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学科主题: 临床医学
题名:
Functionalized PDMS with Versatile and Scalable Surface Roughness Gradients for Cell Culture
作者: Zhou, Bingpu1,2,3; Gao, Xinghua5; Wang, Cong1,2; Ye, Ziran3; Gao, Yibo4; Xie, Jiao6; Wu, Xiaoxiao1; Wena, Weijia1,2,3,4,5,6
关键词: microfluidics ; roughness gradients ; PDMS ; N-isopropylacrylamide ; cell culture
刊名: ACS APPLIED MATERIALS & INTERFACES
发表日期: 2015-08-12
DOI: 10.1021/acsami.5b04032
卷: 7, 期:31, 页:17181-17187
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary
研究领域[WOS]: Science & Technology - Other Topics ; Materials Science
关键词[WOS]: MICROFLUIDIC SYSTEMS ; NANOMETER-SCALE ; ADHESION ; POLY(DIMETHYLSILOXANE) ; WETTABILITY ; TOPOGRAPHY ; GENERATION ; OSTEOBLAST ; MORPHOLOGY ; INTERFACE
英文摘要:

This manuscript describes a simple and versatile approach to engineering surface roughness gradients via combination of microfluidics and photopolymerization. Through UV-mediated polymerization, N-isopropylacrylamide with concentration gradients are successfully grafted onto PDMS surface, leading to diverse roughness degrees on the obtained PDMS substrate. Furthermore, the extent of surface roughness can be controllably regulated via tuning the flow rate ratio between the monomer solution and deionized water. Average roughness ranging from 2.6 +/- 0.7 nm to 163.6 +/- 11.7 nm has been well-achieved in this work. Such PDMS samples are also demonstrated to be capable of working as supporting substrates for controlling cell adhesion or detachment. Because of the different degrees of surface roughness on a single substrate, our method provides an effective approach for designing advanced surfaces for cell culture. Finally, the thermosensitive property of N-isopropylacrylamide makes our sample furnish as another means for controlling the cell detachment from the substrates with correspondence to the surrounding temperature.

语种: 英语
所属项目编号: HKUST 605411 ; N_HKUST601/11 ; 201303045 ; 2014A030310422
项目资助者: Hong Kong RGC ; NSFC/RGC ; Ministry of Agriculture of the People&prime ; s Republic of China ; Natural Science Foundation of Guangdong Province
WOS记录号: WOS:000359683600035
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/52248
Appears in Collections:北京大学深圳医院_期刊论文

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作者单位: 1.Hong Kong Univ Sci & Technol, Nano Sci & Technol Program, Hong Kong, Hong Kong, Peoples R China
2.Hong Kong Univ Sci & Technol, KAUST HKUST Micro Nanofluid Joint Lab, Hong Kong, Hong Kong, Peoples R China
3.Hong Kong Univ Sci & Technol, Dept Phys, Hong Kong, Hong Kong, Peoples R China
4.Hong Kong Univ Sci & Technol, Environm Sci Programs, Sch Sci, Hong Kong, Hong Kong, Peoples R China
5.Shenzhen Peking Univ, Biomed Res Inst, Hong Kong Univ Sci & Technol, Med Ctr, Shenzhen, Peoples R China
6.Chongqing Univ, Soft Matter & Interdisciplinary Res Inst, Coll Phys, Chongqing 630044, Peoples R China

Recommended Citation:
Zhou, Bingpu,Gao, Xinghua,Wang, Cong,et al. Functionalized PDMS with Versatile and Scalable Surface Roughness Gradients for Cell Culture[J]. ACS APPLIED MATERIALS & INTERFACES,2015,7(31):17181-17187.
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