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Microbial transformation of glycyrrhetinic acid by Mucor polymorphosporus
Xin, XL1; Liu, YF1; Ye, M1; Guo, HZ1; Guo, D1
关键词Microbial Transformation Glycyrrhetinic Acid Mucor Polymorphosporus Structural Identification
刊名PLANTA MEDICA
2006-02-01
DOI10.1055/s-2005-873198
72期:2页:156-161
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Plant Sciences ; Chemistry, Medicinal ; Pharmacology & Pharmacy
研究领域[WOS]Plant Sciences ; Pharmacology & Pharmacy
关键词[WOS]METABOLISM
英文摘要

Glycyrrhetinic acid (GA; 1) is one of the major constituents of a traditional Chinese medicine, the roots of Glycyrrhiza uralensis, called Gancao in Chinese. In the present paper, the biotransformation of GA by Mucor polymorphosporus (AS 3.3443) was investigated and eight metabolites were obtained. Based on their chemical and spectral data, the structures of the derivatives were respectively elucidated as 24-hydroxyglycyrrhetinic acid (2), 6 beta-hydroxyglycyrrhetinic acid (3), 7 alpha-hydroxyglycyrrhetinic acid (4), 7 beta-hydroxyglycyrrhetinic acid (5), 3-0-acetyl-7 beta-hydroxyglycyrrhetinic acid (6), 3-oxo-7 beta-liydroxyglycyrrhetinic acid (7), 15 alpha-hydroxyglycyrrhetinic acid (8), 3-oxo-15 alpha-hydroxyglycyrrhetinic acid (9), among which metabolites 3, 4, 6, 7 and 9 are new compounds.

语种英语
WOS记录号WOS:000235565300010
引用统计
被引频次:18[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/52229
专题北京大学药学院
北京大学药学院_天然药物学系
北京大学第三临床医学院_儿科
作者单位1.Peking Univ, State Key Lab Nat & Biomimet Drugs, Sch Pharmaceut Sci, Beijing 100083, Peoples R China
2.Beijing Vocat Coll Elect Sci & Technol, Biotechnol Applicat Ctr, Beijing, Peoples R China
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GB/T 7714
Xin, XL,Liu, YF,Ye, M,et al. Microbial transformation of glycyrrhetinic acid by Mucor polymorphosporus[J]. PLANTA MEDICA,2006,72(2):156-161.
APA Xin, XL,Liu, YF,Ye, M,Guo, HZ,&Guo, D.(2006).Microbial transformation of glycyrrhetinic acid by Mucor polymorphosporus.PLANTA MEDICA,72(2),156-161.
MLA Xin, XL,et al."Microbial transformation of glycyrrhetinic acid by Mucor polymorphosporus".PLANTA MEDICA 72.2(2006):156-161.
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