北京大学医学部机构知识库
Advanced  
IR@PKUHSC  > 北京大学第一临床医学院  > 心血管内科  > 期刊论文
学科主题: 临床医学
题名:
Elevated serum cystatin C is an independent predictor of cardiovascular events in people with relatively normal renal function
作者: Meng, Lei1; Yang, Ying1; Qi, Li-Tong1; Wang, Xue-jing2; Xu, Guo-Bin2; Zhang, Bao-Wei1
关键词: Cardiovascular events ; Cystatin C ; Predictor
刊名: JOURNAL OF NEPHROLOGY
发表日期: 2012-05-01
DOI: 10.5301/jn.5000020
卷: 25, 期:3, 页:426-430
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Urology & Nephrology
研究领域[WOS]: Urology & Nephrology
关键词[WOS]: CHRONIC KIDNEY-DISEASE ; GLOMERULAR-FILTRATION-RATE ; CORONARY-HEART-DISEASE ; ELDERLY PERSONS ; OLDER-ADULTS ; RISK ; OUTCOMES ; FAILURE ; MARKER ; DEATH
英文摘要:

Background: Serum level of cystatin C could predict morbidity and mortality for cardiovascular disease in patients with coronary heart disease. However, the predictive value of cystatin C for cardiovascular events in subjects with relatively normal renal function, especially in Asian populations, has rarely been investigated. The current study investigated the relationship between cystatin C and cardiovascular events in a community-based population in Beijing.

Methods: Residents (n=724) with relatively normal renal function (estimated glomerular filtration rate [eGFR] >= 60 ml/min per 1.73 m(2)), who attended a community hospital in an urban district of Beijing, were recruited in the study. Risk factors for cardiovascular events were analyzed.

Results: Compared with subjects without cardiovascular events, those with cardiovascular events were older (p<0.000001) and had a higher proportion of males (p<0.01), those with diabetes (p<0.05) and smokers (p<0.05). Subjects with cardiovascular events had lower levels of serum high-density lipoprotein cholesterol (HDL-C) and eGFR than those without (p<0.05, p<0.01, respectively). The serum level of cystatin C was significantly higher in subjects with cardiovascular events than in subjects without cardiovascular events (p<0.01). Multivariable logistic regression analysis showed that the independent predictors of cardiovascular events were age, hypertension and serum level of cystatin C (higher than 0.88mg/L).

Conclusions: Besides the traditional risk factors, a higher level of serum cystatin C might be another independent risk factor for cardiovascular events, even in those with relatively normal renal function.

语种: 英语
WOS记录号: WOS:000306096600019
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/52206
Appears in Collections:北京大学第一临床医学院_心血管内科_期刊论文

Files in This Item:

There are no files associated with this item.


作者单位: 1.Peking Univ, Hosp 1, Dept Cardiol, Beijing 100034, Peoples R China
2.Peking Univ, Hosp 1, Dept Clin Lab, Beijing 100034, Peoples R China

Recommended Citation:
Meng, Lei,Yang, Ying,Qi, Li-Tong,et al. Elevated serum cystatin C is an independent predictor of cardiovascular events in people with relatively normal renal function[J]. JOURNAL OF NEPHROLOGY,2012,25(3):426-430.
Service
Recommend this item
Sava as my favorate item
Show this item's statistics
Export Endnote File
Google Scholar
Similar articles in Google Scholar
[Meng, Lei]'s Articles
[Yang, Ying]'s Articles
[Qi, Li-Tong]'s Articles
CSDL cross search
Similar articles in CSDL Cross Search
[Meng, Lei]‘s Articles
[Yang, Ying]‘s Articles
[Qi, Li-Tong]‘s Articles
Related Copyright Policies
Null
Social Bookmarking
Add to CiteULike Add to Connotea Add to Del.icio.us Add to Digg Add to Reddit

Items in IR are protected by copyright, with all rights reserved, unless otherwise indicated.

 

 

Valid XHTML 1.0!
Copyright © 2007-2017  北京大学医学部 - Feedback
Powered by CSpace