IR@PKUHSC  > 北京大学第一临床医学院  > 皮肤性病科
学科主题临床医学
Antifungal Activity of Geldanamycin Alone or in Combination with Fluconazole Against Candida species
Zhang, Jinqing1,2; Liu, Wei1,2; Tan, Jingwen1,2; Sun, Yi1,2; Wan, Zhe1,2; Li, Ruoyu1,2
关键词Antifungal Activity Geldanamycin Fluconazole Candida Species
刊名MYCOPATHOLOGIA
2013-04-01
DOI10.1007/s11046-012-9612-1
175期:3-4页:273-279
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Mycology
资助者National Natural Science Foundation of China ; Beijing Natural Science Foundation ; Program for New Century Excellent Talents in University ; National Natural Science Foundation of China ; Beijing Natural Science Foundation ; Program for New Century Excellent Talents in University
研究领域[WOS]Mycology
关键词[WOS]DRUG-RESISTANCE ; IN-VITRO ; HSP90 ; ALBICANS ; MECHANISMS ; SUSCEPTIBILITY ; INFECTIONS ; GUIDELINES ; MANAGEMENT ; INHIBITOR
英文摘要

A standardized broth microdilution method was used to test the antifungal activity of geldanamycin (GA), an inhibitor of heat shock protein 90 (Hsp90), alone or in combination with the antifungal agent fluconazole (FLC) against 32 clinical isolates of Candida spp. In addition, a disk diffusion test was also used to evaluate the antifungal effect of these two drugs against Candida spp. by measuring the inhibition zone diameters. We found that the range of minimal inhibitory concentrations (MICs) for GA alone against Candida spp. was 3.2-12.8 mg/L and the geometric mean of MICs was 6.54 mg/L. In addition, the combination of GA with FLC showed synergistic effects in vitro against 2 FLC-susceptible and 6 FLC-resistant isolates of C. albicans. As for the other isolates, indifference but no antagonism was observed. In the disk diffusion assay, the diameter of inhibition zones for FLC combined with GA against FLC-resistant C. albicans isolates was 30 mm, while no inhibition was observed with FLC alone. These results demonstrate that GA possesses antifungal activity against Candida spp., and the combination of GA with FLC shows in vitro synergistic activity against some C. albicans isolates, especially those resistant to FLC.

语种英语
所属项目编号30930006 ; 30970131 ; 7102149 ; NCET-10-0198 ; BMU20110158
资助者National Natural Science Foundation of China ; Beijing Natural Science Foundation ; Program for New Century Excellent Talents in University ; National Natural Science Foundation of China ; Beijing Natural Science Foundation ; Program for New Century Excellent Talents in University
WOS记录号WOS:000317623800009
引用统计
被引频次:8[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/52244
专题北京大学第一临床医学院_皮肤性病科
作者单位1.Peking Univ, Hosp 1, Res Ctr Med Mycol, Dept Dermatol, Beijing 100034, Peoples R China
2.Peking Univ, Hosp 1, Res Ctr Med Mycol, Dept Dermatol & Venereol, Beijing 100034, Peoples R China
推荐引用方式
GB/T 7714
Zhang, Jinqing,Liu, Wei,Tan, Jingwen,et al. Antifungal Activity of Geldanamycin Alone or in Combination with Fluconazole Against Candida species[J]. MYCOPATHOLOGIA,2013,175(3-4):273-279.
APA Zhang, Jinqing,Liu, Wei,Tan, Jingwen,Sun, Yi,Wan, Zhe,&Li, Ruoyu.(2013).Antifungal Activity of Geldanamycin Alone or in Combination with Fluconazole Against Candida species.MYCOPATHOLOGIA,175(3-4),273-279.
MLA Zhang, Jinqing,et al."Antifungal Activity of Geldanamycin Alone or in Combination with Fluconazole Against Candida species".MYCOPATHOLOGIA 175.3-4(2013):273-279.
条目包含的文件
条目无相关文件。
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[Zhang, Jinqing]的文章
[Liu, Wei]的文章
[Tan, Jingwen]的文章
百度学术
百度学术中相似的文章
[Zhang, Jinqing]的文章
[Liu, Wei]的文章
[Tan, Jingwen]的文章
必应学术
必应学术中相似的文章
[Zhang, Jinqing]的文章
[Liu, Wei]的文章
[Tan, Jingwen]的文章
相关权益政策
暂无数据
收藏/分享
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。