北京大学医学部机构知识库
Advanced  
IR@PKUHSC  > 北京大学精神卫生研究所  > 期刊论文
学科主题: 精神卫生
题名:
Altered baseline brain activity in children with ADHD revealed by resting-state functional MRI
作者: Zang Yu-Feng1; He Yong1; Zhu Chao-Zhe1; Cao Qing-Jiu1; Sui Man-Qiu1; Liang Meng1; Tian Li-Xia1; Jiang Tian-Zi1; Wang, Yu-Feng1
关键词: attention deficit hyperactivity disorder ; resting-state functional MRI ; amplitude ; low-frequency fluctuation ; spontaneous neuronal activity
刊名: BRAIN & DEVELOPMENT
发表日期: 2007-03-01
DOI: 10.1016/j.braindev.2006.07.002
卷: 29, 期:2, 页:83-91
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Clinical Neurology
研究领域[WOS]: Neurosciences & Neurology
关键词[WOS]: DEFICIT HYPERACTIVITY DISORDER ; ATTENTION-DEFICIT/HYPERACTIVITY DISORDER ; CEREBRAL-BLOOD-FLOW ; EVENT-RELATED FMRI ; MAGNETIC-RESONANCE ; RESPONSE-INHIBITION ; DEFAULT-MODE ; METHYLPHENIDATE ; CONNECTIVITY ; BOYS
英文摘要:

In children with attention deficit hyperactivity disorder (ADHD), functional neuroimaging studies have revealed abnormalities in various brain regions, including prefrontal-striatal circuit, cerebellum, and brainstem. In the current study, we used a new marker of functional magnetic resonance imaging (fMRI), amplitude of low-frequency (0.01-0.08 Hz) fluctuation (ALFF) to investigate the baseline brain function of this disorder. Thirteen boys with ADHD (13.0 +/- 1.4 years) were examined by resting-state fMRI and compared with age-matched controls. As a result, we found that patients with ADHD had decreased ALFF in the right inferior frontal cortex, left sensorimotor cortex, and bilateral cerebellum and the vermis as well as increased ALFF in the right anterior cingulated cortex, left sensorimotor cortex, and bilateral brainstem. This resting-state fMRI study suggests that the changed spontaneous neuronal activity of these regions may be implicated in the underlying pathophysiology in children with ADHD. (c) 2006 Elsevier B.V. All rights reserved.

语种: 英语
WOS记录号: WOS:000244380400005
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/52192
Appears in Collections:北京大学精神卫生研究所_期刊论文

Files in This Item:

There are no files associated with this item.


作者单位: 1.Peking Univ, Inst Mental Hlth, Beijing 100083, Peoples R China
2.Beijing Normal Univ, State Key Lab Cognit Neurosci & Learning, Beijing 100871, Peoples R China
3.Chinese Acad Sci, Inst Automat, Natl Lab Pattern Recognit, Beijing 100080, Peoples R China

Recommended Citation:
Zang Yu-Feng,He Yong,Zhu Chao-Zhe,et al. Altered baseline brain activity in children with ADHD revealed by resting-state functional MRI[J]. BRAIN & DEVELOPMENT,2007,29(2):83-91.
Service
Recommend this item
Sava as my favorate item
Show this item's statistics
Export Endnote File
Google Scholar
Similar articles in Google Scholar
[Zang Yu-Feng]'s Articles
[He Yong]'s Articles
[Zhu Chao-Zhe]'s Articles
CSDL cross search
Similar articles in CSDL Cross Search
[Zang Yu-Feng]‘s Articles
[He Yong]‘s Articles
[Zhu Chao-Zhe]‘s Articles
Related Copyright Policies
Null
Social Bookmarking
Add to CiteULike Add to Connotea Add to Del.icio.us Add to Digg Add to Reddit
所有评论 (0)
暂无评论
 
评注功能仅针对注册用户开放,请您登录
您对该条目有什么异议,请填写以下表单,管理员会尽快联系您。
内 容:
Email:  *
单位:
验证码:   刷新
您在IR的使用过程中有什么好的想法或者建议可以反馈给我们。
标 题:
 *
内 容:
Email:  *
验证码:   刷新

Items in IR are protected by copyright, with all rights reserved, unless otherwise indicated.

 

 

Valid XHTML 1.0!
Copyright © 2007-2017  北京大学医学部 - Feedback
Powered by CSpace