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The Expression and Clinical Significance of Different Forms of Mer Receptor Tyrosine Kinase in Systemic Lupus Erythematosus
Zhu, Huaqun; Sun, Xiaolin; Zhu, Lei; Hu, Fanlei; Shi, Lianjie; Li, Zhanguo; Su, Yin
刊名JOURNAL OF IMMUNOLOGY RESEARCH
2014
DOI10.1155/2014/431896
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Immunology
研究领域[WOS]Immunology
关键词[WOS]APOPTOTIC CELL CLEARANCE ; HUMAN MACROPHAGES ; TAM RECEPTORS ; B-CELL ; C-MER ; PHAGOCYTOSIS ; DISEASE ; MICE ; AXL ; GLUCOCORTICOIDS
英文摘要

Objective. To investigate the expression and clinical significance of trans-membrane MerTK (mMer) on circulating CD14+ monocytes/macrophages and soluble MerTK (sMer) levels in plasma in systemic lupus erythematosus (SLE). Method. 108 SLE patients and 42 healthy controls were recruited in this study. The expression of mMer on the surfaces of CD14+ monocytes/macrophages was evaluated by flow cytometry (FCM). The sMer levels were measured by ELISA. Real-time quantitative PCR was applied to evaluate the mRNA levels of MerTK and ADAM17. Results. Both mMer expression on CD14+ monocytes/macrophages and sMer levels in plasma significantly increased in SLE patients compared to healthy subjects. The frequency of anti-inflammatory MerTK expressing CD14+ CD16+ monocytes decreased in SLE. mMer expression was positively correlated with CD163 expression on CD14+ cells. Both the mMer expression on CD14+ monocytes/macrophages and sMer levels in plasma were positively correlated with SLEDAI. Furthermore, more elevated mMer and sMer levels were found in patients with higher SLEDAI, presence of anti-SSA, anti-Sm autoantibodies, and lupus nephritis. Conclusion. Both mMer and sMer levels significantly increased in SLE and positively correlated with disease activity and severity. The upregulation of MerTK expression may serve as a biomarker of the disease activity and severity of SLE.

语种英语
WOS记录号WOS:000333689500001
项目编号81172844 ; 2010CB529104
资助机构Natural Science Foundation of China ; National Basic Research Program of China (973 program)
引用统计
被引频次:8[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/52274
专题北京大学第二临床医学院
北京大学第二临床医学院_风湿免疫科
作者单位Peking Univ, Peoples Hosp, Dept Rheumatol & Immunol, Beijing 100044, Peoples R China
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GB/T 7714
Zhu, Huaqun,Sun, Xiaolin,Zhu, Lei,et al. The Expression and Clinical Significance of Different Forms of Mer Receptor Tyrosine Kinase in Systemic Lupus Erythematosus[J]. JOURNAL OF IMMUNOLOGY RESEARCH,2014.
APA Zhu, Huaqun.,Sun, Xiaolin.,Zhu, Lei.,Hu, Fanlei.,Shi, Lianjie.,...&Su, Yin.(2014).The Expression and Clinical Significance of Different Forms of Mer Receptor Tyrosine Kinase in Systemic Lupus Erythematosus.JOURNAL OF IMMUNOLOGY RESEARCH.
MLA Zhu, Huaqun,et al."The Expression and Clinical Significance of Different Forms of Mer Receptor Tyrosine Kinase in Systemic Lupus Erythematosus".JOURNAL OF IMMUNOLOGY RESEARCH (2014).
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