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学科主题临床医学
Elevated serum cystatin C is an independent predictor of cardiovascular events in people with relatively normal renal function
Meng, Lei1; Yang, Ying1; Qi, Li-Tong1; Wang, Xue-jing2; Xu, Guo-Bin2; Zhang, Bao-Wei1
关键词Cardiovascular Events Cystatin c Predictor
刊名JOURNAL OF NEPHROLOGY
2012-05-01
DOI10.5301/jn.5000020
25期:3页:426-430
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Urology & Nephrology
研究领域[WOS]Urology & Nephrology
关键词[WOS]CHRONIC KIDNEY-DISEASE ; GLOMERULAR-FILTRATION-RATE ; CORONARY-HEART-DISEASE ; ELDERLY PERSONS ; OLDER-ADULTS ; RISK ; OUTCOMES ; FAILURE ; MARKER ; DEATH
英文摘要

Background: Serum level of cystatin C could predict morbidity and mortality for cardiovascular disease in patients with coronary heart disease. However, the predictive value of cystatin C for cardiovascular events in subjects with relatively normal renal function, especially in Asian populations, has rarely been investigated. The current study investigated the relationship between cystatin C and cardiovascular events in a community-based population in Beijing.

Methods: Residents (n=724) with relatively normal renal function (estimated glomerular filtration rate [eGFR] >= 60 ml/min per 1.73 m(2)), who attended a community hospital in an urban district of Beijing, were recruited in the study. Risk factors for cardiovascular events were analyzed.

Results: Compared with subjects without cardiovascular events, those with cardiovascular events were older (p<0.000001) and had a higher proportion of males (p<0.01), those with diabetes (p<0.05) and smokers (p<0.05). Subjects with cardiovascular events had lower levels of serum high-density lipoprotein cholesterol (HDL-C) and eGFR than those without (p<0.05, p<0.01, respectively). The serum level of cystatin C was significantly higher in subjects with cardiovascular events than in subjects without cardiovascular events (p<0.01). Multivariable logistic regression analysis showed that the independent predictors of cardiovascular events were age, hypertension and serum level of cystatin C (higher than 0.88mg/L).

Conclusions: Besides the traditional risk factors, a higher level of serum cystatin C might be another independent risk factor for cardiovascular events, even in those with relatively normal renal function.

语种英语
WOS记录号WOS:000306096600019
引用统计
被引频次:12[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/52206
专题北京大学第一临床医学院_心血管内科
作者单位1.Peking Univ, Hosp 1, Dept Cardiol, Beijing 100034, Peoples R China
2.Peking Univ, Hosp 1, Dept Clin Lab, Beijing 100034, Peoples R China
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GB/T 7714
Meng, Lei,Yang, Ying,Qi, Li-Tong,et al. Elevated serum cystatin C is an independent predictor of cardiovascular events in people with relatively normal renal function[J]. JOURNAL OF NEPHROLOGY,2012,25(3):426-430.
APA Meng, Lei,Yang, Ying,Qi, Li-Tong,Wang, Xue-jing,Xu, Guo-Bin,&Zhang, Bao-Wei.(2012).Elevated serum cystatin C is an independent predictor of cardiovascular events in people with relatively normal renal function.JOURNAL OF NEPHROLOGY,25(3),426-430.
MLA Meng, Lei,et al."Elevated serum cystatin C is an independent predictor of cardiovascular events in people with relatively normal renal function".JOURNAL OF NEPHROLOGY 25.3(2012):426-430.
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