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A versatile synthesis of 17-heteroaryl androstenes via palladium-mediated Suzuki cross-coupling with heteroaryl boronic acids
Chao, Jianping1; Ling, Yangzhi1; Liu, Xiaofeng1; Luo, Xuande1; Brodie, A. M. H.1
关键词Suzuki Coupling Furanyl Or Thienyl bOronic Acids 17-iodoandrosta-5 Derivatives 16-dien-3 Beta-ol Or 4 16-dien-3-one 17-heteroaryl Androsta-5 16-diene-3 Beta-ol Or 4 16-dien-3-one
刊名STEROIDS
2006-07-01
DOI10.1016/j.steroids.2006.02.004
71期:7页:585-590
收录类别SCI ; IC ; CCR
文章类型Article
WOS标题词Science & Technology
类目[WOS]Biochemistry & Molecular Biology ; Endocrinology & Metabolism
研究领域[WOS]Biochemistry & Molecular Biology ; Endocrinology & Metabolism
关键词[WOS]PROSTATIC-CANCER ; 5-ALPHA-REDUCTASE INHIBITOR ; KETOCONAZOLE THERAPY ; STEROIDAL INHIBITORS ; POTENTIAL AGENTS ; BOND FORMATION ; P450(17-ALPHA) ; HETEROCYCLES ; DERIVATIVES ; FINASTERIDE
英文摘要

Suzuki coupling of 17-iodoandrosta-5,16-dien-3 beta-ol (1) and 17-iodoandrosta-4,16-dien-3-one (2) with nine heteroaryl boronic acids (mainly 2- or 3-furanyl, thienyl, benzofuranyl and benzothienyl boronic acid derivatives) were carried out under normal Suzuki condition (Pd(PPh3)(4), 2M Na2CO3 and MeOH), generally yielded C-17-heteroaryl steroids in moderate (10-60%) yields, but furanyl-2- and 5-chlorothienyl-2-boronic acid did not give any coupling product. (c) 2006 Elsevier Inc. All rights reserved.

语种英语
WOS记录号WOS:000238405800007
Citation statistics
Cited Times:12[WOS]   [WOS Record]     [Related Records in WOS]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/52247
Collection北京大学药学院_药物化学系
作者单位1.Natl Inst Pharmaceut Res & Dev, Beijing 100226, Peoples R China
2.Peking Univ, Sch Pharmaceut Sci, Dept Med Chem, Beijing 100083, Peoples R China
3.Beijing Inst Petrochem Technol, Sch Mat & Chem Engn, Beijing 102600, Peoples R China
4.Peking Univ, Sch Pharmaceut Sci, Beijing 100083, Peoples R China
5.Univ Maryland, Sch Med, Dept Pharmacol & Expt Therapeut, Baltimore, MD 21201 USA
Recommended Citation
GB/T 7714
Chao, Jianping,Ling, Yangzhi,Liu, Xiaofeng,et al. A versatile synthesis of 17-heteroaryl androstenes via palladium-mediated Suzuki cross-coupling with heteroaryl boronic acids[J]. STEROIDS,2006,71(7):585-590.
APA Chao, Jianping,Ling, Yangzhi,Liu, Xiaofeng,Luo, Xuande,&Brodie, A. M. H..(2006).A versatile synthesis of 17-heteroaryl androstenes via palladium-mediated Suzuki cross-coupling with heteroaryl boronic acids.STEROIDS,71(7),585-590.
MLA Chao, Jianping,et al."A versatile synthesis of 17-heteroaryl androstenes via palladium-mediated Suzuki cross-coupling with heteroaryl boronic acids".STEROIDS 71.7(2006):585-590.
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