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学科主题: 临床医学
题名:
Expression of oncogenic HMGN5 increases the sensitivity of prostate cancer cells to gemcitabine
作者: Guo, Zhongqiang1; Zhang, Xiaoyu1; Li, Xuesong1; Xie, Feng1; Su, Boxing1; Zhang, Min1; Zhou, Liqun1,2
关键词: prostate cancer ; HMGN5 ; gemcitabine ; biomarker ; MAPK pathway
刊名: ONCOLOGY REPORTS
发表日期: 2015-03-01
DOI: 10.3892/or.2014.3696
卷: 33, 期:3, 页:1519-1525
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Oncology
研究领域[WOS]: Oncology
关键词[WOS]: NUCLEOSOMAL BINDING-PROTEIN ; PHASE-II TRIAL ; CARCINOMA-CELLS ; IN-VITRO ; TRANSCRIPTION ; VARIANTS ; RECEPTOR ; GROWTH ; NSBP1 ; GENE
英文摘要:

Prostate cancer is a leading cause of cancer-related death among men. Early diagnosis and treatment are successful against prostate cancer, yet the clinical treatment of advanced prostate cancer remains a challenge. Gemcitabine is used to treat a broad spectrum of solid tumors; however, the clinical response of prostate cancer patients to gemcitabine is limited. In the present study, we showed that HMGN5, a nucleosome binding protein that can unfold chromatin by binding to histone (H1), is overexpressed in prostate cancer cells and plays an oncogenic role in prostate cancer tumorigenesis and development by activating the MAPK signaling pathway. We also found that sensitivity of prostate cancer cells to gemcitabine was positively correlated with HMGN5 expression. Knockdown of HMGN5 expression reduced the sensitivity of PC-3 cells to gemcitabine, and ectopic HMGN5 expression in DU145 cells enhanced the sensitivity to gemcitabine. Gemcitabine decreased HMGN5 expression, consequently leading to inactivation of the MAPK signaling pathway and cleavage of the PARP protein. Finally, we showed that PC-3 cells acquire gemcitabine resistance by gradual loss of HMGN5 expression. The present study suggests that HMGN5 is a potential biomarker for treating prostate cancer, and patients with a high level HMGN5 will benefit from gemcitabine treatment.

语种: 英语
所属项目编号: 30672099 ; 7122183
项目资助者: National Natural Science Foundation of China ; Beijing National Science Foundation of China
WOS记录号: WOS:000349735800065
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/52277
Appears in Collections:北京大学第一临床医学院_泌尿外科_期刊论文

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作者单位: 1.Peking Univ, Hosp 1, Dept Urol, Beijing 100034, Peoples R China
2.Peking Univ, Inst Urol, Beijing 100034, Peoples R China

Recommended Citation:
Guo, Zhongqiang,Zhang, Xiaoyu,Li, Xuesong,et al. Expression of oncogenic HMGN5 increases the sensitivity of prostate cancer cells to gemcitabine[J]. ONCOLOGY REPORTS,2015,33(3):1519-1525.
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