IR@PKUHSC  > 北京大学第一临床医学院
学科主题临床医学
Prenatal diagnostic testing among women referred for advanced maternal age in Beijing, 2001-2012
Ma, Jingmei; Hong, Pan; Fu, Jie; Yu, Li; Yang, Huixia
关键词Advanced Maternal Age Amniocentesis Cytogenetic Indication Prenatal Diagnosis
刊名INTERNATIONAL JOURNAL OF GYNECOLOGY & OBSTETRICS
2014-06-01
DOI10.1016/j.ijgo.2013.12.004
125期:3页:232-236
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Obstetrics & Gynecology
研究领域[WOS]Obstetrics & Gynecology
关键词[WOS]DOWN-SYNDROME ; PREGNANT-WOMEN ; 1ST-TRIMESTER ; TRENDS ; POLICY
英文摘要

Objective: To determine the proportion of women with advanced maternal age (AMA) undergoing amniocentesis and assess the recommended indication of 35 years or older in China. Methods: Data were retrospectively evaluated from 9641 patients who underwent diagnostic prenatal amniocentesis in Beijing, China, between January 2001 and December 2012. Maternal age, indication for testing, and karyotype data were collected. Patients referred for AMA were stratified in 2 ways: 35-37 years, 38-40 years, and 41 years or older; and indication of AMA alone or combined with other screening. Outcomes and safety performance were compared among the groups. Results: From 2001 to 2012, the annual rate of amniocentesis and the proportion of AMA-related indications increased (P < 0.01). Overall, 82 abnormalities were detected. In the AMA group, the spontaneous abortion rate was 0.5% (22/4748). The positive predictive value (PPV) of AMA alone was 0.5% for women aged 35-37 years. Only among women aged 41 years or older was the PPV of AMA alone better than that of AMA plus other indications (2.3% vs 1.5%, respectively). Conclusion: The PPV of 35 years or older did not offset the risk of spontaneous abortion. AMA alone should not be used as an indication for amniocentesis especially among women aged 35-40 years. (C) 2014 International Federation of Gynecology and Obstetrics. Published by Elsevier Ireland Ltd. All rights reserved.

语种英语
WOS记录号WOS:000337658300008
Citation statistics
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/52255
Collection北京大学第一临床医学院
作者单位Peking Univ, Hosp 1, Cytogenet Lab, Dept Obstet & Gynecol, Beijing 100034, Peoples R China
Recommended Citation
GB/T 7714
Ma, Jingmei,Hong, Pan,Fu, Jie,et al. Prenatal diagnostic testing among women referred for advanced maternal age in Beijing, 2001-2012[J]. INTERNATIONAL JOURNAL OF GYNECOLOGY &amp; OBSTETRICS,2014,125(3):232-236.
APA Ma, Jingmei,Hong, Pan,Fu, Jie,Yu, Li,&Yang, Huixia.(2014).Prenatal diagnostic testing among women referred for advanced maternal age in Beijing, 2001-2012.INTERNATIONAL JOURNAL OF GYNECOLOGY & OBSTETRICS,125(3),232-236.
MLA Ma, Jingmei,et al."Prenatal diagnostic testing among women referred for advanced maternal age in Beijing, 2001-2012".INTERNATIONAL JOURNAL OF GYNECOLOGY & OBSTETRICS 125.3(2014):232-236.
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