IR@PKUHSC  > 北京大学第一临床医学院  > 皮肤性病科
Antifungal Activity of Geldanamycin Alone or in Combination with Fluconazole Against Candida species
Zhang, Jinqing1,2; Liu, Wei1,2; Tan, Jingwen1,2; Sun, Yi1,2; Wan, Zhe1,2; Li, Ruoyu1,2
Source PublicationMYCOPATHOLOGIA
2013-04-01
Volume175Issue:3-4Pages:273-279
Indexed BySCI
Abstract

A standardized broth microdilution method was used to test the antifungal activity of geldanamycin (GA), an inhibitor of heat shock protein 90 (Hsp90), alone or in combination with the antifungal agent fluconazole (FLC) against 32 clinical isolates of Candida spp. In addition, a disk diffusion test was also used to evaluate the antifungal effect of these two drugs against Candida spp. by measuring the inhibition zone diameters. We found that the range of minimal inhibitory concentrations (MICs) for GA alone against Candida spp. was 3.2-12.8 mg/L and the geometric mean of MICs was 6.54 mg/L. In addition, the combination of GA with FLC showed synergistic effects in vitro against 2 FLC-susceptible and 6 FLC-resistant isolates of C. albicans. As for the other isolates, indifference but no antagonism was observed. In the disk diffusion assay, the diameter of inhibition zones for FLC combined with GA against FLC-resistant C. albicans isolates was 30 mm, while no inhibition was observed with FLC alone. These results demonstrate that GA possesses antifungal activity against Candida spp., and the combination of GA with FLC shows in vitro synergistic activity against some C. albicans isolates, especially those resistant to FLC.

KeywordAntifungal Activity Geldanamycin Fluconazole Candida Species
Subject Area临床医学
SubtypeArticle
DOI10.1007/s11046-012-9612-1
WOS HeadingsScience & Technology
Language英语
Funding OrganizationNational Natural Science Foundation of China ; Beijing Natural Science Foundation ; Program for New Century Excellent Talents in University
WOS Research AreaMycology
WOS SubjectMycology
WOS KeywordDRUG-RESISTANCE ; IN-VITRO ; HSP90 ; ALBICANS ; MECHANISMS ; SUSCEPTIBILITY ; INFECTIONS ; GUIDELINES ; MANAGEMENT ; INHIBITOR
WOS IDWOS:000317623800009
Citation statistics
Cited Times:11[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.bjmu.edu.cn/handle/400002259/52244
Collection北京大学第一临床医学院_皮肤性病科
北京大学第三临床医学院_药剂科
Affiliation1.Peking Univ, Hosp 1, Res Ctr Med Mycol, Dept Dermatol, Beijing 100034, Peoples R China
2.Peking Univ, Hosp 1, Res Ctr Med Mycol, Dept Dermatol & Venereol, Beijing 100034, Peoples R China
First Author AffilicationPEKING UNIVERSITY HEALTH SCIENCE CENTER
Recommended Citation
GB/T 7714
Zhang, Jinqing,Liu, Wei,Tan, Jingwen,et al. Antifungal Activity of Geldanamycin Alone or in Combination with Fluconazole Against Candida species[J]. MYCOPATHOLOGIA,2013,175(3-4):273-279.
APA Zhang, Jinqing,Liu, Wei,Tan, Jingwen,Sun, Yi,Wan, Zhe,&Li, Ruoyu.(2013).Antifungal Activity of Geldanamycin Alone or in Combination with Fluconazole Against Candida species.MYCOPATHOLOGIA,175(3-4),273-279.
MLA Zhang, Jinqing,et al."Antifungal Activity of Geldanamycin Alone or in Combination with Fluconazole Against Candida species".MYCOPATHOLOGIA 175.3-4(2013):273-279.
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