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学科主题: 药学
题名:
Characterization of compounds from the roots of Saposhnikovia divaricata by high-performance liquid chromatography coupled with electrospray ionization tandem mass spectrometry
作者: Kang, Jie; Sun, Jiang-Hao; Zhou, Le; Ye, Min; Han, Jian; Wang, Bao-Rong; Guo, De-An
刊名: RAPID COMMUNICATIONS IN MASS SPECTROMETRY
发表日期: 2008-06-01
DOI: 10.1002/rcm.3559
卷: 22, 期:12, 页:1899-1911
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Chemistry, Analytical ; Spectroscopy
研究领域[WOS]: Chemistry ; Spectroscopy
关键词[WOS]: PRESSURE CHEMICAL-IONIZATION ; DIODE-ARRAY DETECTION ; DAD-ESI-MSN ; PHENOLIC-COMPOUNDS ; HPLC-DAD ; FINGERPRINT ANALYSIS ; SALVIA-MILTIORRHIZA ; CONSTITUENTS ; FLAVONOIDS ; EXTRACT
英文摘要:

In this study, four types of compounds including coumarins, chromones, furoylmethyl amino acid derivative and benzofuran glycoside were isolated from the roots of Saposhnikovia divaricata. The electrospray ionization (ESI) mass spectral fragmentation pathways of these compounds were proposed. In particular, the ESI-MSn fragmentation behavior of linear dihydrofurocoumarins, dihydrofuro- and dihydropyranochromones were deduced in detail. For the linear dihydrofurocoumarins, the fragmentation was triggered by the initial loss of the C-4′ substituting group. Then, the characteristic ions were observed followed by the losses of 15, 18, 28 and 46 Da. It is noteworthy that the elimination of H2O (18 Da) from the cleavage of the dihydrofuran ring is reported for the first time. For the linear dihydrofurochromones, characteristic eliminations of 18, 48 and 72 Da were observed. The loss of 18 Da could arise from two different fragmentation pathways, and the observed ion was composed of a mixture of two different structural ions. For the linear dihydropyranochromones, it was found that the dihydropyran ring was converted into the pyran ring by the elimination of the C-3′ substituting group. This fragmentation was followed by the diagnostic losses of 18, 28, 42 and 54 Da in tandem mass spectrometry. The above fragmentation rules were successfully applied for the analysis of the chemical constituents of the roots of Saposhnikovia divaricata. A total of 32 compounds were identified or tentatively characterized by HPLC/DAD/ESI-MSn. Among them, eight compounds were new and seven compounds were reported from that genus for the first time. Copyright (C) 2008 John Wiley & Sons, Ltd.

语种: 英语
WOS记录号: WOS:000256985100016
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/52177
Appears in Collections:北京大学药学院_期刊论文

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作者单位: Peking Univ, Hlth Sci Ctr, State Key Lab Nat & Biomimet Drugs, Sch Pharmaceut Sci, Beijing 100083, Peoples R China

Recommended Citation:
Kang, Jie,Sun, Jiang-Hao,Zhou, Le,et al. Characterization of compounds from the roots of Saposhnikovia divaricata by high-performance liquid chromatography coupled with electrospray ionization tandem mass spectrometry[J]. RAPID COMMUNICATIONS IN MASS SPECTROMETRY,2008,22(12):1899-1911.
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