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Efficacy of Tetrandrine on Lowering Intraocular Pressure in Animal Model With Ocular Hypertension
Huang, Ping1; Xu, Yongsheng1; Wei, Ruoxin1; Li, Haiping1; Tang, Yong1; Liu, Jing1; Zhang, Samuel Shao-Min2; Zhang, Chun1
关键词Tetrandrine Eye Drops Animal Model With Ocular Hypertension
刊名JOURNAL OF GLAUCOMA
2011-03-01
DOI10.1097/IJG.0b013e3181d7882a
20期:3页:183-188
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Ophthalmology
研究领域[WOS]Ophthalmology
关键词[WOS]NONINVASIVE MEASUREMENT ; TRABECULAR MESHWORK ; CHANNEL BLOCKER ; GLAUCOMA ; MECHANISMS ; CELLS ; HERBS ; MICE
英文摘要

Purpose: To compare the efficacy of topical tetrandrine (an alkaloid isolated from the Chinese medicinal herb Radix Stephania tetrandrae S) and timolol 0.5% ophthalmic solution on lowering the intraocular pressure (IOP) in ocular normotensive and hypertensive rats.

Methods: The experiment was designed as 2 parts. In the first part, normal male Sprague-Dawley rats were divided into 4 groups followed by topical administration once of 0.1%, 0.2%, 0.3% tetrandrine, and 0.5% timolol in the right eye, 0.9% saline was administered once at the opposite eye as control. In the second part, the ocular hypertension model was induced unilaterally in the rats by a diode laser treatment. Twice daily applications of the above drugs were delivered to hypertensive eyes. The control group was administered 0.9% saline. The TonoPen XL tonometer was used to determine the IOP levels.

Results: No lowering effect on IOP was detected in the normotensive rats treated with tetrandrine whereas timolol significantly reduced IOP in normotensive eyes. Both tetrandrine and timolol significantly reduced the IOP levels in the hypertensive eyes compared with the levels in the saline-treated groups. All concentrations of tetrandrine used in this study showed significant reduction of IOP in the laser-induced hypertensive eyes. Tetrandrine 0.3% had a similar efficacy as 0.5% timolol in reducing elevated IOP in ocular hypertensive eyes.

Conclusions: This study provides evidence that tetrandrine has a major effect on lowering IOP levels in the ocular hypertension rat model. The functional mechanisms of tetrandrine require further investigation.

语种英语
WOS记录号WOS:000287960800009
引用统计
被引频次:15[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/52186
专题北京大学第三临床医学院_眼科
北京大学第三临床医学院_骨科
作者单位1.Peking Univ, Peking Univ Hosp 3, Peking Univ Eye Ctr, Dept Opthalmol, Beijing 100191, Peoples R China
2.Penn State Univ, Coll Med, Dept Neural & Behav Sci, Hershey, PA USA
推荐引用方式
GB/T 7714
Huang, Ping,Xu, Yongsheng,Wei, Ruoxin,et al. Efficacy of Tetrandrine on Lowering Intraocular Pressure in Animal Model With Ocular Hypertension[J]. JOURNAL OF GLAUCOMA,2011,20(3):183-188.
APA Huang, Ping.,Xu, Yongsheng.,Wei, Ruoxin.,Li, Haiping.,Tang, Yong.,...&Zhang, Chun.(2011).Efficacy of Tetrandrine on Lowering Intraocular Pressure in Animal Model With Ocular Hypertension.JOURNAL OF GLAUCOMA,20(3),183-188.
MLA Huang, Ping,et al."Efficacy of Tetrandrine on Lowering Intraocular Pressure in Animal Model With Ocular Hypertension".JOURNAL OF GLAUCOMA 20.3(2011):183-188.
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