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学科主题: 临床医学
题名:
Circulating neutrophil gelatinase-associated lipocalin: a useful biomarker for assessing disease activity of ANCA-associated vasculitis
作者: Chen, Min; Wang, Fang; Zhao, Ming-Hui
关键词: Anti-neutrophil cytoplasmic autoantibody ; Vasculitis ; Neutrophil gelatinase-associated lipocalin
刊名: RHEUMATOLOGY
发表日期: 2009-04-01
DOI: 10.1093/rheumatology/ken500
卷: 48, 期:4, 页:355-358
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Rheumatology
研究领域[WOS]: Rheumatology
关键词[WOS]: AUTOANTIBODY-ASSOCIATED VASCULITIS ; CHRONIC KIDNEY-DISEASE ; SYSTEMIC VASCULITIS ; CARDIAC-SURGERY ; RENAL INJURY ; ANTIBODIES ; MARKER ; NGAL ; PROTEINASE-3 ; PREDICTORS
英文摘要:

Objectives. Biomarkers for assessing disease activity of patients with anti-neutrophil cytoplasmic autoantibody (ANCA)-associated vasculitis (AAV) are important in identifying relapse and guiding treatment. ANCA-induced neutrophil activation and degranulation played an important role in the pathogenesis of AAV and neutrophil gelatinase-associated lipocalin (NGAL) is a biomarker of neutrophil degranulation. The purpose of the current study is to investigate whether NGAL is a useful biomarker for assessing disease activity of patients with AAV.

Methods. Sequential sera from 19 patients with AAV at initial onset, remission and relapse were collected. Serum NGAL was detected using commercial ELISA kits. The association between serum NGAL and the Birmingham Vasculitis Activity Score (BVAS), ESR, CRP as well as serum ANCA was further investigated.

Results. The 19 patients had 19 relapses. The levels of serum NGAL in patients at initial onset and relapse were both significantly higher than that at remission (285.5 65.5 ng/ml vs 96.7 22.2 ng/ml, P 0.05; 430.3 98.7 ng/ml vs 96.7 22.2 ng/ml, P 0.05, respectively). It was still the case after adjusting for renal function. The levels of serum NGAL closely correlated with BVAS as well as the level of ESR, CRP and ANCA. Moreover, serum NGAL level had a closer correlation with BVAS than ESR, CRP and ANCA did.

Conclusion. Circulating NGAL could be used as a useful biomarker for assessing disease activity of patients with AAV.

语种: 英语
所属项目编号: 985-2-104-113
项目资助者: Chinese 985 project
WOS记录号: WOS:000264389000006
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/52197
Appears in Collections:北京大学第一临床医学院_期刊论文

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作者单位: Peking Univ, Hosp 1, Dept Med,Renal Div,Inst Nephrol, Key Lab Renal Dis,Minist Hlth China, Beijing 100034, Peoples R China

Recommended Citation:
Chen, Min,Wang, Fang,Zhao, Ming-Hui. Circulating neutrophil gelatinase-associated lipocalin: a useful biomarker for assessing disease activity of ANCA-associated vasculitis[J]. RHEUMATOLOGY,2009,48(4):355-358.
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