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学科主题: 临床医学
题名:
Antifungal Activity of Geldanamycin Alone or in Combination with Fluconazole Against Candida species
作者: Zhang, Jinqing1,2; Liu, Wei1,2; Tan, Jingwen1,2; Sun, Yi1,2; Wan, Zhe1,2; Li, Ruoyu1,2
关键词: Antifungal activity ; Geldanamycin ; Fluconazole ; Candida species
刊名: MYCOPATHOLOGIA
发表日期: 2013-04-01
DOI: 10.1007/s11046-012-9612-1
卷: 175, 期:3-4, 页:273-279
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Mycology
研究领域[WOS]: Mycology
关键词[WOS]: DRUG-RESISTANCE ; IN-VITRO ; HSP90 ; ALBICANS ; MECHANISMS ; SUSCEPTIBILITY ; INFECTIONS ; GUIDELINES ; MANAGEMENT ; INHIBITOR
英文摘要:

A standardized broth microdilution method was used to test the antifungal activity of geldanamycin (GA), an inhibitor of heat shock protein 90 (Hsp90), alone or in combination with the antifungal agent fluconazole (FLC) against 32 clinical isolates of Candida spp. In addition, a disk diffusion test was also used to evaluate the antifungal effect of these two drugs against Candida spp. by measuring the inhibition zone diameters. We found that the range of minimal inhibitory concentrations (MICs) for GA alone against Candida spp. was 3.2-12.8 mg/L and the geometric mean of MICs was 6.54 mg/L. In addition, the combination of GA with FLC showed synergistic effects in vitro against 2 FLC-susceptible and 6 FLC-resistant isolates of C. albicans. As for the other isolates, indifference but no antagonism was observed. In the disk diffusion assay, the diameter of inhibition zones for FLC combined with GA against FLC-resistant C. albicans isolates was 30 mm, while no inhibition was observed with FLC alone. These results demonstrate that GA possesses antifungal activity against Candida spp., and the combination of GA with FLC shows in vitro synergistic activity against some C. albicans isolates, especially those resistant to FLC.

语种: 英语
所属项目编号: 30930006 ; 30970131 ; 7102149 ; NCET-10-0198 ; BMU20110158
项目资助者: National Natural Science Foundation of China ; Beijing Natural Science Foundation ; Program for New Century Excellent Talents in University
WOS记录号: WOS:000317623800009
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/52244
Appears in Collections:北京大学第一临床医学院_皮肤性病科_期刊论文

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作者单位: 1.Peking Univ, Hosp 1, Res Ctr Med Mycol, Dept Dermatol, Beijing 100034, Peoples R China
2.Peking Univ, Hosp 1, Res Ctr Med Mycol, Dept Dermatol & Venereol, Beijing 100034, Peoples R China

Recommended Citation:
Zhang, Jinqing,Liu, Wei,Tan, Jingwen,et al. Antifungal Activity of Geldanamycin Alone or in Combination with Fluconazole Against Candida species[J]. MYCOPATHOLOGIA,2013,175(3-4):273-279.
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