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学科主题临床医学
Ex vivo converted double negative T cells suppress activated B cells
Li WenXia1; Tian Yue2; Li Zhao1; Gao Jie1; Shi Wen2; Zhu JiYe1; Zhang Dong2
关键词Cd4(-)Cd8(-) Double Negative t Cells b Cells Immune Suppression Perforin
刊名INTERNATIONAL IMMUNOPHARMACOLOGY
2014-05-01
DOI10.1016/j.intimp.2014.02.034
20期:1页:164-169
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Immunology ; Pharmacology & Pharmacy
研究领域[WOS]Immunology ; Pharmacology & Pharmacy
关键词[WOS]REGULATORY CELLS ; IMMUNE-RESPONSES ; IN-VIVO ; PERFORIN ; PATHWAY ; TOLERANCE ; NKG2D ; DEATH ; TRANSPLANTATION ; IDENTIFICATION
英文摘要

Although the ability of endogenous CD4(-)CD8(-) double negative (DN) T cells to suppress B cells has been documented, the extent to which ex vivo converted DN T cells suppress B cells activity is still being explored. The aim of this study was to determine whether and what extent ex vivo converted CD4(-)CD8(-) DN T cells suppress B cell activation and antibody production. We found that ex vivo converted ON T cells suppressed proliferation of activated B cells in a perforin and cell-cell contact dependent manner. In addition, ex vivo converted DN T cells significantly inhibited the production of IgG by stimulated B cells. This study provides evidence that ex vivo converted CD4(-)CD8(-) double negative T cells can down-regulate immune responses by suppressing B cell proliferation and IgG production, and supports efforts to develop ex vivo DNT cell therapies. (C) 2014 Elsevier B.V. All rights reserved.

语种英语
WOS记录号WOS:000336337900022
引用统计
被引频次:6[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/52250
专题北京大学第二临床医学院_肝胆外科
北京大学基础医学院
作者单位1.Peking Univ, Dept Hepatobiliary Surg, Peoples Hosp, Beijing 100044, Peoples R China
2.Capital Med Univ, Res Ctr, Beijing Friendship Hosp, Beijing 100050, Peoples R China
推荐引用方式
GB/T 7714
Li WenXia,Tian Yue,Li Zhao,et al. Ex vivo converted double negative T cells suppress activated B cells[J]. INTERNATIONAL IMMUNOPHARMACOLOGY,2014,20(1):164-169.
APA Li WenXia.,Tian Yue.,Li Zhao.,Gao Jie.,Shi Wen.,...&Zhang Dong.(2014).Ex vivo converted double negative T cells suppress activated B cells.INTERNATIONAL IMMUNOPHARMACOLOGY,20(1),164-169.
MLA Li WenXia,et al."Ex vivo converted double negative T cells suppress activated B cells".INTERNATIONAL IMMUNOPHARMACOLOGY 20.1(2014):164-169.
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