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Altered baseline brain activity in children with ADHD revealed by resting-state functional MRI
Zang Yu-Feng1; He Yong1; Zhu Chao-Zhe1; Cao Qing-Jiu1; Sui Man-Qiu1; Liang Meng1; Tian Li-Xia1; Jiang Tian-Zi1; Wang, Yu-Feng1
关键词Attention Deficit Hyperactivity Disorder Resting-state Functional Mri Amplitude Low-frequency Fluctuation Spontaneous Neuronal Activity
刊名BRAIN & DEVELOPMENT
2007-03-01
DOI10.1016/j.braindev.2006.07.002
29期:2页:83-91
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Clinical Neurology
研究领域[WOS]Neurosciences & Neurology
关键词[WOS]DEFICIT HYPERACTIVITY DISORDER ; ATTENTION-DEFICIT/HYPERACTIVITY DISORDER ; CEREBRAL-BLOOD-FLOW ; EVENT-RELATED FMRI ; MAGNETIC-RESONANCE ; RESPONSE-INHIBITION ; DEFAULT-MODE ; METHYLPHENIDATE ; CONNECTIVITY ; BOYS
英文摘要

In children with attention deficit hyperactivity disorder (ADHD), functional neuroimaging studies have revealed abnormalities in various brain regions, including prefrontal-striatal circuit, cerebellum, and brainstem. In the current study, we used a new marker of functional magnetic resonance imaging (fMRI), amplitude of low-frequency (0.01-0.08 Hz) fluctuation (ALFF) to investigate the baseline brain function of this disorder. Thirteen boys with ADHD (13.0 +/- 1.4 years) were examined by resting-state fMRI and compared with age-matched controls. As a result, we found that patients with ADHD had decreased ALFF in the right inferior frontal cortex, left sensorimotor cortex, and bilateral cerebellum and the vermis as well as increased ALFF in the right anterior cingulated cortex, left sensorimotor cortex, and bilateral brainstem. This resting-state fMRI study suggests that the changed spontaneous neuronal activity of these regions may be implicated in the underlying pathophysiology in children with ADHD. (c) 2006 Elsevier B.V. All rights reserved.

语种英语
WOS记录号WOS:000244380400005
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被引频次:695[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/52192
专题北京大学精神卫生研究所
作者单位1.Peking Univ, Inst Mental Hlth, Beijing 100083, Peoples R China
2.Beijing Normal Univ, State Key Lab Cognit Neurosci & Learning, Beijing 100871, Peoples R China
3.Chinese Acad Sci, Inst Automat, Natl Lab Pattern Recognit, Beijing 100080, Peoples R China
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GB/T 7714
Zang Yu-Feng,He Yong,Zhu Chao-Zhe,et al. Altered baseline brain activity in children with ADHD revealed by resting-state functional MRI[J]. BRAIN & DEVELOPMENT,2007,29(2):83-91.
APA Zang Yu-Feng.,He Yong.,Zhu Chao-Zhe.,Cao Qing-Jiu.,Sui Man-Qiu.,...&Wang, Yu-Feng.(2007).Altered baseline brain activity in children with ADHD revealed by resting-state functional MRI.BRAIN & DEVELOPMENT,29(2),83-91.
MLA Zang Yu-Feng,et al."Altered baseline brain activity in children with ADHD revealed by resting-state functional MRI".BRAIN & DEVELOPMENT 29.2(2007):83-91.
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