonist [D-Pen(2), D-Pen(5)] enkephalin (DPDPE). Microphysiometer was used to measure the extracellular acidification rate (ECAR) of living cells in real-time, which reflected the functional activity after agonist-receptor binding. The synergy (i.e. a more than additive effect) was observed with combinations of these two opioid agonists on differentiated SH-SY5Y cells functionally expressing both mu- and delta -opioid receptors, The demonstration of the synergy suggests that the agonists of the subtypes of opioid receptors can interact at cellular level. (C) 2001 Elsevier Science Ireland Ltd. All rights reserved.

语种: 英语
WOS记录号: WOS:000166787700014
Citation statistics:
内容类型: 期刊论文
版本: 出版稿
URI标识: http://ir.bjmu.edu.cn/handle/400002259/52163
Appears in Collections:基础医学院_神经生物学系_期刊论文

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作者单位: Peking Univ, Neurosci Res Inst, Ctr Hlth, Beijing 100083, Peoples R China

Recommended Citation:
Chen, ZW,Yang, K,Wang, Y,et al. The metabolic evidence of synergistic effect between ohmefentanyl and [D-Pen(2), D-Pen(5)] enkephalin on differentiated SH-SY5Y cells in humans[J]. NEUROSCIENCE LETTERS,2001,298(3):199-202.
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