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学科主题: 基础医学
题名:
Frequent epigenetic silencing of protocadherin 10 by methylation in multiple haematologic malignancies
作者: Ying, Jianming1; Gao, Zifen1; Li, Hongyu1; Srivastava, Gopesh1; Murray, Paul G.1; Goh, Hwee Koon1; Lim, Chai Yen1; Wang, Yajun1; Marafioti, Teresa1; Mason, David Y.1; Ambinder, Richard F.1; Chan, Anthony T. C.1; Tao, Qian1
关键词: PCDH10 ; methylation ; lymphoma ; biomarker ; tumour suppressor gene
刊名: BRITISH JOURNAL OF HAEMATOLOGY
发表日期: 2007-03-01
DOI: 10.1111/j.1365-2141.2007.06512.x
卷: 136, 期:6, 页:829-832
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Hematology
研究领域[WOS]: Hematology
关键词[WOS]: CANDIDATE TUMOR-SUPPRESSOR ; GENE ; HYPERMETHYLATION ; LEUKEMIA ; CANCERS
英文摘要:

Epigenetic silencing of tumour suppressor genes (TSG) inactivates TSG functions. Previously, we identified PCDH10 as a methylated TSG in carcinomas. Here, we detected its frequent silencing and methylation in lymphoma cell lines including 100% Burkitt, 100% diffuse large B cell, 86% Hodgkin, 100% nasal natural killer/T-cell lymphoma and 1/3 of leukaemia cell lines, and in primary tumours but not in normal peripheral blood mononuclear cells or lymph nodes. PCDH10 silencing could be reversed by demethylation with 5-aza-2′-deoxycytidine. Methylation was further detected in 14% of Hodgkin lymphoma sera. Thus, PCDH10 methylation is frequently involved in lymphomagenesis and could serve as a tumour-specific biomarker.

语种: 英语
WOS记录号: WOS:000244611600007
Citation statistics:
内容类型: 期刊论文
版本: 出版稿
URI标识: http://ir.bjmu.edu.cn/handle/400002259/52280
Appears in Collections:基础医学院_病理学系_期刊论文

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作者单位: 1.Univ Oxford, Nuffield Dept Clin Lab Sci, Oxford, England
2.John Hopkins Singapore, Biopolis, Singapore, Singapore
3.Chinese Univ Hong Kong, Sir YK Pao Ctr Canc, Dept Clin Oncol,Hong Kong Canc Inst, PWH,Canc Epigenet Lab,State Key Lab Oncol S China, Shatin, Hong Kong, Peoples R China
4.Chinese Univ Hong Kong, Li Ka Shing Inst Hlth Sci, Shatin, Hong Kong, Peoples R China
5.Peking Univ, Dept Pathol, Hlth Sci Ctr, Beijing 100871, Peoples R China
6.Univ Hong Kong, Dept Pathol, Hong Kong, Hong Kong, Peoples R China
7.Univ Birmingham, CRUK Inst Canc Studies, Birmingham, W Midlands, England
8.Johns Hopkins Sch Med, Sydney Kimmel Comprehens Canc Ctr, Baltimore, MD USA

Recommended Citation:
Ying, Jianming,Gao, Zifen,Li, Hongyu,et al. Frequent epigenetic silencing of protocadherin 10 by methylation in multiple haematologic malignancies[J]. BRITISH JOURNAL OF HAEMATOLOGY,2007,136(6):829-832.
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