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学科主题: 药学
题名:
Microbial transformation of glycyrrhetinic acid by Mucor polymorphosporus
作者: Xin, XL1; Liu, YF1; Ye, M1; Guo, HZ1; Guo, D1
关键词: microbial transformation ; glycyrrhetinic acid ; Mucor polymorphosporus ; structural identification
刊名: PLANTA MEDICA
发表日期: 2006-02-01
DOI: 10.1055/s-2005-873198
卷: 72, 期:2, 页:156-161
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Plant Sciences ; Chemistry, Medicinal ; Pharmacology & Pharmacy
研究领域[WOS]: Plant Sciences ; Pharmacology & Pharmacy
关键词[WOS]: METABOLISM
英文摘要:

Glycyrrhetinic acid (GA; 1) is one of the major constituents of a traditional Chinese medicine, the roots of Glycyrrhiza uralensis, called Gancao in Chinese. In the present paper, the biotransformation of GA by Mucor polymorphosporus (AS 3.3443) was investigated and eight metabolites were obtained. Based on their chemical and spectral data, the structures of the derivatives were respectively elucidated as 24-hydroxyglycyrrhetinic acid (2), 6 beta-hydroxyglycyrrhetinic acid (3), 7 alpha-hydroxyglycyrrhetinic acid (4), 7 beta-hydroxyglycyrrhetinic acid (5), 3-0-acetyl-7 beta-hydroxyglycyrrhetinic acid (6), 3-oxo-7 beta-liydroxyglycyrrhetinic acid (7), 15 alpha-hydroxyglycyrrhetinic acid (8), 3-oxo-15 alpha-hydroxyglycyrrhetinic acid (9), among which metabolites 3, 4, 6, 7 and 9 are new compounds.

语种: 英语
WOS记录号: WOS:000235565300010
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/52229
Appears in Collections:北京大学药学院_期刊论文

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作者单位: 1.Peking Univ, State Key Lab Nat & Biomimet Drugs, Sch Pharmaceut Sci, Beijing 100083, Peoples R China
2.Beijing Vocat Coll Elect Sci & Technol, Biotechnol Applicat Ctr, Beijing, Peoples R China

Recommended Citation:
Xin, XL,Liu, YF,Ye, M,et al. Microbial transformation of glycyrrhetinic acid by Mucor polymorphosporus[J]. PLANTA MEDICA,2006,72(2):156-161.
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