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Liquid chromatographic-tandem mass spectrometric method for the simultaneous quantitation of telmisartan and hydrochlorothiazide in human plasma
Yan, Tingting2; Li, Hao2; Deng, Lili2; Guo, Yingjie2; Yu, Weisong2; Fawcett, J. Paul3; Zhang, Dan2; Cui, Yimin1; Gua, Jingkai2
关键词Telmisartan Hydrochlorothiazide Lc-ms/ms Pharmacokinetics Plasma
刊名JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
2008-12-01
DOI10.1016/j.jpba.2008.08.021
48期:4页:1225-1229
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Chemistry, Analytical ; Pharmacology & Pharmacy
研究领域[WOS]Chemistry ; Pharmacology & Pharmacy
关键词[WOS]HYPERTENSION
英文摘要

A rapid and sensitive method using liquid chromatography-tandem mass spectrometry (LC-MS/MS) has been developed for the simultaneous determination of telmisartan and hydrochlorothiazide in human plasma. Sample preparation involved liquid-liquid extraction with diethyl ether-dichloromethane (60:40. v/v). The analytes and internal standard, probenecid, were separated on a Venusil XBP-C(8) column using gradient elution with acetonitrile-10mM ammonium acetate-formic acid at a flow rate of 1.2mL/min. Detection was by electrospray negative ionization mass spectrometry using multiple reaction monitoring of the transitions at m/z 513.0 -> 469.4 for telmisartan, m/z 295.9 -> 268.9 for hydrochlorothiazide and m/z 283.9 -> 239.9 for probenecid. For both analytes, the method was linear in the range 1.00-600 ng/mL with intra- and inter-day precision (as relative standard deviation) <= 10.6% and accuracy (as relative error) <= 4.2%. The assay was successfully applied to a pharmacokinetic study in 9 healthy Volunteers given a single oral dose of a combination tablet containing telmisartan 80 mg and hydrochlorothiazide 12.5 mg. Crown Copyright (C) 2008 Published by Elsevier B.V. All rights reserved.

语种英语
WOS记录号WOS:000262622000025
引用统计
被引频次:25[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/52190
专题北京大学第一临床医学院_药剂科
作者单位1.Peking Univ, Hosp 1, Dept Pharm, Beijing 100034, Peoples R China
2.Univ Otago, Sch Pharm, Dunedin, New Zealand
3.Jilin Univ, Coll Life Sci, Res Ctr Drug Metab, Changchun 130021, Peoples R China
推荐引用方式
GB/T 7714
Yan, Tingting,Li, Hao,Deng, Lili,et al. Liquid chromatographic-tandem mass spectrometric method for the simultaneous quantitation of telmisartan and hydrochlorothiazide in human plasma[J]. JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS,2008,48(4):1225-1229.
APA Yan, Tingting.,Li, Hao.,Deng, Lili.,Guo, Yingjie.,Yu, Weisong.,...&Gua, Jingkai.(2008).Liquid chromatographic-tandem mass spectrometric method for the simultaneous quantitation of telmisartan and hydrochlorothiazide in human plasma.JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS,48(4),1225-1229.
MLA Yan, Tingting,et al."Liquid chromatographic-tandem mass spectrometric method for the simultaneous quantitation of telmisartan and hydrochlorothiazide in human plasma".JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS 48.4(2008):1225-1229.
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