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学科主题: 临床医学
题名:
Plasma levels and potential roles of catestatin in patients with coronary heart disease
作者: Liu, Lin; Ding, Wenhui; Zhao, Feng; Shi, Libin; Pang, Yongzheng; Tang, Chaoshu
关键词: catestatin ; coronary heart disease ; norepinephrine
刊名: SCANDINAVIAN CARDIOVASCULAR JOURNAL
发表日期: 2013-08-01
DOI: 10.3109/14017431.2013.794951
卷: 47, 期:4, 页:217-224
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Cardiac & Cardiovascular Systems
研究领域[WOS]: Cardiovascular System & Cardiology
关键词[WOS]: INHIBITORY PEPTIDE CATESTATIN ; ACUTE MYOCARDIAL-INFARCTION ; CIRCULATING CHROMOGRANIN-A ; SYMPATHETIC-NERVOUS-SYSTEM ; BRAIN NATRIURETIC PEPTIDE ; CATECHOLAMINE RELEASE ; CARDIAC-FUNCTION ; HYPERTENSION ; MORTALITY ; FRAGMENT
英文摘要:

Objectives. Catestatin (CST) is a new endogenous neuropeptide with a potent catecholamine release-inhibitory activity. This study was to investigate plasma CST levels in patients with coronary heart disease (CHD) and to determine the clinical significance of plasma CST in cardiovascular events. Methods. A total of 120 CHD patients and 30 age/sex-matched healthy subjects were enrolled. Plasma CST level was measured using enzyme-linked immunosorbent assay (ELISA) and norepinephrine (NE) level was measured using high-performance liquid chromatography (HPLC). Clinical and laboratory data during hospitalization were collected, and a follow-up of 1045 days was carried out. Results. Compared with controls, CHD patients had significantly higher plasma CST and NE levels on admission. ST segment elevation myocardial infarction (STEMI) patients had higher CST levels than angina pectoris patients had, but CST/NE ratios were unchanged among controls and different CHD subgroups. Plasma NE was the only independent factor associated with CST. As a dichotomous variable divided by the median value, plasma CST on admission was not associated with adverse cardiovascular events. Conclusions. Plasma CST level was positively correlated with that of NE and was elevated in parallel with that of NE in the different myocardial ischemia states. Plasma CST on admission was neither associated with adverse cardiac events nor was there any significant relationship between plasma CST and onset of new cardiovascular events. The pathophysiological role of CST in CHD needs further studies.

语种: 英语
所属项目编号: 2009-3026 ; 20100001120136
项目资助者: Medical Development of the Capital ; Specialized Research Fund for the Doctoral Program of Higher Education of China
WOS记录号: WOS:000322607700004
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/52175
Appears in Collections:北京大学第一临床医学院_心血管内科_期刊论文

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作者单位: Peking Univ, Hosp 1, Dept Cardiol, Beijing 100034, Peoples R China

Recommended Citation:
Liu, Lin,Ding, Wenhui,Zhao, Feng,et al. Plasma levels and potential roles of catestatin in patients with coronary heart disease[J]. SCANDINAVIAN CARDIOVASCULAR JOURNAL,2013,47(4):217-224.
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