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学科主题: 药学
题名:
Hepatocyte-Targeted Delivery Using pH-Sensitive Liposomes Loaded with Lactosylnorcantharidin Phospholipid Complex: Preparation, Characterization, and Therapeutic Evaluation In Vivo and In Vitro
作者: Qiao-ling, Z.1; Yi, Z.1; Min, G.1; Di-jia, Y.1,2; Xiao-feng, Z.1,3; Yang, L.1; Jing-yu, X.1; Ying, W.1; Zong-lin, G.1; Kong-lang, X.1; Ai-jun, Z.1; Wei-liang, C.1; Lin-sen, S.1; Xue-nong, Z.1; Qiang, Z.4
关键词: Hepatocyte-targeted delivery ; lactosyl-norcantharidin ; lipsomes ; pH sensitive ; phospholipid complex ; HepG2 cells ; release ; cytotoxicity ; cellular uptake ; near-infrared fluoressence
刊名: CURRENT MEDICINAL CHEMISTRY
发表日期: 2012-11-01
卷: 19, 期:33, 页:5754-5763
收录类别: SCI
文章类型: Review
WOS标题词: Science & Technology
类目[WOS]: Biochemistry & Molecular Biology ; Chemistry, Medicinal ; Pharmacology & Pharmacy
研究领域[WOS]: Biochemistry & Molecular Biology ; Pharmacology & Pharmacy
关键词[WOS]: DRUG-DELIVERY ; CANCER-THERAPY ; NANOPARTICLES ; NORCANTHARIDIN ; SIZE ; DIAGNOSIS ; RELEASE ; SYSTEMS
英文摘要:

Liposomes loaded with lactosyl-norcantharidin phospholipid complex (LPC) were prepared, in which soybean phosphatidylcholine was used to improve the liposolubility of lactosyl-norcantharidin (Lac-NCTD). The pH-sensitive LPC liposomes (pH-LPC-lips) were obtained by electrostatic adsorption of the carboxymethyl chitosan onto the surface of the liposomes. The in vitro drug release of pH-LPC-lips and LPC-lips was investigated in dissolution media with pH ranging from 1.0 to 8.0. The in vitro antitumor activity and cellular uptake of Lac-NCTD and its liposomes to HepG2 cells were studied. The pH-LPC-lips demonstrated strong cytotoxicity against the cells and easily permeated the cell membrane. The in vivo antitumor activities of Lac-NCTD and its liposomes were evaluated in mice bearing H22 liver tumors. The pH-LPC-lips displayed the best tumor inhibitory effect. The optical imaging results indicated that Cy7-labeled pH-LPC-lips showed excellent hepatocyte specificity in H22 tumor-bearing mice. Therefore, pH-LPC-lips can be regarded as liver-targeting agents that combine targeting and active releasing.

语种: 英语
所属项目编号: 2007CB935800 ; 2009zx09310-001 ; BE2011670 ; 81273463
项目资助者: National Basic Research Program of China (973 Program) ; National Key Program of New Drug innovation ; Technology Support Program of Jiangsu Province ; National Natural Science Foundation of China ; Priority Academic Program Development of Jiangsu Higher Education Institutions
WOS记录号: WOS:000311152700017
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/52173
Appears in Collections:北京大学药学院_药剂学系_期刊论文

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作者单位: 1.Suzhou Hlth Coll, Suzhou 215009, Peoples R China
2.Changshu City Chinese Med Hosp, Changshu 215500, Peoples R China
3.Soochow Univ, Dept Pharmaceut, Coll Pharmaceut Sci, Suzhou 215123, Peoples R China
4.Peking Univ, Sch Pharmaceut Sci, Dept Pharmaceut, Beijing 100083, Peoples R China

Recommended Citation:
Qiao-ling, Z.,Yi, Z.,Min, G.,et al. Hepatocyte-Targeted Delivery Using pH-Sensitive Liposomes Loaded with Lactosylnorcantharidin Phospholipid Complex: Preparation, Characterization, and Therapeutic Evaluation In Vivo and In Vitro[J]. CURRENT MEDICINAL CHEMISTRY,2012,19(33):5754-5763.
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