北京大学医学部机构知识库
Advanced  
IR@PKUHSC  > 北京大学精神卫生研究所  > 期刊论文
学科主题: 精神卫生
题名:
Apolipoprotein E epsilon 4 Modulates Cognitive Profiles, Hippocampal Volume, and Resting-State Functional Connectivity in Alzheimer′s Disease
作者: Wang, Xiao1,3; Wang, Jinhui2,4,5,6,7; He, Yi1,3; Li, Huiying1,3; Yuan, Huishu8; Evans, Alan9; Yu, Xin1,3; He, Yong2,4,5; Wang, Huali1,3
关键词: Apolipoprotein E ; default-mode ; functional connectivity ; hippocampus ; resting-state functional MRI
刊名: JOURNAL OF ALZHEIMERS DISEASE
发表日期: 2015
DOI: 10.3233/JAD-142556
卷: 45, 期:3, 页:781-795
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Neurosciences
研究领域[WOS]: Neurosciences & Neurology
关键词[WOS]: DEFAULT-MODE NETWORK ; MEDIAL TEMPORAL-LOBE ; APOE GENOTYPE ; RECOGNITION MEMORY ; BRAIN ACTIVITY ; PREMORBID INTELLIGENCE ; PERIRHINAL CORTEX ; SEMANTIC MEMORY ; AMYLOID BURDEN ; CORTICAL HUBS
英文摘要:

The apolipoprotein E epsilon 4 (APOE epsilon 4) allele is a well-established genetic risk factor for Alzheimer′s disease (AD). Numerous studies have suggested that the modulation of APOE epsilon 4 affects cognition and brain structure and function in healthy populations, particularly in the hippocampus, a key area associated with AD pathology. However, the effect of APOE epsilon 4 allele on cognitive performance, hippocampal structural morphology, and specifically on functional characteristics in patients with AD remains poorly understood. Here, we employed a neuropsychological battery test and multi-modal structural MRI and resting-state functional MRI dataset to systematically investigate cognitive performance, hippocampal structural volume, and functional properties (including local low-frequency oscillating amplitude, intra-regional functional synchrony, and inter-regional functional connectivity) in 16 APOE epsilon 4-carriers and 26 non-carriers at early stages of AD. Compared to non-carriers, APOE epsilon 4-carriers exhibited poorer performance on recognition performance, but performed better on the late item generation of the verbal fluency task (associated with executive function). Structural imaging analysis revealed that APOE epsilon 4-carriers exhibited smaller left hippocampal volumes compared to non-carriers, and the result remains significant after correcting for effects of brain size. Functional imaging analysis revealed that APOE epsilon 4-carriers exhibited decreased amplitude of low-frequency fluctuations in the left hippocampus, non-significant changes in intra-regional synchronization within the hippocampus and decreased hippocampal functional connectivity predominantly in components of the default-mode network including the medial frontal and parietal cortices and the lateral temporal cortical regions. Taken together, our results showed APOE genotypic effects on the cognitive profile and hippocampal structural and functional characteristics in patients at early stages of AD, thus providing empirical evidence for the modulation of the APOE genotype on disease phenotype.

语种: 英语
所属项目编号: 2014CB846102 ; 30971044 ; 81030028 ; 81171018 ; 31221 003 ; 2007AA02Z421 ; Z111107067311036 ; 81225012 ; 1R21AG02818001A2 ; LZ13C09 0001
项目资助者: National Key Basic Research Program of China ; Natural Science Foundation of China ; High-Tech R&amp ; D Program, Ministry of Science &amp ; Technology, China ; Beijing Natural Science Foundation ; National Science Fund for Distinguished Young Scholars ; National Institute on Aging and Fogarty International Center ; State Key Laboratory of Cognitive Neuroscience and Learning, Beijing Normal University ; Zhejiang Provincial Natural Science Foundation of China
WOS记录号: WOS:000351608700010
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/52214
Appears in Collections:北京大学精神卫生研究所_期刊论文

Files in This Item:

There are no files associated with this item.


作者单位: 1.Peking Univ, Inst Mental Hlth, Dementia Care & Res Ctr, Beijing 100191, Peoples R China
2.Peking Univ, Key Lab Mental Hlth, Minist Hlth, Beijing 100191, Peoples R China
3.Beijing Municipal Key Lab Translat Res Diag & Tre, Beijing, Peoples R China
4.Beijing Normal Univ, State Key Lab Cognit Neurosci & Learning, Beijing 100875, Peoples R China
5.Beijing Normal Univ, IDG McGovern Inst Brain Res, Beijing 100875, Peoples R China
6.Hangzhou Normal Univ, Ctr Cognit & Brain Disorders, Hangzhou, Zhejiang, Peoples R China
7.Zhejiang Key Lab Res Assessment Cognit Impairment, Hangzhou, Zhejiang, Peoples R China
8.Peking Univ, Hosp 3, Dept Radiol, Beijing 100191, Peoples R China
9.McGill Univ, McConnell Brain Imaging Ctr, Montreal Neurol Inst, Montreal, PQ, Canada

Recommended Citation:
Wang, Xiao,Wang, Jinhui,He, Yi,et al. Apolipoprotein E epsilon 4 Modulates Cognitive Profiles, Hippocampal Volume, and Resting-State Functional Connectivity in Alzheimer′s Disease[J]. JOURNAL OF ALZHEIMERS DISEASE,2015,45(3):781-795.
Service
Recommend this item
Sava as my favorate item
Show this item's statistics
Export Endnote File
Google Scholar
Similar articles in Google Scholar
[Wang, Xiao]'s Articles
[Wang, Jinhui]'s Articles
[He, Yi]'s Articles
CSDL cross search
Similar articles in CSDL Cross Search
[Wang, Xiao]‘s Articles
[Wang, Jinhui]‘s Articles
[He, Yi]‘s Articles
Related Copyright Policies
Null
Social Bookmarking
Add to CiteULike Add to Connotea Add to Del.icio.us Add to Digg Add to Reddit

Items in IR are protected by copyright, with all rights reserved, unless otherwise indicated.

 

 

Valid XHTML 1.0!
Copyright © 2007-2017  北京大学医学部 - Feedback
Powered by CSpace