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学科主题: 临床医学
题名:
Differential Proteomic Profiling of Chordomas and Analysis of Prognostic Factors
作者: Zhou, Hua1; Chen, Chang-Bao1; Lan, Jie1; Liu, Chao2; Liu, Xiao-Guang1; Jiang, Liang1; Wei, Feng1; Ma, Qing-Jun1; Dang, Geng-Ting1; Liu, Zhong-Jun1
关键词: chordoma ; proteomics ; prognosis ; cervical spine ; spinal tumor
刊名: JOURNAL OF SURGICAL ONCOLOGY
发表日期: 2010-12-01
DOI: 10.1002/jso.21674
卷: 102, 期:7, 页:720-727
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Oncology ; Surgery
研究领域[WOS]: Oncology ; Surgery
关键词[WOS]: EN-BLOC RESECTION ; CARBON ION RADIOTHERAPY ; SPINAL COLUMN TUMORS ; SACRAL CHORDOMA ; CERVICAL-SPINE ; MOBILE SPINE ; SURGICAL TECHNIQUE ; VERTEBRAL TUMORS ; TOTAL SACRECTOMY ; NATURAL-HISTORY
英文摘要:

Background: The recurrence rate of chordoma is high, and the prognosis is poor.

Methods: Differential proteomic analysis was performed on chordomas and adjacent normal tissues, with verification by Western blot. Protein expression was evaluated by immunohistochemistry of 37 chordomas. Association of candidate protein expression with clinical parameters, disease-free survival, and overall survival were analyzed.

Results: We identified 14 up-regulated and 5 down-regulated proteins in chordomas. Expression of alpha enolase (ENO1), pyruvate kinase M2 (PKM2), and gp96 was higher in recurrences than in primary tumors. Univariate analysis showed that significantly adverse factors for disease-free survival were overexpression of ENO1 and PKM2, involvement of contiguous vertebral levels, and inadequate surgical margin at initial surgery. Inadequate surgical margin without radiotherapy, involvement of contiguous vertebral levels, and cervical spine location were adverse factors for overall survival. By multivariate analysis, independent adverse prognostic factors were inadequate surgical margin and involvement of multiple contiguous vertebral levels for recurrence; upper cervical spine location and involvement of contiguous vertebral levels for tumor-related death. Multivariate analysis failed to show the significance of the proteins.

Conclusions: Involvements of multiple contiguous vertebral levels and upper cervical spine, rather than overexpression of ENO1. PKM2, or gp96, are independent prognostic indicators for chordomas. J. Surg. Oncol. 2010:102:720-727. (C) 2010 Wiley-Liss, Inc.

语种: 英语
所属项目编号: IRT0703 ; WSB08-6-15
项目资助者: Program for Changjiang Scholars and Innovative Research Team in University ; Ministry of Health
WOS记录号: WOS:000285281300004
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/52164
Appears in Collections:北京大学第三临床医学院_骨科_期刊论文

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作者单位: 1.Peking Univ, Dept Orthoped, Hosp 3, Beijing 100191, Peoples R China
2.Beihang Univ, LMIB, Minist Educ, Sch Math & Syst Sci, Beijing, Peoples R China

Recommended Citation:
Zhou, Hua,Chen, Chang-Bao,Lan, Jie,et al. Differential Proteomic Profiling of Chordomas and Analysis of Prognostic Factors[J]. JOURNAL OF SURGICAL ONCOLOGY,2010,102(7):720-727.
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