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学科主题: 临床医学
题名:
The Expression and Clinical Significance of Different Forms of Mer Receptor Tyrosine Kinase in Systemic Lupus Erythematosus
作者: Zhu, Huaqun; Sun, Xiaolin; Zhu, Lei; Hu, Fanlei; Shi, Lianjie; Li, Zhanguo; Su, Yin
刊名: JOURNAL OF IMMUNOLOGY RESEARCH
发表日期: 2014
DOI: 10.1155/2014/431896
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Immunology
研究领域[WOS]: Immunology
关键词[WOS]: APOPTOTIC CELL CLEARANCE ; HUMAN MACROPHAGES ; TAM RECEPTORS ; B-CELL ; C-MER ; PHAGOCYTOSIS ; DISEASE ; MICE ; AXL ; GLUCOCORTICOIDS
英文摘要:

Objective. To investigate the expression and clinical significance of trans-membrane MerTK (mMer) on circulating CD14+ monocytes/macrophages and soluble MerTK (sMer) levels in plasma in systemic lupus erythematosus (SLE). Method. 108 SLE patients and 42 healthy controls were recruited in this study. The expression of mMer on the surfaces of CD14+ monocytes/macrophages was evaluated by flow cytometry (FCM). The sMer levels were measured by ELISA. Real-time quantitative PCR was applied to evaluate the mRNA levels of MerTK and ADAM17. Results. Both mMer expression on CD14+ monocytes/macrophages and sMer levels in plasma significantly increased in SLE patients compared to healthy subjects. The frequency of anti-inflammatory MerTK expressing CD14+ CD16+ monocytes decreased in SLE. mMer expression was positively correlated with CD163 expression on CD14+ cells. Both the mMer expression on CD14+ monocytes/macrophages and sMer levels in plasma were positively correlated with SLEDAI. Furthermore, more elevated mMer and sMer levels were found in patients with higher SLEDAI, presence of anti-SSA, anti-Sm autoantibodies, and lupus nephritis. Conclusion. Both mMer and sMer levels significantly increased in SLE and positively correlated with disease activity and severity. The upregulation of MerTK expression may serve as a biomarker of the disease activity and severity of SLE.

语种: 英语
所属项目编号: 81172844 ; 2010CB529104
项目资助者: Natural Science Foundation of China ; National Basic Research Program of China (973 program)
WOS记录号: WOS:000333689500001
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/52274
Appears in Collections:北京大学第二临床医学院_期刊论文

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作者单位: Peking Univ, Peoples Hosp, Dept Rheumatol & Immunol, Beijing 100044, Peoples R China

Recommended Citation:
Zhu, Huaqun,Sun, Xiaolin,Zhu, Lei,et al. The Expression and Clinical Significance of Different Forms of Mer Receptor Tyrosine Kinase in Systemic Lupus Erythematosus[J]. JOURNAL OF IMMUNOLOGY RESEARCH,2014.
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