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学科主题基础医学
The metabolic evidence of synergistic effect between ohmefentanyl and [D-Pen(2), D-Pen(5)] enkephalin on differentiated SH-SY5Y cells in humans
Chen, ZW; Yang, K; Wang, Y; Han, JS
关键词ohmefentanyl [D-Pen(2) D-Pen(5)] enkephalin synergy microphysiometer extracellular acidification rate SH-SY5Y cells
刊名NEUROSCIENCE LETTERS
2001-02-09
298期:3页:199-202
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Neurosciences
研究领域[WOS]Neurosciences & Neurology
关键词[WOS]OPIOID RECEPTORS ; SPINAL-CORD ; BIOLOGICAL APPLICATIONS ; MU ; MOUSE ; MICROPHYSIOMETER ; ANTINOCICEPTION ; ACTIVATION ; AGONISTS ; RELEASE
英文摘要

Interactions between selective opioid agonists acting at mu- and delta -opioid receptors were evaluated by co-administering a low-effective dose of the selective mu -opioid receptor agonist ohmefentanyl (OMF) with sequentially increasing doses of the selective delta -opioid receptor agonist [D-Pen(2), D-Pen(5)] enkephalin (DPDPE). Microphysiometer was used to measure the extracellular acidification rate (ECAR) of living cells in real-time, which reflected the functional activity after agonist-receptor binding. The synergy (i.e. a more than additive effect) was observed with combinations of these two opioid agonists on differentiated SH-SY5Y cells functionally expressing both mu- and delta -opioid receptors, The demonstration of the synergy suggests that the agonists of the subtypes of opioid receptors can interact at cellular level. (C) 2001 Elsevier Science Ireland Ltd. All rights reserved.

语种英语
WOS记录号WOS:000166787700014
引用统计
文献类型期刊论文
版本出版稿
条目标识符http://ir.bjmu.edu.cn/handle/400002259/52163
专题北京大学基础医学院_神经生物学系
北京大学基础医学院
北京大学第二临床医学院_医疗美容科
作者单位Peking Univ, Neurosci Res Inst, Ctr Hlth, Beijing 100083, Peoples R China
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Chen, ZW,Yang, K,Wang, Y,et al. The metabolic evidence of synergistic effect between ohmefentanyl and [D-Pen(2), D-Pen(5)] enkephalin on differentiated SH-SY5Y cells in humans[J]. NEUROSCIENCE LETTERS,2001,298(3):199-202.
APA Chen, ZW,Yang, K,Wang, Y,&Han, JS.(2001).The metabolic evidence of synergistic effect between ohmefentanyl and [D-Pen(2), D-Pen(5)] enkephalin on differentiated SH-SY5Y cells in humans.NEUROSCIENCE LETTERS,298(3),199-202.
MLA Chen, ZW,et al."The metabolic evidence of synergistic effect between ohmefentanyl and [D-Pen(2), D-Pen(5)] enkephalin on differentiated SH-SY5Y cells in humans".NEUROSCIENCE LETTERS 298.3(2001):199-202.
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