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学科主题: 临床医学
题名:
Susceptibility of Ureaplasma urealyticum to Methylene Blue-Mediated Photodynamic Antimicrobial Chemotherapy: An invitro Study
作者: Ye, Tinglu1; Chen, Bancheng1; Yu, Bo1; Zhong, Qili1; Huang, Guoxin1; Hu, Xiaoping1; Zhang, Wei2
刊名: PHOTOCHEMISTRY AND PHOTOBIOLOGY
发表日期: 2015-07-01
DOI: 10.1111/php.12438
卷: 91, 期:4, 页:917-922
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Biochemistry & Molecular Biology ; Biophysics
研究领域[WOS]: Biochemistry & Molecular Biology ; Biophysics
关键词[WOS]: ANTIBIOTIC SUSCEPTIBILITY ; CLINICAL-APPLICATIONS ; BIOFILM FORMATION ; THERAPY ; PACT ; PHOTOSENSITIZERS ; INACTIVATION ; MYCOPLASMAS ; BIOVARS ; PARVUM
英文摘要:

The aim of this study was to detect the susceptibility of Ureaplasma urealyticum to methylene blue-mediated photodynamic antimicrobial chemotherapy (PACT). Three U.urealyticum strains including the standard serotype 1 and 5, and a clinically collected strain were used in this study. Strains were first incubated in 96-well culture plates in the presence of methylene blue with decreasing concentrations (from 1 to 0.015625mgmL(-1)) for 20 or 60min, and then submitted to irradiation with a light-emitting diode laser with a power density of 100mWcm(-2) for 8, 17, 34 or 68min. Regrowth of the strains was performed soon after irradiation. A significant inactivation effect was observed after PACT. Longer incubation time induced more extensive inactivation of U.urealyticum. No difference in response to PACT was observed between the two biovars of U.urealyticum. It was concluded that PACT had a significant inactivation effect on U.urealyticum, and it might be a promising alternative treatment for resistant U.urealyticum infections.

语种: 英语
所属项目编号: 201401025
项目资助者: Shenzhen health and family planning system scientific research project of Shenzhen city, Guangdong province, China
WOS记录号: WOS:000357373700019
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/52212
Appears in Collections:北京大学深圳医院_期刊论文

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作者单位: 1.Peking Univ, Shenzhen Hosp, Dermatol Dept, Shenzhen, Peoples R China
2.Shenzhen PKU HKUST Med Ctr, Biomed Res Inst, Shenzhen, Peoples R China

Recommended Citation:
Ye, Tinglu,Chen, Bancheng,Yu, Bo,et al. Susceptibility of Ureaplasma urealyticum to Methylene Blue-Mediated Photodynamic Antimicrobial Chemotherapy: An invitro Study[J]. PHOTOCHEMISTRY AND PHOTOBIOLOGY,2015,91(4):917-922.
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