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学科主题: 基础医学
题名:
Altered expression of Autism-associated genes in the brain of Fragile X mouse model
作者: Zhang, Aiying2; Shen, Chang-Hui1,3; Ma, Shuang Yong4; Ke, Yang2,5; El Idrissi, Abdeslem1,5
关键词: Autism ; Fragile X ; WNT2 ; MECP2 ; FMR1 ; Mutagegesis ; Real-time PCR
刊名: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
发表日期: 2009-02-20
DOI: 10.1016/j.bbrc.2008.12.172
卷: 379, 期:4, 页:920-923
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Biochemistry & Molecular Biology ; Biophysics
研究领域[WOS]: Biochemistry & Molecular Biology ; Biophysics
关键词[WOS]: SENSORIMOTOR GATING ABNORMALITIES ; SPECTRUM DISORDERS ; MICE ; MALES ; GENETICS ; MECP2 ; WNT2
英文摘要:

Autism is a severe neurodevelopmental disorder, which typically emerges in early childhood. Most cases of autism have not been linked to mutations in a specific gene, and the etioloty of the disorder remains to be established [S.S. Moy, J.J. Nadler, T.R. Magnuson, J.N. Crawley, Mouse models of autism spectrum disorders: the challenge for behavioral genetics, Am. J. Med. Genet. 142 (2006) 40-51]. Fragile X syndrome is caused by mutation in the FMR1 gene and is characterized by mental retardation, physical abnormalities, and, in most case, autistic-like behavior [R.J. Hagerman, A.W. Jackson, A. Levitas, B. Rimland, M. Braden, An analysis of autism in fifty males with the Fragile X syndrome, Am. J. Med. Genet. 23 (1986) 359-374, C.E. Bakker, C. Verheij, R. Willemsen, R. van der Heim, F. Oerlemans, M. Vermeij, A. Bygrave, A.T. Hoogeveen, B.A. Oostra, E. Reyniers, K De Boulle, R. D′Hooge, P. Cras, D. van Velzen, G. Nagels, J.J. Marti, P. De Deyn, J.K. Darby, P.J. Willems, Fmr1 knockout mice: a model to study Fragile X mental retardation, Cell 78 (1994) 23-33]. The FMR1 knockout (KC) mouse is one of the best characterized animal models for human disorders associated with autism [S.S. Moy,J.J. Nadler, T.R. Magnuson,J.N. Crawley, Mouse models Of autism spectrum disorders: the challenge for behavioral genetics, Am. J. Med. Genet. 142 (2006) 40-51]. We have used real-time PCR to investigate changes in expression levels of three genes: WNT2, MECP2, and FMR1 in different brain regions of Fagile X mice and litter mate controls. We found major changes in the expression pattern for the three genes examined. FMR1, MECP2, and WNT2 expression were drastically down regulated in the Fragile X mouse brain. (C) 2009 Elsevier Inc. All rights reserved.

语种: 英语
项目资助者: China Scholar Council (CSC) ; The Fragile X Research Foundation (FRAXA) ; The College of Staten Island ; PSC-CUNY
WOS记录号: WOS:000263336700023
Citation statistics:
内容类型: 期刊论文
版本: 出版稿
URI标识: http://ir.bjmu.edu.cn/handle/400002259/52220
Appears in Collections:基础医学院_医学遗传学系_期刊论文

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作者单位: 1.CUNY, Dept Biol, Coll Staten Isl, Staten Isl, NY 10314 USA
2.Peking Univ, Dept Genet, Hlth Sci Ctr, Beijing 100083, Peoples R China
3.CUNY, Inst Mol Assemblies, Staten Isl, NY 10314 USA
4.New York State Inst Basic Res Dev Disabil, Dept Dev Neurobiol, Staten Isl, NY 10314 USA
5.Ctr Dev Neurosci, Staten Isl, NY 10314 USA

Recommended Citation:
Zhang, Aiying,Shen, Chang-Hui,Ma, Shuang Yong,et al. Altered expression of Autism-associated genes in the brain of Fragile X mouse model[J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,2009,379(4):920-923.
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