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学科主题: 药学
题名:
Metabolic studies on the total phenolic acids from the roots of Salivia miltiorrhiza in rats
作者: Zhang, JL1; He, Y1; Cui, M1; Li, L1; Yu, HL1; Zhang, GF1; Guo, D1
关键词: Salvia miltiorrhiza ; total phenolic acids ; metabolisms ; HPLC-UV and HPLC-MS analysis
刊名: BIOMEDICAL CHROMATOGRAPHY
发表日期: 2005
DOI: 10.1002/bmc.415
卷: 19, 期:1, 页:51-59
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Biochemical Research Methods ; Biochemistry & Molecular Biology ; Chemistry, Analytical ; Pharmacology & Pharmacy
研究领域[WOS]: Biochemistry & Molecular Biology ; Chemistry ; Pharmacology & Pharmacy
英文摘要:

Phenolic acids are the main active constituents of Salvia miltiorrhiza Bunge. The metabolism of total phenolic acids from the roots of Salvia miltiorrhiza in rats was investigated. A sample preparation method combining the solid-phase extraction with liquid-liquid extraction was established to separate metabolites from the biological matrix. HPLC-UV and HPLC-MS methods were employed to analyze the metabolites. Five metabolites (M1-M5) were identified by HPLC-MS analysis and comparison with those of the reference standards. The five metabolites were characterized as danshensu (M1), caffeic acid (M2), ferulic acid (M3), isoferulic acid (M4) and methylized ferulic acid (M5), respectively. The possible metabolic pathway of the phenolic acids is proposed. Copyright (C) 2004 John Wiley Sons, Ltd.

语种: 英语
WOS记录号: WOS:000227233400009
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/52276
Appears in Collections:北京大学药学院_期刊论文

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作者单位: 1.Peking Univ, Sch Pharmaceut Sci, Beijing 100083, Peoples R China
2.Peking Univ, Modern Res Ctr Tradit Chinese Med, Beijing 100083, Peoples R China
3.Chinese Acad Sci, Inst Proc Engn, Beijing 100080, Peoples R China

Recommended Citation:
Zhang, JL,He, Y,Cui, M,et al. Metabolic studies on the total phenolic acids from the roots of Salivia miltiorrhiza in rats[J]. BIOMEDICAL CHROMATOGRAPHY,2005,19(1):51-59.
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