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Functionalized PDMS with Versatile and Scalable Surface Roughness Gradients for Cell Culture
Zhou, Bingpu1,2,3; Gao, Xinghua5; Wang, Cong1,2; Ye, Ziran3; Gao, Yibo4; Xie, Jiao6; Wu, Xiaoxiao1; Wena, Weijia1,2,3,4,5,6
关键词Microfluidics Roughness Gradients Pdms N-isopropylacrylamide Cell Culture
刊名ACS APPLIED MATERIALS & INTERFACES
2015-08-12
DOI10.1021/acsami.5b04032
7期:31页:17181-17187
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary
研究领域[WOS]Science & Technology - Other Topics ; Materials Science
关键词[WOS]MICROFLUIDIC SYSTEMS ; NANOMETER-SCALE ; ADHESION ; POLY(DIMETHYLSILOXANE) ; WETTABILITY ; TOPOGRAPHY ; GENERATION ; OSTEOBLAST ; MORPHOLOGY ; INTERFACE
英文摘要

This manuscript describes a simple and versatile approach to engineering surface roughness gradients via combination of microfluidics and photopolymerization. Through UV-mediated polymerization, N-isopropylacrylamide with concentration gradients are successfully grafted onto PDMS surface, leading to diverse roughness degrees on the obtained PDMS substrate. Furthermore, the extent of surface roughness can be controllably regulated via tuning the flow rate ratio between the monomer solution and deionized water. Average roughness ranging from 2.6 +/- 0.7 nm to 163.6 +/- 11.7 nm has been well-achieved in this work. Such PDMS samples are also demonstrated to be capable of working as supporting substrates for controlling cell adhesion or detachment. Because of the different degrees of surface roughness on a single substrate, our method provides an effective approach for designing advanced surfaces for cell culture. Finally, the thermosensitive property of N-isopropylacrylamide makes our sample furnish as another means for controlling the cell detachment from the substrates with correspondence to the surrounding temperature.

语种英语
WOS记录号WOS:000359683600035
项目编号HKUST 605411 ; N_HKUST601/11 ; 201303045 ; 2014A030310422
资助机构Hong Kong RGC ; NSFC/RGC ; Ministry of Agriculture of the People&prime ; s Republic of China ; Natural Science Foundation of Guangdong Province
引用统计
被引频次:6[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/52248
专题北京大学深圳医院
作者单位1.Hong Kong Univ Sci & Technol, Nano Sci & Technol Program, Hong Kong, Hong Kong, Peoples R China
2.Hong Kong Univ Sci & Technol, KAUST HKUST Micro Nanofluid Joint Lab, Hong Kong, Hong Kong, Peoples R China
3.Hong Kong Univ Sci & Technol, Dept Phys, Hong Kong, Hong Kong, Peoples R China
4.Hong Kong Univ Sci & Technol, Environm Sci Programs, Sch Sci, Hong Kong, Hong Kong, Peoples R China
5.Shenzhen Peking Univ, Biomed Res Inst, Hong Kong Univ Sci & Technol, Med Ctr, Shenzhen, Peoples R China
6.Chongqing Univ, Soft Matter & Interdisciplinary Res Inst, Coll Phys, Chongqing 630044, Peoples R China
推荐引用方式
GB/T 7714
Zhou, Bingpu,Gao, Xinghua,Wang, Cong,et al. Functionalized PDMS with Versatile and Scalable Surface Roughness Gradients for Cell Culture[J]. ACS APPLIED MATERIALS & INTERFACES,2015,7(31):17181-17187.
APA Zhou, Bingpu.,Gao, Xinghua.,Wang, Cong.,Ye, Ziran.,Gao, Yibo.,...&Wena, Weijia.(2015).Functionalized PDMS with Versatile and Scalable Surface Roughness Gradients for Cell Culture.ACS APPLIED MATERIALS & INTERFACES,7(31),17181-17187.
MLA Zhou, Bingpu,et al."Functionalized PDMS with Versatile and Scalable Surface Roughness Gradients for Cell Culture".ACS APPLIED MATERIALS & INTERFACES 7.31(2015):17181-17187.
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