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Metabolic studies on the total phenolic acids from the roots of Salivia miltiorrhiza in rats
Zhang, JL1; He, Y1; Cui, M1; Li, L1; Yu, HL1; Zhang, GF1; Guo, D1
关键词Salvia Miltiorrhiza Total Phenolic Acids Metabolisms Hplc-uv And Hplc-ms Analysis
刊名BIOMEDICAL CHROMATOGRAPHY
2005
DOI10.1002/bmc.415
19期:1页:51-59
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Biochemical Research Methods ; Biochemistry & Molecular Biology ; Chemistry, Analytical ; Pharmacology & Pharmacy
研究领域[WOS]Biochemistry & Molecular Biology ; Chemistry ; Pharmacology & Pharmacy
英文摘要

Phenolic acids are the main active constituents of Salvia miltiorrhiza Bunge. The metabolism of total phenolic acids from the roots of Salvia miltiorrhiza in rats was investigated. A sample preparation method combining the solid-phase extraction with liquid-liquid extraction was established to separate metabolites from the biological matrix. HPLC-UV and HPLC-MS methods were employed to analyze the metabolites. Five metabolites (M1-M5) were identified by HPLC-MS analysis and comparison with those of the reference standards. The five metabolites were characterized as danshensu (M1), caffeic acid (M2), ferulic acid (M3), isoferulic acid (M4) and methylized ferulic acid (M5), respectively. The possible metabolic pathway of the phenolic acids is proposed. Copyright (C) 2004 John Wiley Sons, Ltd.

语种英语
WOS记录号WOS:000227233400009
引用统计
被引频次:30[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/52276
专题北京大学药学院
北京大学第一临床医学院_医疗耗材科
作者单位1.Peking Univ, Sch Pharmaceut Sci, Beijing 100083, Peoples R China
2.Peking Univ, Modern Res Ctr Tradit Chinese Med, Beijing 100083, Peoples R China
3.Chinese Acad Sci, Inst Proc Engn, Beijing 100080, Peoples R China
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GB/T 7714
Zhang, JL,He, Y,Cui, M,et al. Metabolic studies on the total phenolic acids from the roots of Salivia miltiorrhiza in rats[J]. BIOMEDICAL CHROMATOGRAPHY,2005,19(1):51-59.
APA Zhang, JL.,He, Y.,Cui, M.,Li, L.,Yu, HL.,...&Guo, D.(2005).Metabolic studies on the total phenolic acids from the roots of Salivia miltiorrhiza in rats.BIOMEDICAL CHROMATOGRAPHY,19(1),51-59.
MLA Zhang, JL,et al."Metabolic studies on the total phenolic acids from the roots of Salivia miltiorrhiza in rats".BIOMEDICAL CHROMATOGRAPHY 19.1(2005):51-59.
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