IR@PKUHSC  > 北京大学深圳医院
学科主题临床医学
Susceptibility of Ureaplasma urealyticum to Methylene Blue-Mediated Photodynamic Antimicrobial Chemotherapy: An invitro Study
Ye, Tinglu1; Chen, Bancheng1; Yu, Bo1; Zhong, Qili1; Huang, Guoxin1; Hu, Xiaoping1; Zhang, Wei2
刊名PHOTOCHEMISTRY AND PHOTOBIOLOGY
2015-07-01
DOI10.1111/php.12438
91期:4页:917-922
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Biochemistry & Molecular Biology ; Biophysics
研究领域[WOS]Biochemistry & Molecular Biology ; Biophysics
关键词[WOS]ANTIBIOTIC SUSCEPTIBILITY ; CLINICAL-APPLICATIONS ; BIOFILM FORMATION ; THERAPY ; PACT ; PHOTOSENSITIZERS ; INACTIVATION ; MYCOPLASMAS ; BIOVARS ; PARVUM
英文摘要

The aim of this study was to detect the susceptibility of Ureaplasma urealyticum to methylene blue-mediated photodynamic antimicrobial chemotherapy (PACT). Three U.urealyticum strains including the standard serotype 1 and 5, and a clinically collected strain were used in this study. Strains were first incubated in 96-well culture plates in the presence of methylene blue with decreasing concentrations (from 1 to 0.015625mgmL(-1)) for 20 or 60min, and then submitted to irradiation with a light-emitting diode laser with a power density of 100mWcm(-2) for 8, 17, 34 or 68min. Regrowth of the strains was performed soon after irradiation. A significant inactivation effect was observed after PACT. Longer incubation time induced more extensive inactivation of U.urealyticum. No difference in response to PACT was observed between the two biovars of U.urealyticum. It was concluded that PACT had a significant inactivation effect on U.urealyticum, and it might be a promising alternative treatment for resistant U.urealyticum infections.

语种英语
WOS记录号WOS:000357373700019
项目编号201401025
资助机构Shenzhen health and family planning system scientific research project of Shenzhen city, Guangdong province, China
引用统计
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/52212
专题北京大学深圳医院
作者单位1.Peking Univ, Shenzhen Hosp, Dermatol Dept, Shenzhen, Peoples R China
2.Shenzhen PKU HKUST Med Ctr, Biomed Res Inst, Shenzhen, Peoples R China
推荐引用方式
GB/T 7714
Ye, Tinglu,Chen, Bancheng,Yu, Bo,et al. Susceptibility of Ureaplasma urealyticum to Methylene Blue-Mediated Photodynamic Antimicrobial Chemotherapy: An invitro Study[J]. PHOTOCHEMISTRY AND PHOTOBIOLOGY,2015,91(4):917-922.
APA Ye, Tinglu.,Chen, Bancheng.,Yu, Bo.,Zhong, Qili.,Huang, Guoxin.,...&Zhang, Wei.(2015).Susceptibility of Ureaplasma urealyticum to Methylene Blue-Mediated Photodynamic Antimicrobial Chemotherapy: An invitro Study.PHOTOCHEMISTRY AND PHOTOBIOLOGY,91(4),917-922.
MLA Ye, Tinglu,et al."Susceptibility of Ureaplasma urealyticum to Methylene Blue-Mediated Photodynamic Antimicrobial Chemotherapy: An invitro Study".PHOTOCHEMISTRY AND PHOTOBIOLOGY 91.4(2015):917-922.
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