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Characterization of compounds from the roots of Saposhnikovia divaricata by high-performance liquid chromatography coupled with electrospray ionization tandem mass spectrometry
Kang, Jie; Sun, Jiang-Hao; Zhou, Le; Ye, Min; Han, Jian; Wang, Bao-Rong; Guo, De-An
刊名RAPID COMMUNICATIONS IN MASS SPECTROMETRY
2008-06-01
DOI10.1002/rcm.3559
22期:12页:1899-1911
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Chemistry, Analytical ; Spectroscopy
研究领域[WOS]Chemistry ; Spectroscopy
关键词[WOS]PRESSURE CHEMICAL-IONIZATION ; DIODE-ARRAY DETECTION ; DAD-ESI-MSN ; PHENOLIC-COMPOUNDS ; HPLC-DAD ; FINGERPRINT ANALYSIS ; SALVIA-MILTIORRHIZA ; CONSTITUENTS ; FLAVONOIDS ; EXTRACT
英文摘要

In this study, four types of compounds including coumarins, chromones, furoylmethyl amino acid derivative and benzofuran glycoside were isolated from the roots of Saposhnikovia divaricata. The electrospray ionization (ESI) mass spectral fragmentation pathways of these compounds were proposed. In particular, the ESI-MSn fragmentation behavior of linear dihydrofurocoumarins, dihydrofuro- and dihydropyranochromones were deduced in detail. For the linear dihydrofurocoumarins, the fragmentation was triggered by the initial loss of the C-4′ substituting group. Then, the characteristic ions were observed followed by the losses of 15, 18, 28 and 46 Da. It is noteworthy that the elimination of H2O (18 Da) from the cleavage of the dihydrofuran ring is reported for the first time. For the linear dihydrofurochromones, characteristic eliminations of 18, 48 and 72 Da were observed. The loss of 18 Da could arise from two different fragmentation pathways, and the observed ion was composed of a mixture of two different structural ions. For the linear dihydropyranochromones, it was found that the dihydropyran ring was converted into the pyran ring by the elimination of the C-3′ substituting group. This fragmentation was followed by the diagnostic losses of 18, 28, 42 and 54 Da in tandem mass spectrometry. The above fragmentation rules were successfully applied for the analysis of the chemical constituents of the roots of Saposhnikovia divaricata. A total of 32 compounds were identified or tentatively characterized by HPLC/DAD/ESI-MSn. Among them, eight compounds were new and seven compounds were reported from that genus for the first time. Copyright (C) 2008 John Wiley & Sons, Ltd.

语种英语
WOS记录号WOS:000256985100016
引用统计
被引频次:33[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/52177
专题北京大学药学院
北京大学药学院_天然药物学系
作者单位Peking Univ, Hlth Sci Ctr, State Key Lab Nat & Biomimet Drugs, Sch Pharmaceut Sci, Beijing 100083, Peoples R China
推荐引用方式
GB/T 7714
Kang, Jie,Sun, Jiang-Hao,Zhou, Le,et al. Characterization of compounds from the roots of Saposhnikovia divaricata by high-performance liquid chromatography coupled with electrospray ionization tandem mass spectrometry[J]. RAPID COMMUNICATIONS IN MASS SPECTROMETRY,2008,22(12):1899-1911.
APA Kang, Jie.,Sun, Jiang-Hao.,Zhou, Le.,Ye, Min.,Han, Jian.,...&Guo, De-An.(2008).Characterization of compounds from the roots of Saposhnikovia divaricata by high-performance liquid chromatography coupled with electrospray ionization tandem mass spectrometry.RAPID COMMUNICATIONS IN MASS SPECTROMETRY,22(12),1899-1911.
MLA Kang, Jie,et al."Characterization of compounds from the roots of Saposhnikovia divaricata by high-performance liquid chromatography coupled with electrospray ionization tandem mass spectrometry".RAPID COMMUNICATIONS IN MASS SPECTROMETRY 22.12(2008):1899-1911.
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