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IR@PKUHSC  > 北京大学第二临床医学院  > 肝胆外科  > 期刊论文
学科主题: 临床医学
题名:
Ex vivo converted double negative T cells suppress activated B cells
作者: Li WenXia1; Tian Yue2; Li Zhao1; Gao Jie1; Shi Wen2; Zhu JiYe1; Zhang Dong2
关键词: CD4(-)CD8(-) double negative T cells ; B cells ; Immune suppression ; Perforin
刊名: INTERNATIONAL IMMUNOPHARMACOLOGY
发表日期: 2014-05-01
DOI: 10.1016/j.intimp.2014.02.034
卷: 20, 期:1, 页:164-169
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Immunology ; Pharmacology & Pharmacy
研究领域[WOS]: Immunology ; Pharmacology & Pharmacy
关键词[WOS]: REGULATORY CELLS ; IMMUNE-RESPONSES ; IN-VIVO ; PERFORIN ; PATHWAY ; TOLERANCE ; NKG2D ; DEATH ; TRANSPLANTATION ; IDENTIFICATION
英文摘要:

Although the ability of endogenous CD4(-)CD8(-) double negative (DN) T cells to suppress B cells has been documented, the extent to which ex vivo converted DN T cells suppress B cells activity is still being explored. The aim of this study was to determine whether and what extent ex vivo converted CD4(-)CD8(-) DN T cells suppress B cell activation and antibody production. We found that ex vivo converted ON T cells suppressed proliferation of activated B cells in a perforin and cell-cell contact dependent manner. In addition, ex vivo converted DN T cells significantly inhibited the production of IgG by stimulated B cells. This study provides evidence that ex vivo converted CD4(-)CD8(-) double negative T cells can down-regulate immune responses by suppressing B cell proliferation and IgG production, and supports efforts to develop ex vivo DNT cell therapies. (C) 2014 Elsevier B.V. All rights reserved.

语种: 英语
WOS记录号: WOS:000336337900022
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/52250
Appears in Collections:北京大学第二临床医学院_肝胆外科_期刊论文

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作者单位: 1.Peking Univ, Dept Hepatobiliary Surg, Peoples Hosp, Beijing 100044, Peoples R China
2.Capital Med Univ, Res Ctr, Beijing Friendship Hosp, Beijing 100050, Peoples R China

Recommended Citation:
Li WenXia,Tian Yue,Li Zhao,et al. Ex vivo converted double negative T cells suppress activated B cells[J]. INTERNATIONAL IMMUNOPHARMACOLOGY,2014,20(1):164-169.
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