IR@PKUHSC  > 北京大学临床肿瘤学院  > 肿瘤内科
学科主题临床医学
Effects of thalidomide on the expression of angiogenesis growth factors in human A(549) lung adenocarcinoma cells
Li, XP1; Liu, XY1; Wang, J1; Wang, ZL1; Jiang, W1; Reed, E1; Zhang, Y1; Liu, YL1; Li, QQ1
关键词Thalidomide Lung Cancer Vegf Fgf Angiogenesis
刊名INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE
2003-06-01
11期:6页:785-790
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Medicine, Research & Experimental
研究领域[WOS]Research & Experimental Medicine
关键词[WOS]PHASE-II ; FACTOR RECEPTORS ; BREAST-CANCER ; REGULATORS ; CARCINOMAS ; BFGF
英文摘要

Angiogenesis is a critical step for the growth and metastasis of solid tumors, and it is a major therapeutic target for the development of anti-angiogenics for cancer treatment. Thalidomide is reported to be an anti-angiogenic agent, which is currently in phase II clinical trials for the treatment of advanced malignancies. However, the mechanism of thalidomide in angiogenesis is not completely understood. This study was undertaken to investigate the effect of thalidomide on the expression of angiogenesis growth factors in human lung cancer cells. In this report, we show that thalidomide downregulated the mRNA and protein expression of basic fibroblast growth factor (bFGF) in the human lung adenocarcinoma cell line A(549), and that the effect of thalidomide was time and concentration-dependent. In contrast, the expression of vascular endothelial growth factor (VEGF) by thalidomide in these cells was in two phases. The mRNA and protein expression of VEGF was increased in the lung cancer cells treated with 0.6-6 mug/ml thalidomide, while higher concentrations of thalidomide decreased VEGF levels significantly in these cells. These data suggest that the antiangiogenic or antitumor activity. of thalidomide may be partly mediated through the regulation of the levels of angiogenesis growth factors.

语种英语
WOS记录号WOS:000182961700017
引用统计
被引频次:14[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/52217
专题北京大学临床肿瘤学院_肿瘤内科
作者单位1.W Virginia Univ, Robert C Byrd Hlth Sci Ctr, Mary Babb Randolph Canc Ctr, Morgantown, WV 26506 USA
2.W Virginia Univ, Robert C Byrd Hlth Sci Ctr, Dept Microbiol Immunol & Cell Biol, Morgantown, WV 26506 USA
3.Sichuan Univ, Dept Resp Med, Huaxi Hosp, Huaxi Med Ctr, Chengdu 610041, Peoples R China
4.Peking Univ, Dept Med, Sch Oncol, Beijing 100036, Peoples R China
5.Acad Mil Med Sci, Inst Basic Res, Beijing 100850, Peoples R China
推荐引用方式
GB/T 7714
Li, XP,Liu, XY,Wang, J,et al. Effects of thalidomide on the expression of angiogenesis growth factors in human A(549) lung adenocarcinoma cells[J]. INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE,2003,11(6):785-790.
APA Li, XP.,Liu, XY.,Wang, J.,Wang, ZL.,Jiang, W.,...&Li, QQ.(2003).Effects of thalidomide on the expression of angiogenesis growth factors in human A(549) lung adenocarcinoma cells.INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE,11(6),785-790.
MLA Li, XP,et al."Effects of thalidomide on the expression of angiogenesis growth factors in human A(549) lung adenocarcinoma cells".INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE 11.6(2003):785-790.
条目包含的文件
条目无相关文件。
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[Li, XP]的文章
[Liu, XY]的文章
[Wang, J]的文章
百度学术
百度学术中相似的文章
[Li, XP]的文章
[Liu, XY]的文章
[Wang, J]的文章
必应学术
必应学术中相似的文章
[Li, XP]的文章
[Liu, XY]的文章
[Wang, J]的文章
相关权益政策
暂无数据
收藏/分享
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。