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Primary antibiotic resistance of Helicobacter pylori strains isolated from patients with dyspeptic symptoms in Beijing: A prospective serial study
Zhang, Yue-Xi1; Zhou, Li-Ya2; Song, Zhi-Qiang2; Zhang, Jian-Zhong3; He, Li-Hua3; Ding, Yu2
关键词Helicobacter Pylori Antibiotic Resistance Beijing Dyspeptic Symptoms
刊名WORLD JOURNAL OF GASTROENTEROLOGY
2015-03-07
DOI10.3748/wjg.v21.i9.2786
21期:9页:2786-2792
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Gastroenterology & Hepatology
研究领域[WOS]Gastroenterology & Hepatology
关键词[WOS]STANDARD TRIPLE THERAPY ; SEQUENTIAL THERAPY ; RANDOMIZED-TRIAL ; CONSENSUS REPORT ; INFECTION ; ERADICATION ; AMOXICILLIN ; MULTICENTER ; MANAGEMENT ; 1ST-LINE
英文摘要

AIM: To determine the resistance patterns of Heli-cobacter pylori (H. pylori) strains isolated from patients in Beijing and monitor the change of antibiotic resistance over time.

METHODS: In this prospective, serial and cross-sectional study, H. pylori cultures were successfully obtained from 371 and 950 patients (never receiving eradication) during 2009-2010 and 2013-2014, respectively. Resistance to amoxicillin, clarithromycin, metronidazole, levofloxacin, tetracycline, and rifampicin was determined by Epsilometer test.

RESULTS: The resistance rates of isolates obtained during 2009-2010 were 66.8%, 39.9%, 34.5%, 15.4%, 6.7%, and 4.9% to metronidazole, clarithromycin, levofloxacin, rifampicin, amoxicillin and tetracycline, respectively; and the corresponding rates for isolates during 2013-2014 were 63.4%, 52.6%, 54.8%, 18.2%, 4.4% and 7.3%, respectively. The resistance rates to clarithromycin and levofloxacin were significantly increased after four years. In 2009-2010, 14.6% of H. pylori isolates were susceptible to all tested antibiotics, with mono (33.7%), double (28.3%), triple (16.7%), quadruple (6.2%), quintuple (0.3%) and sextuple resistance (0.3%) also being detected. In 2013-2014, 9.4% were susceptible to all tested antibiotics, and mono (27.6%), double (28.4%), triple (24.9%), quadruple (7.3%), quintuple (2.3%) and sextuple resistance (0.1%) was also observed. More multiple resistant H. pylori isolates were found during 2013-2014. Gender (to levofloxacin and metronidazole), age (to levofloxacin) and endoscopic findings (to clarithromycin) were independent factors influencing antibiotic resistance.

CONCLUSION: H. pylori resistance to commonly used antibiotics in Beijing is high with increased multiple antibiotic resistance.

语种英语
WOS记录号WOS:000350688400027
引用统计
被引频次:22[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/52230
专题北京大学第三临床医学院_肾内科
北京大学第三临床医学院_消化科
作者单位1.Beijing Sixth Hosp, Dept Gastroenterol, Beijing 100007, Peoples R China
2.Peking Univ, Hosp 3, Dept Gastroenterol, Beijing 100191, Peoples R China
3.Chinese Ctr Dis Control & Prevent, Natl Inst Communicable Dis Control & Prevent, State Key Lab Infect Dis Prevent & Control, Beijing 102206, Peoples R China
推荐引用方式
GB/T 7714
Zhang, Yue-Xi,Zhou, Li-Ya,Song, Zhi-Qiang,et al. Primary antibiotic resistance of Helicobacter pylori strains isolated from patients with dyspeptic symptoms in Beijing: A prospective serial study[J]. WORLD JOURNAL OF GASTROENTEROLOGY,2015,21(9):2786-2792.
APA Zhang, Yue-Xi,Zhou, Li-Ya,Song, Zhi-Qiang,Zhang, Jian-Zhong,He, Li-Hua,&Ding, Yu.(2015).Primary antibiotic resistance of Helicobacter pylori strains isolated from patients with dyspeptic symptoms in Beijing: A prospective serial study.WORLD JOURNAL OF GASTROENTEROLOGY,21(9),2786-2792.
MLA Zhang, Yue-Xi,et al."Primary antibiotic resistance of Helicobacter pylori strains isolated from patients with dyspeptic symptoms in Beijing: A prospective serial study".WORLD JOURNAL OF GASTROENTEROLOGY 21.9(2015):2786-2792.
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