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学科主题: 临床医学
题名:
Antidiabetic Rosiglitazone Reduces Soluble Intercellular Adhesion Molecule-1 Level in Type 2 Diabetic Patients with Coronary Artery Disease
作者: Wang, Guang1; Zhang, Zhe2; Yu, Jie1; Zhang, Fuchun1; He, Liyun1; Wei, Jinru1; Mao, Jieming1; Wang, Xian1,3,4
刊名: PPAR RESEARCH
发表日期: 2008
DOI: 10.1155/2008/548178
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Medicine, Research & Experimental
研究领域[WOS]: Research & Experimental Medicine
英文摘要:

Background. We investigated the level of soluble adhesion molecules in diabetic patients and the effect of the peroxisome proliferator-activated receptor-gamma (PPAR-gamma) agonist rosiglitazone on plasma levels of adhesion molecules and an inflammation marker in type 2 diabetic patients with coronary artery disease (CAD) after percutaneous coronary intervention (PCI). Methods. A total of 116 diabetic patients with CAD who had undergone PCI were randomized to receive rosiglitazone (4mg/d) or not for 6 months. Plasma levels of soluble intercellular adhesion molecules (sICAM-1) and P-selectin (sP-selectin) were measured on ELISA. Results. After 6-month rosiglitazone treatment, plasma levels of sICAM-1 were lower than baseline and control group levels (370.4 (332.4-421.9) pg/mL versus 423.5 (327.4-500.3) pg/mL and 404.6 (345.2-483.4) pg/mL, P < .001). In addition, plasma levels of C-reactive protein were significantly reduced from baseline levels. However, plasma level of sP-selectin was not significantly lowered with rosiglitazone treatment than with control treatment after 6-month follow-up. Conclusions. Rosiglitazone reduces chronic inflammatory responses and improves levels of markers of endothelial dysfunction in patients with diabetes and CAD. PPAR-gamma agonist may have a beneficial effect on the vascular endothelium through its anti-inflammatory mechanism and may be useful as therapy in patients undergoing PCI. Copyright (C) 2008 GuangWang et al.

语种: 英语
所属项目编号: 2006CB503802 ; 30330250 ; 30770873
项目资助者: Major National Basic Research Program of the P. R. China ; Chinese National Natural Science Foundation
WOS记录号: WOS:000207691800001
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/52193
Appears in Collections:北京大学第三临床医学院_心血管内科_期刊论文

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作者单位: 1.Peking Univ, Hosp 3, Inst Vasc Med, Beijing 100191, Peoples R China
2.Peking Univ, Hosp 3, Dept Cardiovasc Surg, Beijing 100191, Peoples R China
3.Peking Univ, Dept Physiol & Pathophysiol, Hlth Sci Ctr, Beijing 100083, Peoples R China
4.Peking Univ, Key Lab Mol Cardiovasc Sci, Hlth Sci Ctr, Minist Educ, Beijing 100083, Peoples R China

Recommended Citation:
Wang, Guang,Zhang, Zhe,Yu, Jie,et al. Antidiabetic Rosiglitazone Reduces Soluble Intercellular Adhesion Molecule-1 Level in Type 2 Diabetic Patients with Coronary Artery Disease[J]. PPAR RESEARCH,2008.
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