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学科主题: 临床医学
题名:
Characteristics of Chinese patients with Wegener′s granulomatosis with anti-myeloperoxidase autoantibodies
作者: Chen, M1; Yu, F1; Zhang, Y1; Zou, WZ1; Zhao, MH1; Wang, HY1
关键词: Wegener&prime ; s granulomatosis ; ANCA ; vasculitides ; myeloperoxidase
刊名: KIDNEY INTERNATIONAL
发表日期: 2005-11-01
卷: 68, 期:5, 页:2225-2229
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Urology & Nephrology
研究领域[WOS]: Urology & Nephrology
关键词[WOS]: ANTINEUTROPHIL CYTOPLASMIC ANTIBODIES ; SYSTEMIC VASCULITIDES ; MYELOPEROXIDASE ; ANCA
英文摘要:

Characteristics of Chinese patients with Wegener′s granulomatosis with anti-myeloperoxidase autoantibodies.

Background. Cytoplasmic antineutrophil cytoplasmic autoantibodies (cANCA)/proteinase-3(PR3)-ANCA was considered the serologic diagnostic marker for Wegener′s granulomatosis (WG). However, Chinese patients with MPO-ANCA positive WG were frequently diagnosed. We now analyze the characteristics of patients with MPO-ANCA positive WG and investigate the difference between patients with MPO-ANCA and PR3-ANCA.

Methods. Patients with WG were selected according to both Chapel Hill Consensus Conference definition and American College of Rheumatology (ACR) classification criteria in 500 Chinese patients with ANCA-associated systemic vasculitides. The clinical manifestions were compared between patients with MPO-ANCA and with PR3-ANCA.

Results. Eight-nine patients fulfilled the diagnostic criteria of WG: 54/89(60.7%) were MPO-ANCA positive, 34/89(38.2%) were PR3-ANCA positive. Patients with MPO-ANCA were predominantly female compared with patients with PR3-ANCA. Patients with MPO-ANCA also had multisystem involvement. However, the prevalences of arthagia, skin rash, ophthalmic and ear involvement were significantly lower in patients with MPO-ANCA than those in patients with PR3-ANCA (46.3% vs. 70.6%, P < 0.05; 20.4% vs. 44.1%, P < 0.05; 27.8% vs. 58.8%, P < 0.01; 40.7% vs. 67.6%, P < 0.05, respectively). The prevalence of elevated initial serum creatinine was significantly higher in patients with MPO-ANCA than that in patients with PR3-ANCA (81.5% vs. 61.8%, chi(2)= 4.20, P < 0.05).

Conclusion. Patients with MPO-ANCA positive WG were not rare in Chinese.

语种: 英语
WOS记录号: WOS:000232388800058
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/52216
Appears in Collections:北京大学第一临床医学院_肾脏内科_期刊论文

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作者单位: 1.Peking Univ, Hosp 1, Div Renal, Beijing 100034, Peoples R China
2.Peking Univ, Hosp 1, Inst Nephrol, Beijing 100034, Peoples R China

Recommended Citation:
Chen, M,Yu, F,Zhang, Y,et al. Characteristics of Chinese patients with Wegener&prime;s granulomatosis with anti-myeloperoxidase autoantibodies[J]. KIDNEY INTERNATIONAL,2005,68(5):2225-2229.
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