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学科主题公共卫生
Cinnabar is Different from Mercuric Chloride in Mercury Absorption and Influence on the Brain Serotonin Level
Wang, Qi1; Yang, Xiaoda2; Zhang, Baoxu1; Yang, Xiuwei2; Wang, Kui2
刊名BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY
2013-06-01
DOI10.1111/bcpt.12045
112期:6页:412-417
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Pharmacology & Pharmacy ; Toxicology
资助者National Natural Science Foundation of China ; National Key technologies R&amp ; D program of China ; Committee of Science and Technology of Beijing ; National Natural Science Foundation of China ; National Key technologies R&amp ; D program of China ; Committee of Science and Technology of Beijing
研究领域[WOS]Pharmacology & Pharmacy ; Toxicology
关键词[WOS]ATOMIC FLUORESCENCE SPECTROMETRY ; INORGANIC MERCURY ; TRADITIONAL MEDICINES ; RAT-BRAIN ; MICE ; SPECIATION ; DOPAMINE ; TOXICITY ; SULFIDE ; PLASMA
英文摘要

The toxicity of cinnabar, a naturally occurring mercury sulphide (HgS), has long been referred to soluble mercury chloride (HgCl2). To investigate whether the speciation of mercury plays a role in its disposition and toxicity, we hereby investigated and compared cinnabar with soluble HgCl2 and pure insoluble HgS in mice on mercury absorption, tissue distribution and in relation to the biological effects. The male C57BL/6J mice were treated by oral administration of various doses of cinnabar, with 0.01g/kg of HgCl2 for comparison, or the same dose of cinnabar or pure HgS (0.1g/kg), once a day for 10 consecutive days. The total mercury contents in serum and tissue (brain, kidney, liver) were measured by atomic fluorescence spectrometer (AFS). The biological effects investigated involved monoamine neurotransmitters (serotonin, 5-HT) in brain as an indicator of therapeutic function, and serum alanine transaminase (ALT) as a marker of hepatic damage, blood urea nitrogen (BUN) and serum creatinine as markers for renal function. The mercury absorption of cinnabar or HgS was much less than that of HgCl2. The mercury levels in brains of the cinnabar group were only slightly changed and kept in a steady-state with the dose elevated. Cinnabar or HgS suppressed brain 5-HT levels. HgCl2 could not cause any changes in brain 5-HT although the mercury level increased considerably. The results revealed that cinnabar or HgS is markedly different from HgCl2 in mercury absorption, tissue distribution and influence on brain 5-HT levels, which suggests that the pharmacological and/or toxicological effects of cinnabar undertake other pathways from mercuric ions.

语种英语
所属项目编号30672653 ; 2001BA701A57 ; Z0004105040311
资助者National Natural Science Foundation of China ; National Key technologies R&amp ; D program of China ; Committee of Science and Technology of Beijing ; National Natural Science Foundation of China ; National Key technologies R&amp ; D program of China ; Committee of Science and Technology of Beijing
WOS记录号WOS:000319212100006
Citation statistics
Cited Times:5[WOS]   [WOS Record]     [Related Records in WOS]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/52199
Collection北京大学公共卫生学院_毒理学系
作者单位1.Peking Univ, Sch Publ Hlth, Dept Toxicol, Beijing 100191, Peoples R China
2.Peking Univ, Sch Pharmaceut Sci, State Key Labs Nat & Biomimet Drugs, Beijing 100191, Peoples R China
Recommended Citation
GB/T 7714
Wang, Qi,Yang, Xiaoda,Zhang, Baoxu,et al. Cinnabar is Different from Mercuric Chloride in Mercury Absorption and Influence on the Brain Serotonin Level[J]. BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY,2013,112(6):412-417.
APA Wang, Qi,Yang, Xiaoda,Zhang, Baoxu,Yang, Xiuwei,&Wang, Kui.(2013).Cinnabar is Different from Mercuric Chloride in Mercury Absorption and Influence on the Brain Serotonin Level.BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY,112(6),412-417.
MLA Wang, Qi,et al."Cinnabar is Different from Mercuric Chloride in Mercury Absorption and Influence on the Brain Serotonin Level".BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY 112.6(2013):412-417.
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