IR@PKUHSC  > 北京大学基础医学院  > 病理学系
学科主题基础医学
Frequent epigenetic silencing of protocadherin 10 by methylation in multiple haematologic malignancies
Ying, Jianming1; Gao, Zifen1; Li, Hongyu1; Srivastava, Gopesh1; Murray, Paul G.1; Goh, Hwee Koon1; Lim, Chai Yen1; Wang, Yajun1; Marafioti, Teresa1; Mason, David Y.1; Ambinder, Richard F.1; Chan, Anthony T. C.1; Tao, Qian1
关键词PCDH10 methylation lymphoma biomarker tumour suppressor gene
刊名BRITISH JOURNAL OF HAEMATOLOGY
2007-03-01
DOI10.1111/j.1365-2141.2007.06512.x
136期:6页:829-832
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Hematology
研究领域[WOS]Hematology
关键词[WOS]CANDIDATE TUMOR-SUPPRESSOR ; GENE ; HYPERMETHYLATION ; LEUKEMIA ; CANCERS
英文摘要

Epigenetic silencing of tumour suppressor genes (TSG) inactivates TSG functions. Previously, we identified PCDH10 as a methylated TSG in carcinomas. Here, we detected its frequent silencing and methylation in lymphoma cell lines including 100% Burkitt, 100% diffuse large B cell, 86% Hodgkin, 100% nasal natural killer/T-cell lymphoma and 1/3 of leukaemia cell lines, and in primary tumours but not in normal peripheral blood mononuclear cells or lymph nodes. PCDH10 silencing could be reversed by demethylation with 5-aza-2′-deoxycytidine. Methylation was further detected in 14% of Hodgkin lymphoma sera. Thus, PCDH10 methylation is frequently involved in lymphomagenesis and could serve as a tumour-specific biomarker.

语种英语
WOS记录号WOS:000244611600007
Citation statistics
Cited Times:42[WOS]   [WOS Record]     [Related Records in WOS]
文献类型期刊论文
版本出版稿
条目标识符http://ir.bjmu.edu.cn/handle/400002259/52280
Collection北京大学基础医学院_病理学系
作者单位1.Univ Oxford, Nuffield Dept Clin Lab Sci, Oxford, England
2.John Hopkins Singapore, Biopolis, Singapore, Singapore
3.Chinese Univ Hong Kong, Sir YK Pao Ctr Canc, Dept Clin Oncol,Hong Kong Canc Inst, PWH,Canc Epigenet Lab,State Key Lab Oncol S China, Shatin, Hong Kong, Peoples R China
4.Chinese Univ Hong Kong, Li Ka Shing Inst Hlth Sci, Shatin, Hong Kong, Peoples R China
5.Peking Univ, Dept Pathol, Hlth Sci Ctr, Beijing 100871, Peoples R China
6.Univ Hong Kong, Dept Pathol, Hong Kong, Hong Kong, Peoples R China
7.Univ Birmingham, CRUK Inst Canc Studies, Birmingham, W Midlands, England
8.Johns Hopkins Sch Med, Sydney Kimmel Comprehens Canc Ctr, Baltimore, MD USA
Recommended Citation
GB/T 7714
Ying, Jianming,Gao, Zifen,Li, Hongyu,et al. Frequent epigenetic silencing of protocadherin 10 by methylation in multiple haematologic malignancies[J]. BRITISH JOURNAL OF HAEMATOLOGY,2007,136(6):829-832.
APA Ying, Jianming.,Gao, Zifen.,Li, Hongyu.,Srivastava, Gopesh.,Murray, Paul G..,...&Tao, Qian.(2007).Frequent epigenetic silencing of protocadherin 10 by methylation in multiple haematologic malignancies.BRITISH JOURNAL OF HAEMATOLOGY,136(6),829-832.
MLA Ying, Jianming,et al."Frequent epigenetic silencing of protocadherin 10 by methylation in multiple haematologic malignancies".BRITISH JOURNAL OF HAEMATOLOGY 136.6(2007):829-832.
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