|Temporal trends of main reproductive characteristics in ten urban and rural regions of China: the China Kadoorie Biobank study of 300 000 women|
|Lewington, Sarah1,2; Li, LiMing3,4; Murugasen, Serini1,2; Hong, Lai-san1,2; Yang, Ling1,2; Guo, Yu4; Bian, Zheng4; Collins, Rory1,2; Chen, Junshi5; He, Hui6; Wu, Ming7; He, Tianyou8; Ren, Xiaolan9; Meng, Jinhuai10; Peto, Richard1,2; Chen, Zhengming1,2; China Kadoorie Biobank Study1|
|关键词||Reproductive Temporal Trends China Cohort Study|
|刊名||INTERNATIONAL JOURNAL OF EPIDEMIOLOGY|
|收录类别||SCI ; SSCI|
|WOS标题词||Science & Technology|
|类目[WOS]||Public, Environmental & Occupational Health|
|研究领域[WOS]||Public, Environmental & Occupational Health|
|关键词[WOS]||1944-1945 DUTCH FAMINE ; TERM-FOLLOW-UP ; BREAST-CANCER ; RISK-FACTORS ; AGE ; MENARCHE ; MENOPAUSE ; POPULATION ; FERTILITY ; EXPOSURE|
Background: Chinese women′s reproductive patterns have changed significantly over the past several decades. However, relatively little is known about the pace and characteristics of these changes either overall or by region and socioeconomic status.
Methods: We examined the cross-sectional data from the China Kadoorie Biobank cohort study that recruited 300 000 women born between 1930 and 1974 (mean age: 51 years) from 10 socially diverse urban and rural regions of China. Temporal trends in several self-reported reproductive characteristics, and effect modification of these trends by area and education (as a surrogate for socioeconomic status), were examined.
Results: The overall mean age at menarche was 15.4 (standard deviation 1.9) years, but decreased steadily over the 45 birth cohorts from 16.1 to 14.3 years, except for an anomalous increase of similar to 1 year for women exposed to the 1958-61 famine in early adolescence. Similarly large changes were seen for other characteristics: mean parity fell (urban: 4.9 to 1.1; rural: 5.9 to 1.4); mean age at first birth increased (urban: 19.0 to 25.9 years; rural: 18.3 to 23.8 years); and birth spacing increased after 1980 to over 5 years. Breastfeeding declined after 1950 in urban and, after 1980, in rural women; and 68% of urban and 48% of rural women experienced a terminated pregnancy. Mean age at menopause increased from 47.9 to 49.3 years.
Conclusions There have been striking changes in reproductive factors over time and between areas among these Chinese women. Their effects on major chronic diseases should be investigated.
|项目编号||088158/Z/09/Z ; 2011BAI09B01|
|资助机构||Kadoorie Charitable Foundation in Hong Kong ; Wellcome Trust in the UK ; Chinese Ministry of Science and Technology ; UK Medical Research Council ; British Heart Foundation (BHF) ; Cancer Research UK|
|作者单位||1.Univ Oxford, Clin Trial Serv Unit, Oxford OX3 7LF, England|
2.Univ Oxford, Epidemiol Studies Unit, Oxford OX3 7LF, England
3.Chinese Natl Ctr Food Safety Risk Assessment, Beijing, Peoples R China
4.Nangang Ctr Dis Control, Haerbin, Heilongjiang, Peoples R China
5.Jiangsu Ctr Dis Control, Nanjing, Jiangsu, Peoples R China
6.Huixian Ctr Dis Control, Huixian, Hennan, Peoples R China
7.Gansu Ctr Dis Control, Lanzhou, Gansu, Peoples R China
8.Liuzhou Ctr Dis Control, Liuzhou, Guangxi, Peoples R China
9.Peking Univ, Hlth Sci Ctr, Sch Publ Hlth, Beijing 100871, Peoples R China
10.Chinese Acad Med Sci, Beijing 100730, Peoples R China
|Lewington, Sarah,Li, LiMing,Murugasen, Serini,et al. Temporal trends of main reproductive characteristics in ten urban and rural regions of China: the China Kadoorie Biobank study of 300 000 women[J]. INTERNATIONAL JOURNAL OF EPIDEMIOLOGY,2014,43(4):1252-1262.|
|APA||Lewington, Sarah.,Li, LiMing.,Murugasen, Serini.,Hong, Lai-san.,Yang, Ling.,...&China Kadoorie Biobank Study.(2014).Temporal trends of main reproductive characteristics in ten urban and rural regions of China: the China Kadoorie Biobank study of 300 000 women.INTERNATIONAL JOURNAL OF EPIDEMIOLOGY,43(4),1252-1262.|
|MLA||Lewington, Sarah,et al."Temporal trends of main reproductive characteristics in ten urban and rural regions of China: the China Kadoorie Biobank study of 300 000 women".INTERNATIONAL JOURNAL OF EPIDEMIOLOGY 43.4(2014):1252-1262.|