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学科主题临床医学
Plasma levels and potential roles of catestatin in patients with coronary heart disease
Liu, Lin; Ding, Wenhui; Zhao, Feng; Shi, Libin; Pang, Yongzheng; Tang, Chaoshu
关键词Catestatin Coronary Heart Disease Norepinephrine
刊名SCANDINAVIAN CARDIOVASCULAR JOURNAL
2013-08-01
DOI10.3109/14017431.2013.794951
47期:4页:217-224
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Cardiac & Cardiovascular Systems
研究领域[WOS]Cardiovascular System & Cardiology
关键词[WOS]INHIBITORY PEPTIDE CATESTATIN ; ACUTE MYOCARDIAL-INFARCTION ; CIRCULATING CHROMOGRANIN-A ; SYMPATHETIC-NERVOUS-SYSTEM ; BRAIN NATRIURETIC PEPTIDE ; CATECHOLAMINE RELEASE ; CARDIAC-FUNCTION ; HYPERTENSION ; MORTALITY ; FRAGMENT
英文摘要

Objectives. Catestatin (CST) is a new endogenous neuropeptide with a potent catecholamine release-inhibitory activity. This study was to investigate plasma CST levels in patients with coronary heart disease (CHD) and to determine the clinical significance of plasma CST in cardiovascular events. Methods. A total of 120 CHD patients and 30 age/sex-matched healthy subjects were enrolled. Plasma CST level was measured using enzyme-linked immunosorbent assay (ELISA) and norepinephrine (NE) level was measured using high-performance liquid chromatography (HPLC). Clinical and laboratory data during hospitalization were collected, and a follow-up of 1045 days was carried out. Results. Compared with controls, CHD patients had significantly higher plasma CST and NE levels on admission. ST segment elevation myocardial infarction (STEMI) patients had higher CST levels than angina pectoris patients had, but CST/NE ratios were unchanged among controls and different CHD subgroups. Plasma NE was the only independent factor associated with CST. As a dichotomous variable divided by the median value, plasma CST on admission was not associated with adverse cardiovascular events. Conclusions. Plasma CST level was positively correlated with that of NE and was elevated in parallel with that of NE in the different myocardial ischemia states. Plasma CST on admission was neither associated with adverse cardiac events nor was there any significant relationship between plasma CST and onset of new cardiovascular events. The pathophysiological role of CST in CHD needs further studies.

语种英语
WOS记录号WOS:000322607700004
引用统计
被引频次:13[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/52175
专题北京大学第一临床医学院_心血管内科
医学人文研究院/公共教学部_哲学与社会科学系
北京大学第三临床医学院_运动医学研究所
作者单位Peking Univ, Hosp 1, Dept Cardiol, Beijing 100034, Peoples R China
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GB/T 7714
Liu, Lin,Ding, Wenhui,Zhao, Feng,et al. Plasma levels and potential roles of catestatin in patients with coronary heart disease[J]. SCANDINAVIAN CARDIOVASCULAR JOURNAL,2013,47(4):217-224.
APA Liu, Lin,Ding, Wenhui,Zhao, Feng,Shi, Libin,Pang, Yongzheng,&Tang, Chaoshu.(2013).Plasma levels and potential roles of catestatin in patients with coronary heart disease.SCANDINAVIAN CARDIOVASCULAR JOURNAL,47(4),217-224.
MLA Liu, Lin,et al."Plasma levels and potential roles of catestatin in patients with coronary heart disease".SCANDINAVIAN CARDIOVASCULAR JOURNAL 47.4(2013):217-224.
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