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Altered expression of Autism-associated genes in the brain of Fragile X mouse model
Zhang, Aiying2; Shen, Chang-Hui1,3; Ma, Shuang Yong4; Ke, Yang2,5; El Idrissi, Abdeslem1,5
关键词Autism Fragile X WNT2 MECP2 FMR1 Mutagegesis Real-time PCR
刊名BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
2009-02-20
DOI10.1016/j.bbrc.2008.12.172
379期:4页:920-923
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Biochemistry & Molecular Biology ; Biophysics
研究领域[WOS]Biochemistry & Molecular Biology ; Biophysics
关键词[WOS]SENSORIMOTOR GATING ABNORMALITIES ; SPECTRUM DISORDERS ; MICE ; MALES ; GENETICS ; MECP2 ; WNT2
英文摘要

Autism is a severe neurodevelopmental disorder, which typically emerges in early childhood. Most cases of autism have not been linked to mutations in a specific gene, and the etioloty of the disorder remains to be established [S.S. Moy, J.J. Nadler, T.R. Magnuson, J.N. Crawley, Mouse models of autism spectrum disorders: the challenge for behavioral genetics, Am. J. Med. Genet. 142 (2006) 40-51]. Fragile X syndrome is caused by mutation in the FMR1 gene and is characterized by mental retardation, physical abnormalities, and, in most case, autistic-like behavior [R.J. Hagerman, A.W. Jackson, A. Levitas, B. Rimland, M. Braden, An analysis of autism in fifty males with the Fragile X syndrome, Am. J. Med. Genet. 23 (1986) 359-374, C.E. Bakker, C. Verheij, R. Willemsen, R. van der Heim, F. Oerlemans, M. Vermeij, A. Bygrave, A.T. Hoogeveen, B.A. Oostra, E. Reyniers, K De Boulle, R. D′Hooge, P. Cras, D. van Velzen, G. Nagels, J.J. Marti, P. De Deyn, J.K. Darby, P.J. Willems, Fmr1 knockout mice: a model to study Fragile X mental retardation, Cell 78 (1994) 23-33]. The FMR1 knockout (KC) mouse is one of the best characterized animal models for human disorders associated with autism [S.S. Moy,J.J. Nadler, T.R. Magnuson,J.N. Crawley, Mouse models Of autism spectrum disorders: the challenge for behavioral genetics, Am. J. Med. Genet. 142 (2006) 40-51]. We have used real-time PCR to investigate changes in expression levels of three genes: WNT2, MECP2, and FMR1 in different brain regions of Fagile X mice and litter mate controls. We found major changes in the expression pattern for the three genes examined. FMR1, MECP2, and WNT2 expression were drastically down regulated in the Fragile X mouse brain. (C) 2009 Elsevier Inc. All rights reserved.

语种英语
WOS记录号WOS:000263336700023
资助机构China Scholar Council (CSC) ; The Fragile X Research Foundation (FRAXA) ; The College of Staten Island ; PSC-CUNY
引用统计
被引频次:22[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
版本出版稿
条目标识符http://ir.bjmu.edu.cn/handle/400002259/52220
专题北京大学基础医学院_医学遗传学系
北京大学临床肿瘤学院_遗传学研究室
作者单位1.CUNY, Dept Biol, Coll Staten Isl, Staten Isl, NY 10314 USA
2.Peking Univ, Dept Genet, Hlth Sci Ctr, Beijing 100083, Peoples R China
3.CUNY, Inst Mol Assemblies, Staten Isl, NY 10314 USA
4.New York State Inst Basic Res Dev Disabil, Dept Dev Neurobiol, Staten Isl, NY 10314 USA
5.Ctr Dev Neurosci, Staten Isl, NY 10314 USA
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Zhang, Aiying,Shen, Chang-Hui,Ma, Shuang Yong,et al. Altered expression of Autism-associated genes in the brain of Fragile X mouse model[J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,2009,379(4):920-923.
APA Zhang, Aiying,Shen, Chang-Hui,Ma, Shuang Yong,Ke, Yang,&El Idrissi, Abdeslem.(2009).Altered expression of Autism-associated genes in the brain of Fragile X mouse model.BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,379(4),920-923.
MLA Zhang, Aiying,et al."Altered expression of Autism-associated genes in the brain of Fragile X mouse model".BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 379.4(2009):920-923.
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