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学科主题: 临床医学
题名:
Efficacy of Tetrandrine on Lowering Intraocular Pressure in Animal Model With Ocular Hypertension
作者: Huang, Ping1; Xu, Yongsheng1; Wei, Ruoxin1; Li, Haiping1; Tang, Yong1; Liu, Jing1; Zhang, Samuel Shao-Min2; Zhang, Chun1
关键词: tetrandrine ; eye drops ; animal model with ocular hypertension
刊名: JOURNAL OF GLAUCOMA
发表日期: 2011-03-01
DOI: 10.1097/IJG.0b013e3181d7882a
卷: 20, 期:3, 页:183-188
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Ophthalmology
研究领域[WOS]: Ophthalmology
关键词[WOS]: NONINVASIVE MEASUREMENT ; TRABECULAR MESHWORK ; CHANNEL BLOCKER ; GLAUCOMA ; MECHANISMS ; CELLS ; HERBS ; MICE
英文摘要:

Purpose: To compare the efficacy of topical tetrandrine (an alkaloid isolated from the Chinese medicinal herb Radix Stephania tetrandrae S) and timolol 0.5% ophthalmic solution on lowering the intraocular pressure (IOP) in ocular normotensive and hypertensive rats.

Methods: The experiment was designed as 2 parts. In the first part, normal male Sprague-Dawley rats were divided into 4 groups followed by topical administration once of 0.1%, 0.2%, 0.3% tetrandrine, and 0.5% timolol in the right eye, 0.9% saline was administered once at the opposite eye as control. In the second part, the ocular hypertension model was induced unilaterally in the rats by a diode laser treatment. Twice daily applications of the above drugs were delivered to hypertensive eyes. The control group was administered 0.9% saline. The TonoPen XL tonometer was used to determine the IOP levels.

Results: No lowering effect on IOP was detected in the normotensive rats treated with tetrandrine whereas timolol significantly reduced IOP in normotensive eyes. Both tetrandrine and timolol significantly reduced the IOP levels in the hypertensive eyes compared with the levels in the saline-treated groups. All concentrations of tetrandrine used in this study showed significant reduction of IOP in the laser-induced hypertensive eyes. Tetrandrine 0.3% had a similar efficacy as 0.5% timolol in reducing elevated IOP in ocular hypertensive eyes.

Conclusions: This study provides evidence that tetrandrine has a major effect on lowering IOP levels in the ocular hypertension rat model. The functional mechanisms of tetrandrine require further investigation.

语种: 英语
WOS记录号: WOS:000287960800009
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/52186
Appears in Collections:北京大学第三临床医学院_眼科_期刊论文

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作者单位: 1.Peking Univ, Peking Univ Hosp 3, Peking Univ Eye Ctr, Dept Opthalmol, Beijing 100191, Peoples R China
2.Penn State Univ, Coll Med, Dept Neural & Behav Sci, Hershey, PA USA

Recommended Citation:
Huang, Ping,Xu, Yongsheng,Wei, Ruoxin,et al. Efficacy of Tetrandrine on Lowering Intraocular Pressure in Animal Model With Ocular Hypertension[J]. JOURNAL OF GLAUCOMA,2011,20(3):183-188.
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