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学科主题: 临床医学
题名:
Liquid chromatographic-tandem mass spectrometric method for the simultaneous quantitation of telmisartan and hydrochlorothiazide in human plasma
作者: Yan, Tingting2; Li, Hao2; Deng, Lili2; Guo, Yingjie2; Yu, Weisong2; Fawcett, J. Paul3; Zhang, Dan2; Cui, Yimin1; Gua, Jingkai2
关键词: Telmisartan ; Hydrochlorothiazide ; LC-MS/MS ; Pharmacokinetics ; Plasma
刊名: JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
发表日期: 2008-12-01
DOI: 10.1016/j.jpba.2008.08.021
卷: 48, 期:4, 页:1225-1229
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Chemistry, Analytical ; Pharmacology & Pharmacy
研究领域[WOS]: Chemistry ; Pharmacology & Pharmacy
关键词[WOS]: HYPERTENSION
英文摘要:

A rapid and sensitive method using liquid chromatography-tandem mass spectrometry (LC-MS/MS) has been developed for the simultaneous determination of telmisartan and hydrochlorothiazide in human plasma. Sample preparation involved liquid-liquid extraction with diethyl ether-dichloromethane (60:40. v/v). The analytes and internal standard, probenecid, were separated on a Venusil XBP-C(8) column using gradient elution with acetonitrile-10mM ammonium acetate-formic acid at a flow rate of 1.2mL/min. Detection was by electrospray negative ionization mass spectrometry using multiple reaction monitoring of the transitions at m/z 513.0 -> 469.4 for telmisartan, m/z 295.9 -> 268.9 for hydrochlorothiazide and m/z 283.9 -> 239.9 for probenecid. For both analytes, the method was linear in the range 1.00-600 ng/mL with intra- and inter-day precision (as relative standard deviation) <= 10.6% and accuracy (as relative error) <= 4.2%. The assay was successfully applied to a pharmacokinetic study in 9 healthy Volunteers given a single oral dose of a combination tablet containing telmisartan 80 mg and hydrochlorothiazide 12.5 mg. Crown Copyright (C) 2008 Published by Elsevier B.V. All rights reserved.

语种: 英语
WOS记录号: WOS:000262622000025
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/52190
Appears in Collections:北京大学第一临床医学院_药剂科_期刊论文

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作者单位: 1.Peking Univ, Hosp 1, Dept Pharm, Beijing 100034, Peoples R China
2.Univ Otago, Sch Pharm, Dunedin, New Zealand
3.Jilin Univ, Coll Life Sci, Res Ctr Drug Metab, Changchun 130021, Peoples R China

Recommended Citation:
Yan, Tingting,Li, Hao,Deng, Lili,et al. Liquid chromatographic-tandem mass spectrometric method for the simultaneous quantitation of telmisartan and hydrochlorothiazide in human plasma[J]. JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS,2008,48(4):1225-1229.
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