|Folic acid supplementation with and without vitamin B6 and revascularization risk: A meta-analysis of randomized controlled trials|
|Qin, Xianhui1,2; Fan, Fangfang3; Cui, Yimin4; Chen, Fang5; Chen, Yundai6; Cheng, Xiaoshu7; Li, Yuming8,9; Wang, Binyan1; Xu, Xin10; Xu, Xiping10; Huo, Yong3; Wang, Xiaobin11|
|关键词||Folic Acid Supplementation Revascularization Risk Randomized Controlled Trials Meta-analysis|
|WOS标题词||Science & Technology|
|类目[WOS]||Nutrition & Dietetics|
|研究领域[WOS]||Nutrition & Dietetics|
|关键词[WOS]||HOMOCYSTEINE-LOWERING THERAPY ; STAGE RENAL-DISEASE ; PERCUTANEOUS CORONARY INTERVENTION ; ACUTE MYOCARDIAL-INFARCTION ; CARDIOVASCULAR-DISEASE ; B-VITAMINS ; STROKE PREVENTION ; SECONDARY PREVENTION ; VASCULAR-DISEASE ; TOTAL MORTALITY|
Background & aims: There is a growing amount of data and a continuing controversy over the effect of folic acid supplementation with and without vitamin B6 on revascularization risk.
Methods: We conducted a meta-analysis based on up-to-date published relevant randomized trials to further examine this issue. Relative risk (RR) was used to measure the effect of folic acid supplementation on risk of revascularization using a random-effects model. Total revascularization was defined as any arterial revascularization. Restenosis was defined as stenosis of more than 50 percent of the luminal diameter.
Results: Overall, folic acid supplementation had no significant effect on coronary revascularization (9 trials, n = 27,418, RR = 0.99; 95%CI:0.88-1.11, P = 0.88), coronary artery bypass grafting (CABG) (5 trials, n = 10,703, 0.90; 0.79-1.03, P = 0.11), percutaneous coronary intervention (PCI) (5 trials, n = 10,703, 1.05; 0.89-1.23, P = 0.59), coronary restenosis (3 trials, n = 926, 1.05; 0.89-1.23, P = 0.59) or total revascularization (7 trials, n = 29,314, 1.06; 95%CI: 0.99-1.13, P = 0.10). However, a greater beneficial effect was observed for coronary revascularization among those trials with a moderate dose of vitamin B6 (5-10 mg/d; RR: 0.47; 95%CI: 0.28-0.80, P = 0.005), but not in trials without vitamin B6 or with a high dose of vitamin B6. And a non-significant greater total revascularization risk was observed in trials with a higher folic acid dose (>2 mg/d, RR = 1.11; 95%CI: 0.98-1.25, P = 0.09; >= 5 mg/d, RR = 1.98; 95%CI: 0.93-4.20, P = 0.08).
Conclusions: Our analyses indicate that folic acid supplementation has no significant effect on coronary revascularization, CABG, PCI, coronary restenosis or total revascularization. However, a combination of folic acid and moderate vitamin B6 may be beneficial in reducing coronary revascularization risk. (C) 2014 Elsevier Ltd and European Society for Clinical Nutrition and Metabolism. All rights reserved.
|项目编号||2012CB517703 ; 2012zx09101-105|
|资助机构||Major State Basic Research Development Program of China (973 program) ; Ministry of Science and Technology of the People&prime ; s Republic of China|
|作者单位||1.Anhui Med Univ, Inst Biomed, Hefei, Peoples R China|
2.Peking Univ, Hosp 1, Dept Pharm, Beijing 100871, Peoples R China
3.Southern Med Univ, Nanfang Hosp, Div Nephrol, Guangzhou, Guangdong, Peoples R China
4.Peking Univ, Hosp 1, Dept Cardiol, Beijing 100871, Peoples R China
5.Capital Med Univ, Beijing Anzhen Hosp, Dept Cardiol, Beijing, Peoples R China
6.Peoples Liberat Army Gen Hosp, Dept Cardiol, Beijing, Peoples R China
7.Nanchang Univ, Affiliated Hosp 2, Dept Cardiol, Nanchang, Peoples R China
8.Chinese Peoples Armed Police Forces, Inst Cardiovasc Dis, Tianjin, Peoples R China
9.Chinese Peoples Armed Police Forces, Ctr Heart, Pinjing Hosp Logist Univ, Tianjin, Peoples R China
10.Southern Med Univ, Guangdong Inst Nephrol, Guangzhou, Guangdong, Peoples R China
11.Johns Hopkins Univ, Bloomberg Sch Publ Hlth, Ctr Early Life Origins Dis, Dept Populat Family & Reprod Hlth, Baltimore, MD USA
|Qin, Xianhui,Fan, Fangfang,Cui, Yimin,et al. Folic acid supplementation with and without vitamin B6 and revascularization risk: A meta-analysis of randomized controlled trials[J]. CLINICAL NUTRITION,2014,33(4):603-612.|
|APA||Qin, Xianhui.,Fan, Fangfang.,Cui, Yimin.,Chen, Fang.,Chen, Yundai.,...&Wang, Xiaobin.(2014).Folic acid supplementation with and without vitamin B6 and revascularization risk: A meta-analysis of randomized controlled trials.CLINICAL NUTRITION,33(4),603-612.|
|MLA||Qin, Xianhui,et al."Folic acid supplementation with and without vitamin B6 and revascularization risk: A meta-analysis of randomized controlled trials".CLINICAL NUTRITION 33.4(2014):603-612.|