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Supraomohyoid neck dissection and modified radical neck dissection for clinically node-negative oral squamous cell carcinoma: A prospective study of prognosis, complications and quality of life
Bin Guo, Chuan; Feng, Zhien; Zhang, Jian Guo; Peng, Xin; Cai, Zhi Gang; Mao, Chi; Zhang, Yi; Yu, Guang Yan; Li, Jian Nan; Niu, Li Xuan
关键词Oral Squamous Cell Carcinoma Neck Dissection Prognosis Complication Quality Of Life
刊名JOURNAL OF CRANIO-MAXILLOFACIAL SURGERY
2014-12-01
DOI10.1016/j.jcms.2014.07.007
42期:8页:1885-1890
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Dentistry, Oral Surgery & Medicine ; Surgery
资助者National Natural Science Foundation of China ; Beijing Municipal Natural Science Foundation ; National High Technology Research and Development Program of China ; China Postdoctoral Science Foundation ; National Natural Science Foundation of China ; Beijing Municipal Natural Science Foundation ; National High Technology Research and Development Program of China ; China Postdoctoral Science Foundation
研究领域[WOS]Dentistry, Oral Surgery & Medicine ; Surgery
关键词[WOS]SELECTIVE NECK ; MANAGEMENT ; CANCER ; METASTASES ; TONGUE ; HEAD
英文摘要

Background: To assess the prognosis and morbidity between supraomohyoid neck dissection (SOND) and modified radical neck dissection (MRND) for oral squamous cell carcinoma (OSCC) in patients with a clinically node-negative neck (cN0).

Patients and methods: This prospective randomized study began in June 1999, and patient accrual concluded in May 2010. The cN0 neck was confirmed on clinical palpation by senior doctors. Ultimately, there were 322 patients recruited into the study.

Results: Patient demographics were well balanced between the two groups. There were 10 patients in the SOND group and 21 patients in the MRND group who developed nodal recurrence without associated local recurrence or distant metastasis. The 3-year neck control rate (NCR) rate was 92.6% for the SOND group and 87.5% for the MRND group (in favor of SOND, P = 0.108). There was no significant difference between the SOND group and the MRND group in the 3-year disease-specific survival (DSS) rate (79.0% vs. 76.9%, P = 0.659). Importantly, there were significantly fewer complications in the SOND group compared with the MRND group (13.0% vs. 21.9%, P = 0.040). The disease-free survivors in the SOND group also reported better pain relief (P = 0.013) and shoulder function (P < 0.001) than those in the MRND group one year after treatment.

Conclusions: We recommend SOND as a priority treatment for cN0 OSCC patients. (C) 2014 European Association for Cranio-Maxillo-Facial Surgery. Published by Elsevier Ltd. All rights reserved.

语种英语
所属项目编号81302350 ; 7144258 ; 2009AA045201 ; 2014T70018
资助者National Natural Science Foundation of China ; Beijing Municipal Natural Science Foundation ; National High Technology Research and Development Program of China ; China Postdoctoral Science Foundation ; National Natural Science Foundation of China ; Beijing Municipal Natural Science Foundation ; National High Technology Research and Development Program of China ; China Postdoctoral Science Foundation
WOS记录号WOS:000346833200056
引用统计
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/52249
专题北京大学口腔医学院
作者单位Peking Univ, Dept Oral & Maxillofacial Surg, Sch Stomatol, Beijing 100081, Peoples R China
推荐引用方式
GB/T 7714
Bin Guo, Chuan,Feng, Zhien,Zhang, Jian Guo,et al. Supraomohyoid neck dissection and modified radical neck dissection for clinically node-negative oral squamous cell carcinoma: A prospective study of prognosis, complications and quality of life[J]. JOURNAL OF CRANIO-MAXILLOFACIAL SURGERY,2014,42(8):1885-1890.
APA Bin Guo, Chuan.,Feng, Zhien.,Zhang, Jian Guo.,Peng, Xin.,Cai, Zhi Gang.,...&Niu, Li Xuan.(2014).Supraomohyoid neck dissection and modified radical neck dissection for clinically node-negative oral squamous cell carcinoma: A prospective study of prognosis, complications and quality of life.JOURNAL OF CRANIO-MAXILLOFACIAL SURGERY,42(8),1885-1890.
MLA Bin Guo, Chuan,et al."Supraomohyoid neck dissection and modified radical neck dissection for clinically node-negative oral squamous cell carcinoma: A prospective study of prognosis, complications and quality of life".JOURNAL OF CRANIO-MAXILLOFACIAL SURGERY 42.8(2014):1885-1890.
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