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学科主题: 公共卫生
题名:
Cinnabar is Different from Mercuric Chloride in Mercury Absorption and Influence on the Brain Serotonin Level
作者: Wang, Qi1; Yang, Xiaoda2; Zhang, Baoxu1; Yang, Xiuwei2; Wang, Kui2
刊名: BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY
发表日期: 2013-06-01
DOI: 10.1111/bcpt.12045
卷: 112, 期:6, 页:412-417
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Pharmacology & Pharmacy ; Toxicology
研究领域[WOS]: Pharmacology & Pharmacy ; Toxicology
关键词[WOS]: ATOMIC FLUORESCENCE SPECTROMETRY ; INORGANIC MERCURY ; TRADITIONAL MEDICINES ; RAT-BRAIN ; MICE ; SPECIATION ; DOPAMINE ; TOXICITY ; SULFIDE ; PLASMA
英文摘要:

The toxicity of cinnabar, a naturally occurring mercury sulphide (HgS), has long been referred to soluble mercury chloride (HgCl2). To investigate whether the speciation of mercury plays a role in its disposition and toxicity, we hereby investigated and compared cinnabar with soluble HgCl2 and pure insoluble HgS in mice on mercury absorption, tissue distribution and in relation to the biological effects. The male C57BL/6J mice were treated by oral administration of various doses of cinnabar, with 0.01g/kg of HgCl2 for comparison, or the same dose of cinnabar or pure HgS (0.1g/kg), once a day for 10 consecutive days. The total mercury contents in serum and tissue (brain, kidney, liver) were measured by atomic fluorescence spectrometer (AFS). The biological effects investigated involved monoamine neurotransmitters (serotonin, 5-HT) in brain as an indicator of therapeutic function, and serum alanine transaminase (ALT) as a marker of hepatic damage, blood urea nitrogen (BUN) and serum creatinine as markers for renal function. The mercury absorption of cinnabar or HgS was much less than that of HgCl2. The mercury levels in brains of the cinnabar group were only slightly changed and kept in a steady-state with the dose elevated. Cinnabar or HgS suppressed brain 5-HT levels. HgCl2 could not cause any changes in brain 5-HT although the mercury level increased considerably. The results revealed that cinnabar or HgS is markedly different from HgCl2 in mercury absorption, tissue distribution and influence on brain 5-HT levels, which suggests that the pharmacological and/or toxicological effects of cinnabar undertake other pathways from mercuric ions.

语种: 英语
所属项目编号: 30672653 ; 2001BA701A57 ; Z0004105040311
项目资助者: National Natural Science Foundation of China ; National Key technologies R&amp ; D program of China ; Committee of Science and Technology of Beijing
WOS记录号: WOS:000319212100006
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/52199
Appears in Collections:北京大学公共卫生学院_毒理学系_期刊论文

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作者单位: 1.Peking Univ, Sch Publ Hlth, Dept Toxicol, Beijing 100191, Peoples R China
2.Peking Univ, Sch Pharmaceut Sci, State Key Labs Nat & Biomimet Drugs, Beijing 100191, Peoples R China

Recommended Citation:
Wang, Qi,Yang, Xiaoda,Zhang, Baoxu,et al. Cinnabar is Different from Mercuric Chloride in Mercury Absorption and Influence on the Brain Serotonin Level[J]. BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY,2013,112(6):412-417.
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