IR@PKUHSC  > 北京大学药学院  > 药剂学系
学科主题药学
Hepatocyte-Targeted Delivery Using pH-Sensitive Liposomes Loaded with Lactosylnorcantharidin Phospholipid Complex: Preparation, Characterization, and Therapeutic Evaluation In Vivo and In Vitro
Qiao-ling, Z.1; Yi, Z.1; Min, G.1; Di-jia, Y.1,2; Xiao-feng, Z.1,3; Yang, L.1; Jing-yu, X.1; Ying, W.1; Zong-lin, G.1; Kong-lang, X.1; Ai-jun, Z.1; Wei-liang, C.1; Lin-sen, S.1; Xue-nong, Z.1; Qiang, Z.4
关键词Hepatocyte-targeted Delivery Lactosyl-norcantharidin Lipsomes Ph Sensitive Phospholipid Complex Hepg2 Cells Release Cytotoxicity Cellular Uptake Near-infrared Fluoressence
刊名CURRENT MEDICINAL CHEMISTRY
2012-11-01
19期:33页:5754-5763
收录类别SCI
文章类型Review
WOS标题词Science & Technology
类目[WOS]Biochemistry & Molecular Biology ; Chemistry, Medicinal ; Pharmacology & Pharmacy
研究领域[WOS]Biochemistry & Molecular Biology ; Pharmacology & Pharmacy
关键词[WOS]DRUG-DELIVERY ; CANCER-THERAPY ; NANOPARTICLES ; NORCANTHARIDIN ; SIZE ; DIAGNOSIS ; RELEASE ; SYSTEMS
英文摘要

Liposomes loaded with lactosyl-norcantharidin phospholipid complex (LPC) were prepared, in which soybean phosphatidylcholine was used to improve the liposolubility of lactosyl-norcantharidin (Lac-NCTD). The pH-sensitive LPC liposomes (pH-LPC-lips) were obtained by electrostatic adsorption of the carboxymethyl chitosan onto the surface of the liposomes. The in vitro drug release of pH-LPC-lips and LPC-lips was investigated in dissolution media with pH ranging from 1.0 to 8.0. The in vitro antitumor activity and cellular uptake of Lac-NCTD and its liposomes to HepG2 cells were studied. The pH-LPC-lips demonstrated strong cytotoxicity against the cells and easily permeated the cell membrane. The in vivo antitumor activities of Lac-NCTD and its liposomes were evaluated in mice bearing H22 liver tumors. The pH-LPC-lips displayed the best tumor inhibitory effect. The optical imaging results indicated that Cy7-labeled pH-LPC-lips showed excellent hepatocyte specificity in H22 tumor-bearing mice. Therefore, pH-LPC-lips can be regarded as liver-targeting agents that combine targeting and active releasing.

语种英语
WOS记录号WOS:000311152700017
项目编号2007CB935800 ; 2009zx09310-001 ; BE2011670 ; 81273463
资助机构National Basic Research Program of China (973 Program) ; National Key Program of New Drug innovation ; Technology Support Program of Jiangsu Province ; National Natural Science Foundation of China ; Priority Academic Program Development of Jiangsu Higher Education Institutions
引用统计
被引频次:2[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/52173
专题北京大学药学院_药剂学系
作者单位1.Suzhou Hlth Coll, Suzhou 215009, Peoples R China
2.Changshu City Chinese Med Hosp, Changshu 215500, Peoples R China
3.Soochow Univ, Dept Pharmaceut, Coll Pharmaceut Sci, Suzhou 215123, Peoples R China
4.Peking Univ, Sch Pharmaceut Sci, Dept Pharmaceut, Beijing 100083, Peoples R China
推荐引用方式
GB/T 7714
Qiao-ling, Z.,Yi, Z.,Min, G.,et al. Hepatocyte-Targeted Delivery Using pH-Sensitive Liposomes Loaded with Lactosylnorcantharidin Phospholipid Complex: Preparation, Characterization, and Therapeutic Evaluation In Vivo and In Vitro[J]. CURRENT MEDICINAL CHEMISTRY,2012,19(33):5754-5763.
APA Qiao-ling, Z..,Yi, Z..,Min, G..,Di-jia, Y..,Xiao-feng, Z..,...&Qiang, Z..(2012).Hepatocyte-Targeted Delivery Using pH-Sensitive Liposomes Loaded with Lactosylnorcantharidin Phospholipid Complex: Preparation, Characterization, and Therapeutic Evaluation In Vivo and In Vitro.CURRENT MEDICINAL CHEMISTRY,19(33),5754-5763.
MLA Qiao-ling, Z.,et al."Hepatocyte-Targeted Delivery Using pH-Sensitive Liposomes Loaded with Lactosylnorcantharidin Phospholipid Complex: Preparation, Characterization, and Therapeutic Evaluation In Vivo and In Vitro".CURRENT MEDICINAL CHEMISTRY 19.33(2012):5754-5763.
条目包含的文件
条目无相关文件。
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[Qiao-ling, Z.]的文章
[Yi, Z.]的文章
[Min, G.]的文章
百度学术
百度学术中相似的文章
[Qiao-ling, Z.]的文章
[Yi, Z.]的文章
[Min, G.]的文章
必应学术
必应学术中相似的文章
[Qiao-ling, Z.]的文章
[Yi, Z.]的文章
[Min, G.]的文章
相关权益政策
暂无数据
收藏/分享
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。