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学科主题: 临床医学
题名:
Antigen and epitope specificity of anti-glomerular basement membrane antibodies in patients with Goodpasture disease with or without anti-neutrophil cytoplasmic antibodies
作者: Yang, Rui1; Hellmark, Thomas1; Zhao, Juan1; Cui, Zhao1; Segelmark, Marten1; Zhao, Ming-hui1; Wang, Hai-yan1
刊名: JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
发表日期: 2007-04-01
DOI: 10.1681/ASN.2006111210
卷: 18, 期:4, 页:1338-1343
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Urology & Nephrology
研究领域[WOS]: Urology & Nephrology
关键词[WOS]: GBM ANTIBODIES ; MEDIATED GLOMERULONEPHRITIS ; SEQUENTIAL DEVELOPMENT ; ALPHA-3(IV) COLLAGEN ; CHINESE PATIENTS ; NC1 DOMAIN ; AUTOANTIBODIES ; IDENTIFICATION ; ANCA ; IV
英文摘要:

Goodpasture disease (GP) is defined by the presence of anti-glomerular basement membrane (anti-GBM) antibodies and rapidly progressive glomerulonephritis. Besides anti-GBM, many patients with GP produce anti-neutrophil cytoplasmic antibodies (ANCA). For elucidation of the pathophysiologic significance of ANCA in this setting, epitope and antigen specificity of the anti-GBM antibodies and antigen specificity of ANCA were studied. Bovine testis a(IV)NC1 (tNC1); recombinant human alpha 1, alpha 3, alpha 4, and alpha 5(IV)NC1 (r alpha 1 through r alpha 5); and three chimeric proteins that contain previously defined epitope regions designated E-A, E-B, and S2 were used to examine the anti-GBM antibodies by ELISA in 205 Chinese patients with GP with or without ANCA. In the 205 anti-GBM antibody-positive sera, 63 (30.7%) were also ANCA positive (61 myeloperoxidase-ANCA and six proteinase 3-ANCA, four being triple positive). All 205 sera recognized tNC1 and r alpha 3(IV)NC1. In the double-positive group, 54.0, 66.7, 71.4% of the sera could recognize r alpha 1, r alpha 4, and r alpha 5, respectively, compared with 49.3, 60.6, and 55.6% for patients with anti-GBM antibodies alone. The levels of the antibodies to r alpha 3, tNC1, and the alpha 3/alpha 1 ratio were lower in the double-positive group than that in patients with anti-GBM antibody alone (P < 0.05). Most of the sera could recognize the epitope regions E-A,E-B, and S2, but the absorbance values to EA, EB, and S2 were lower in double-positive group (P < 0.05). Double-positive patients had a broader spectrum of anti-GBM antibodies and lower levels of antibodies against alpha 3(IV)NC1 compared with that of patients with anti-GBM antibodies alone.

语种: 英语
WOS记录号: WOS:000245524300036
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/52273
Appears in Collections:北京大学第一临床医学院_肾脏内科_期刊论文

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作者单位: 1.Minist Hlth China, Key Lab Renal Dis, Beijing, Peoples R China
2.Lund Univ, Dept Nephrol, Clin Sci, Lund, Sweden
3.Peking Univ, Dept Med, Div Renal, Inst Nephrol,Peking Univ First Hosp, Beijing 100034, Peoples R China

Recommended Citation:
Yang, Rui,Hellmark, Thomas,Zhao, Juan,et al. Antigen and epitope specificity of anti-glomerular basement membrane antibodies in patients with Goodpasture disease with or without anti-neutrophil cytoplasmic antibodies[J]. JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY,2007,18(4):1338-1343.
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