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学科主题: 临床医学
题名:
Effects of the NK cell recovery on outcomes of unmanipulated haploidentical blood and marrow transplantation for patients with hematologic malignancies
作者: Chang, Ying-Jun; Zhao, Xiang-Yu; Huang, Xiao-Jun
关键词: HLA-mismatched ; haploidentical ; HSCT ; GVHD ; CD56(bright) NK cells
刊名: BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION
发表日期: 2008-03-01
DOI: 10.1016/j.bbmt.2007.12.497
卷: 14, 期:3, 页:323-334
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Hematology ; Immunology ; Transplantation
研究领域[WOS]: Hematology ; Immunology ; Transplantation
关键词[WOS]: NATURAL-KILLER-CELLS ; VERSUS-HOST-DISEASE ; MATCHED SIBLING DONORS ; IMMUNE RECONSTITUTION ; GRAFT ; SUBSETS ; SUPPRESSION ; RECIPIENTS
英文摘要:

The goal of this study was to investigate the association of natural killer (N-K) cell recovery with clinical outcomes after unmanipulated haploidentical blood and marrow transplantation. We sequentially monitored the reconstitution kinetics of circulating N-K cells, CD56(bright) and CD56(dim), in 43 patients by flow cytometry, and the functionality recovery of cytokine or cytotoxicity of NK cells by flow cytometry or lactate dehydrogenase release assay after transplantation. Reconstitution of NK cells was rapid but accompanied by skewing of cell subsets bright mainly in CD56(bright), which recovered earlier. Linear regression analysis demonstrated that dose of CD34(+) cells in the allografts was inversely correlated with the ratio of T/NK cells (beta = -0.506, P = .003) and CD56(dim)/CD56(bright) cell (beta = -.403, P = .018) by day 14 after hematopoietic stem cell transplantation (HSCT), and the dose of CD3(+) T cells in the allografts was also inversely correlated with the ratio CD56(dim)/CD56(bright) cells by day 14 after HSCT (beta = -0.474, P = .005). Moreover, the dose of CD56(dim) NK cells in the allograft was positively associated with the day 14 CD56(bright) NK cells (beta = 0.494, P = .032) and inversely correlated with the day 14 ratio of CD56(dim)/CD56(bright) Cells (beta = -0.617, P = .005). Compared with nonacute graft-versus-host disease (GVHD) patients, patients with acute GVHD (aGVHD) had a higher level of NK subsets during week 2 post-transplantation. Cox regression analysis revealed that the patients with more CD56(bright) NK cells in the recovery stage had a higher survival rate (hazard risk [HR], 0.406; P = .017) and the patients with a higher ratio of T/NK (>1.0) had a higher chance of getting aGVHD (HR, 3.436; P = .059) and chronic GVHD (HR, 3.925; P = .028). Our results suggest that the recovery of NK cells is and can be used as an indicator to predicate the clinical outcomes after unmanipulated haploidentical transplantation. (C) 2008 American Society for Blood and Marrow Transplantation.

语种: 英语
WOS记录号: WOS:000253343500008
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/52227
Appears in Collections:北京大学第二临床医学院_血液科_期刊论文

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作者单位: Peking Univ, Inst Hematol, Peoples Hosp, Beijing 100044, Peoples R China

Recommended Citation:
Chang, Ying-Jun,Zhao, Xiang-Yu,Huang, Xiao-Jun. Effects of the NK cell recovery on outcomes of unmanipulated haploidentical blood and marrow transplantation for patients with hematologic malignancies[J]. BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION,2008,14(3):323-334.
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