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学科主题临床医学
Metabolism alteration in follicular niche: The nexus among intermediary metabolism, mitochondrial function, and classic polycystic ovary syndrome
Zhao, Hongcui1,2,3; Zhao, Yue1,2,3; Li, Tianjie1; Li, Min1,2,3; Li, Junsheng1,2,3; Li, Rong1,2,3; Liu, Ping1,2,3; Yu, Yang1,2,3; Qiao, Jie1,2,3
关键词Polycystic Ovary Syndrome Metabolism Follicle Fluid Cumulus Cells Pregnant Outcome
刊名FREE RADICAL BIOLOGY AND MEDICINE
2015-09-01
DOI10.1016/j.freeradbiomed.2015.05.013
86页:295-307
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Biochemistry & Molecular Biology ; Endocrinology & Metabolism
资助者National Natural Science Funds ; Ministry of Science and Technology of China Grants (973 program) ; Beijing Nova Program ; Specialized Research Fund for the Doctoral Program of Higher Education ; National Natural Science Funds ; Ministry of Science and Technology of China Grants (973 program) ; Beijing Nova Program ; Specialized Research Fund for the Doctoral Program of Higher Education
研究领域[WOS]Biochemistry & Molecular Biology ; Endocrinology & Metabolism
关键词[WOS]PERFORMANCE LIQUID-CHROMATOGRAPHY ; INSULIN-RESISTANCE ; OXIDATIVE STRESS ; MASS-SPECTROMETRY ; SKELETAL-MUSCLE ; INHIBITION ; OOCYTES ; PLASMA ; METABOLOMICS ; EXPRESSION
英文摘要

Classic polycystic ovary syndrome (PCOS) is a high-risk phenotype accompanied by increased risks of reproductive and metabolic abnormalities; however, the local metabolism characteristics of the ovaries and their effects on germ cell development are unclear. The present study used targeted metabolomics to detect alterations in the intermediate metabolites of follicular fluid from classic PCOS patients, and the results indicated that hyperandrogenism but not obesity induced the changed intermediate metabolites in classic PCOS patients. Regarding the direct contact, we identified mitochondrial function, redox potential, and oxidative stress in cumulus cells which were necessary to support oocyte growth before fertilization, and suggested dysfunction of mitochondria, imbalanced redox potential, and increased oxidative stress in cumulus cells of classic PCOS patients. Follicular fluid intermediary metabolic profiles provide signatures of classic PCOS ovary local metabolism and establish a close link with mitochondria dysfunction of cumulus cells, highlighting the role of metabolic signal and mitochondrial cross talk involved in the pathogenesis of classic PCOS. (C) 2015 Flsevier Inc. All rights reserved.

语种英语
所属项目编号31230047 ; 31371521 ; 81170538 ; 81471427 ; 2014CB943203 ; xxjh2015011 ; 20120001130008
资助者National Natural Science Funds ; Ministry of Science and Technology of China Grants (973 program) ; Beijing Nova Program ; Specialized Research Fund for the Doctoral Program of Higher Education ; National Natural Science Funds ; Ministry of Science and Technology of China Grants (973 program) ; Beijing Nova Program ; Specialized Research Fund for the Doctoral Program of Higher Education
WOS记录号WOS:000360569700028
引用统计
被引频次:5[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/52168
专题北京大学第三临床医学院_生殖医学中心
作者单位1.Minist Educ, Key Lab Assisted Reprod, Beijing 100191, Peoples R China
2.Peking Univ, Hosp 3, Dept Obstet & Gynecol, Ctr Reprod Med, Beijing 100191, Peoples R China
3.Beijing Key Lab Reprod Endocrinol & Assisted Repr, Beijing 100191, Peoples R China
推荐引用方式
GB/T 7714
Zhao, Hongcui,Zhao, Yue,Li, Tianjie,et al. Metabolism alteration in follicular niche: The nexus among intermediary metabolism, mitochondrial function, and classic polycystic ovary syndrome[J]. FREE RADICAL BIOLOGY AND MEDICINE,2015,86:295-307.
APA Zhao, Hongcui.,Zhao, Yue.,Li, Tianjie.,Li, Min.,Li, Junsheng.,...&Qiao, Jie.(2015).Metabolism alteration in follicular niche: The nexus among intermediary metabolism, mitochondrial function, and classic polycystic ovary syndrome.FREE RADICAL BIOLOGY AND MEDICINE,86,295-307.
MLA Zhao, Hongcui,et al."Metabolism alteration in follicular niche: The nexus among intermediary metabolism, mitochondrial function, and classic polycystic ovary syndrome".FREE RADICAL BIOLOGY AND MEDICINE 86(2015):295-307.
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