|Elevated serum cystatin C is an independent predictor of cardiovascular events in people with relatively normal renal function|
|Meng, Lei1; Yang, Ying1; Qi, Li-Tong1; Wang, Xue-jing2; Xu, Guo-Bin2; Zhang, Bao-Wei1|
|关键词||Cardiovascular Events Cystatin c Predictor|
|刊名||JOURNAL OF NEPHROLOGY|
|WOS标题词||Science & Technology|
|类目[WOS]||Urology & Nephrology|
|研究领域[WOS]||Urology & Nephrology|
|关键词[WOS]||CHRONIC KIDNEY-DISEASE ; GLOMERULAR-FILTRATION-RATE ; CORONARY-HEART-DISEASE ; ELDERLY PERSONS ; OLDER-ADULTS ; RISK ; OUTCOMES ; FAILURE ; MARKER ; DEATH|
Background: Serum level of cystatin C could predict morbidity and mortality for cardiovascular disease in patients with coronary heart disease. However, the predictive value of cystatin C for cardiovascular events in subjects with relatively normal renal function, especially in Asian populations, has rarely been investigated. The current study investigated the relationship between cystatin C and cardiovascular events in a community-based population in Beijing.
Methods: Residents (n=724) with relatively normal renal function (estimated glomerular filtration rate [eGFR] >= 60 ml/min per 1.73 m(2)), who attended a community hospital in an urban district of Beijing, were recruited in the study. Risk factors for cardiovascular events were analyzed.
Results: Compared with subjects without cardiovascular events, those with cardiovascular events were older (p<0.000001) and had a higher proportion of males (p<0.01), those with diabetes (p<0.05) and smokers (p<0.05). Subjects with cardiovascular events had lower levels of serum high-density lipoprotein cholesterol (HDL-C) and eGFR than those without (p<0.05, p<0.01, respectively). The serum level of cystatin C was significantly higher in subjects with cardiovascular events than in subjects without cardiovascular events (p<0.01). Multivariable logistic regression analysis showed that the independent predictors of cardiovascular events were age, hypertension and serum level of cystatin C (higher than 0.88mg/L).
Conclusions: Besides the traditional risk factors, a higher level of serum cystatin C might be another independent risk factor for cardiovascular events, even in those with relatively normal renal function.
|作者单位||1.Peking Univ, Hosp 1, Dept Cardiol, Beijing 100034, Peoples R China|
2.Peking Univ, Hosp 1, Dept Clin Lab, Beijing 100034, Peoples R China
|Meng, Lei,Yang, Ying,Qi, Li-Tong,et al. Elevated serum cystatin C is an independent predictor of cardiovascular events in people with relatively normal renal function[J]. JOURNAL OF NEPHROLOGY,2012,25(3):426-430.|
|APA||Meng, Lei,Yang, Ying,Qi, Li-Tong,Wang, Xue-jing,Xu, Guo-Bin,&Zhang, Bao-Wei.(2012).Elevated serum cystatin C is an independent predictor of cardiovascular events in people with relatively normal renal function.JOURNAL OF NEPHROLOGY,25(3),426-430.|
|MLA||Meng, Lei,et al."Elevated serum cystatin C is an independent predictor of cardiovascular events in people with relatively normal renal function".JOURNAL OF NEPHROLOGY 25.3(2012):426-430.|