IR@PKUHSC  > 北京大学第一临床医学院
学科主题临床医学
Circulating neutrophil gelatinase-associated lipocalin: a useful biomarker for assessing disease activity of ANCA-associated vasculitis
Chen, Min; Wang, Fang; Zhao, Ming-Hui
关键词Anti-neutrophil Cytoplasmic Autoantibody Vasculitis Neutrophil Gelatinase-associated Lipocalin
刊名RHEUMATOLOGY
2009-04-01
DOI10.1093/rheumatology/ken500
48期:4页:355-358
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Rheumatology
研究领域[WOS]Rheumatology
关键词[WOS]AUTOANTIBODY-ASSOCIATED VASCULITIS ; CHRONIC KIDNEY-DISEASE ; SYSTEMIC VASCULITIS ; CARDIAC-SURGERY ; RENAL INJURY ; ANTIBODIES ; MARKER ; NGAL ; PROTEINASE-3 ; PREDICTORS
英文摘要

Objectives. Biomarkers for assessing disease activity of patients with anti-neutrophil cytoplasmic autoantibody (ANCA)-associated vasculitis (AAV) are important in identifying relapse and guiding treatment. ANCA-induced neutrophil activation and degranulation played an important role in the pathogenesis of AAV and neutrophil gelatinase-associated lipocalin (NGAL) is a biomarker of neutrophil degranulation. The purpose of the current study is to investigate whether NGAL is a useful biomarker for assessing disease activity of patients with AAV.

Methods. Sequential sera from 19 patients with AAV at initial onset, remission and relapse were collected. Serum NGAL was detected using commercial ELISA kits. The association between serum NGAL and the Birmingham Vasculitis Activity Score (BVAS), ESR, CRP as well as serum ANCA was further investigated.

Results. The 19 patients had 19 relapses. The levels of serum NGAL in patients at initial onset and relapse were both significantly higher than that at remission (285.5 65.5 ng/ml vs 96.7 22.2 ng/ml, P 0.05; 430.3 98.7 ng/ml vs 96.7 22.2 ng/ml, P 0.05, respectively). It was still the case after adjusting for renal function. The levels of serum NGAL closely correlated with BVAS as well as the level of ESR, CRP and ANCA. Moreover, serum NGAL level had a closer correlation with BVAS than ESR, CRP and ANCA did.

Conclusion. Circulating NGAL could be used as a useful biomarker for assessing disease activity of patients with AAV.

语种英语
WOS记录号WOS:000264389000006
项目编号985-2-104-113
资助机构Chinese 985 project
引用统计
被引频次:11[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/52197
专题北京大学第一临床医学院
北京大学第一临床医学院_肾脏内科
作者单位Peking Univ, Hosp 1, Dept Med,Renal Div,Inst Nephrol, Key Lab Renal Dis,Minist Hlth China, Beijing 100034, Peoples R China
推荐引用方式
GB/T 7714
Chen, Min,Wang, Fang,Zhao, Ming-Hui. Circulating neutrophil gelatinase-associated lipocalin: a useful biomarker for assessing disease activity of ANCA-associated vasculitis[J]. RHEUMATOLOGY,2009,48(4):355-358.
APA Chen, Min,Wang, Fang,&Zhao, Ming-Hui.(2009).Circulating neutrophil gelatinase-associated lipocalin: a useful biomarker for assessing disease activity of ANCA-associated vasculitis.RHEUMATOLOGY,48(4),355-358.
MLA Chen, Min,et al."Circulating neutrophil gelatinase-associated lipocalin: a useful biomarker for assessing disease activity of ANCA-associated vasculitis".RHEUMATOLOGY 48.4(2009):355-358.
条目包含的文件
条目无相关文件。
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[Chen, Min]的文章
[Wang, Fang]的文章
[Zhao, Ming-Hui]的文章
百度学术
百度学术中相似的文章
[Chen, Min]的文章
[Wang, Fang]的文章
[Zhao, Ming-Hui]的文章
必应学术
必应学术中相似的文章
[Chen, Min]的文章
[Wang, Fang]的文章
[Zhao, Ming-Hui]的文章
相关权益政策
暂无数据
收藏/分享
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。