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学科主题: 临床医学
题名:
Relationship between the renal apparent diffusion coefficient and glomerular filtration rate: Preliminary experience
作者: Xu, Yufeng; Wang, Xiaoying; Jiang, Xuexiang
关键词: kidney ; glomerular filtration rate ; MRI ; diffusion-weighted imaging ; function imaging
刊名: JOURNAL OF MAGNETIC RESONANCE IMAGING
发表日期: 2007-09-01
DOI: 10.1002/jmri.20979
卷: 26, 期:3, 页:678-681
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Radiology, Nuclear Medicine & Medical Imaging
研究领域[WOS]: Radiology, Nuclear Medicine & Medical Imaging
关键词[WOS]: KIDNEY ; PERFUSION ; MRI
英文摘要:

Purpose: To investigate the relationship between ADC values measured by diffusion-weighted MRI (DWI) and the split glomerular filtration rate (GFR).

Materials and Methods: DWI (b = 0 and 500 seconds/mm(2)) was performed with a 1.5T MR unit in 55 patients. The ADCs were calculated with ROIs positioned in the renal parenchyma, and the split GFRs were measured by Tc-99(m)-DTPA scintigraphy using Gates′ method. The I 10 kidneys were divided into four groups: normal renal function (GFR 40 mL . minute(-1)), mild renal impairment (40 > GFR >= 20 mL . minute(-1)), moderate renal impairment (20 > GFR >= 10 mL . nimute(-1)), and severe renal impairment (GFR < 10 mL . minute(-1)). The renal ADCs between four groups were statistically compared by analysis of variance (ANOVA), and the relationship between ADCs and GFR was examined using Pearson′s correlation test.

Results: The mean renal ADCs of the four groups were 2.87 +/- 0.11, 2.55 +/- 0.17, 2.29 +/- 0.10, and 2.20 +/- 0.11 x 10(-3)mm(2)/second, respectively. There was a statistically significant difference in renal ADCs among the four groups (P < 0.001). There was a positive correlation between the ADCs and split GFR (r = 0.709).

Conclusion: The ADCs were significantly lower in impaired kidneys than in normal kidneys, and there was a positive correlation between the ADCs and GFR.

语种: 英语
WOS记录号: WOS:000249257300027
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/52215
Appears in Collections:北京大学第一临床医学院_放射治疗科_期刊论文

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作者单位: Peking Univ, Hosp 1, Dept Radiol, Beijing 100871, Peoples R China

Recommended Citation:
Xu, Yufeng,Wang, Xiaoying,Jiang, Xuexiang. Relationship between the renal apparent diffusion coefficient and glomerular filtration rate: Preliminary experience[J]. JOURNAL OF MAGNETIC RESONANCE IMAGING,2007,26(3):678-681.
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