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Upregulation of SIRT1 by 17 beta-estradiol depends on ubiquitin-proteasome degradation of PPAR-gamma mediated by NEDD4-1
Han, Limin1,2; Wang, Pan1,2; Zhao, Ganye1,2; Wang, Hui1,2; Wang, Meng1,2; Chen, Jun1,2; Tong, Tanjun1,2
关键词17 Beta-estradiol Ppar Gamma Senescence Sirt1 Ubiquitination
刊名PROTEIN & CELL
2013-04-01
DOI10.1007/s13238-013-2124-z
4期:4页:310-321
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Cell Biology
研究领域[WOS]Cell Biology
关键词[WOS]ACTIVATED RECEPTOR-GAMMA ; PROTEIN-KINASE ; SYSTEM CONTROLS ; PHOSPHORYLATION ; SENESCENCE ; ALPHA ; ADIPOGENESIS ; ADIPOCYTES ; EXPRESSION ; LIGANDS
英文摘要

17 beta-estradiol (E2) treatment of cells results in an upregulation of SIRT1 and a down-regulation of PPAR gamma. The decrease in PPAR gamma expression is mediated by increased degradation of PPAR gamma. Here we report that PPAR gamma is ubiquitinated by HECT E3 ubiquitin ligase NEDD4-1 and degraded, along with PPAR gamma, in response to E2 stimulation. The PPAR gamma interacts with ubiquitin ligase NEDD4-1 through a conserved PPXY-WW binding motif. The WW3 domain in NEDD4-1 is critical for binding to PPARI". NEDD4-1 overexpression leads to PPAR gamma ubiquitination and reduced expression of PPAR gamma. Conversely, knockdown of NEDD4-1 by specific siRNAs abolishes PPARI" ubiquitination. These data indicate that NEDD4-1 is the E3 ubiquitin ligase responsible for PPAR gamma ubiquitination. Here, we show that NEDD4-1 delays cellular senescence by degrading PPARI" expression. Taken together, our data show that E2 could upregulate SIRT1 expression via promoting the PPARI" ubiquitination-proteasome degradation pathway to delay the process of cell senescence.

语种英语
WOS记录号WOS:000317018000009
项目编号2012CB911203 ; 2013CB530801 ; 31100997 ; 20100470169
资助机构National Basic Research Programs of China ; National Natural Science Foundation of China ; China Postdoctoral Science Foundation
引用统计
被引频次:9[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/52187
专题北京大学基础医学院
作者单位1.Peking Univ, Hlth Sci Ctr, Peking Univ Res Ctr Aging, Beijing 100191, Peoples R China
2.Peking Univ, Hlth Sci Ctr, Sch Basic Med, Dept Biochem & Mol Biol, Beijing 100191, Peoples R China
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GB/T 7714
Han, Limin,Wang, Pan,Zhao, Ganye,et al. Upregulation of SIRT1 by 17 beta-estradiol depends on ubiquitin-proteasome degradation of PPAR-gamma mediated by NEDD4-1[J]. PROTEIN & CELL,2013,4(4):310-321.
APA Han, Limin.,Wang, Pan.,Zhao, Ganye.,Wang, Hui.,Wang, Meng.,...&Tong, Tanjun.(2013).Upregulation of SIRT1 by 17 beta-estradiol depends on ubiquitin-proteasome degradation of PPAR-gamma mediated by NEDD4-1.PROTEIN & CELL,4(4),310-321.
MLA Han, Limin,et al."Upregulation of SIRT1 by 17 beta-estradiol depends on ubiquitin-proteasome degradation of PPAR-gamma mediated by NEDD4-1".PROTEIN & CELL 4.4(2013):310-321.
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