北京大学医学部机构知识库
Advanced  
IR@PKUHSC  > 北京大学药学院  > 天然药物学系  > 期刊论文
学科主题: 药学
题名:
Intestinal Permeability of Antitumor Alkaloids from the Processed Seeds of Strychnos nux-vomica in a Caco-2 Cell Model
作者: Ma, Lian1,2; Yang, Xiu-Wei1,2; Xu, Wei1,2; Cai, Bao-Chang3; Hattori, Masao4
关键词: Strychnos nux-vomica ; Loganiaceae ; strychnos alkaloids ; intestinal permeability ; Caco-2 cell model
刊名: PLANTA MEDICA
发表日期: 2009-05-01
DOI: 10.1055/s-0029-1185387
卷: 75, 期:6, 页:631-634
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Plant Sciences ; Chemistry, Medicinal ; Pharmacology & Pharmacy
研究领域[WOS]: Plant Sciences ; Pharmacology & Pharmacy
关键词[WOS]: ABSORPTION ; TRANSPORT
英文摘要:

The uptake and intestinal permeability of the seven alkaloids strychnine (Str), brucine (Bru), beta-colubrine (Col), strychnine N-oxide (S-N), brucine N-oxide (B-N), pseudostrychnine (Psd), and icajine (Ica), which were isolated from the processed seeds of Strychnos nux-vomica L., were investigated in the human intestinal Caco-2 model. Determination of compounds was carried out by HPLC. The apparent permeability coefficients (P(app)) for Str, Bru, Col, S-N, B-N, Psd, and Ica in the apical-to-basolateral direction were (3.11 +/- 0.17) X 10(-5), (1.67 +/- 0.65) x 10(-5), (2.67 +/- 0.30) X 10(-5), (0.17 +/- 0.01) x 10(-5), (0.35 +/- 0.02) X 10(-5), (2.51 +/- 0.33) x 10(-5), and (2.61 +/- 0.34) x 10(-5) cm/s, respectively. In the concentration range of 10-200 mu M, Str, Bru, Col, and Psd showed substantial concentration-dependent transport across the monolayers. The transports of all seven alkaloids were linear with time and showed moderate to high permeabilities. In the presence of 2,4-dinitrophenol or sodium azide, the P(app) of Ica was reduced significantly in both the apical-to-basolateral and basolateral-to-apical directions. The dominant mechanism of the intestinal absorption for Str, Bru, Col, S-N, B-N, and Psd was passive diffusion, while it was partially ATP dependent for Ica.

语种: 英语
所属项目编号: 2002AA2Z343C ; 2004AA2Z3783 ; 2006BA106A01-02 ; Z0004105040311
项目资助者: National High Technology Research and Development Program of China ; Beijing Municipal Special Purpose Science Foundation of China
WOS记录号: WOS:000266381500013
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/52275
Appears in Collections:北京大学药学院_天然药物学系_期刊论文

Files in This Item:

There are no files associated with this item.


作者单位: 1.Nanjing Univ Tradit Chinese Med, Nanjing, Peoples R China
2.Toyama Univ, Inst Nat Med, Div Metab Engn, Toyama 930, Japan
3.Peking Univ, State Key Lab Nat & Biomimet Drugs, Beijing 100191, Peoples R China
4.Peking Univ, Sch Pharmaceut Sci, Dept Nat Med, Beijing 100191, Peoples R China

Recommended Citation:
Ma, Lian,Yang, Xiu-Wei,Xu, Wei,et al. Intestinal Permeability of Antitumor Alkaloids from the Processed Seeds of Strychnos nux-vomica in a Caco-2 Cell Model[J]. PLANTA MEDICA,2009,75(6):631-634.
Service
Recommend this item
Sava as my favorate item
Show this item's statistics
Export Endnote File
Google Scholar
Similar articles in Google Scholar
[Ma, Lian]'s Articles
[Yang, Xiu-Wei]'s Articles
[Xu, Wei]'s Articles
CSDL cross search
Similar articles in CSDL Cross Search
[Ma, Lian]‘s Articles
[Yang, Xiu-Wei]‘s Articles
[Xu, Wei]‘s Articles
Related Copyright Policies
Null
Social Bookmarking
Add to CiteULike Add to Connotea Add to Del.icio.us Add to Digg Add to Reddit
所有评论 (0)
暂无评论
 
评注功能仅针对注册用户开放,请您登录
您对该条目有什么异议,请填写以下表单,管理员会尽快联系您。
内 容:
Email:  *
单位:
验证码:   刷新
您在IR的使用过程中有什么好的想法或者建议可以反馈给我们。
标 题:
 *
内 容:
Email:  *
验证码:   刷新

Items in IR are protected by copyright, with all rights reserved, unless otherwise indicated.

 

 

Valid XHTML 1.0!
Copyright © 2007-2017  北京大学医学部 - Feedback
Powered by CSpace