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学科主题基础医学
Increased plasma levels of intermedin and brain natriuretic peptide associated with severity of coronary stenosis in acute coronary syndrome
Qin, Yan-Wen1; Teng, Xu2,4; He, Ji-Qiang1; Du, Jie1; Tang, Chao-Shu1; Qi, Yong-Fen1,3
关键词Acute Coronary Syndrome Intermedin Brain Natriuretic Peptide
刊名PEPTIDES
2013-04-01
DOI10.1016/j.peptides.2013.01.011
42页:84-88
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Biochemistry & Molecular Biology ; Pharmacology & Pharmacy
资助者National Natural Science Foundation of China ; Program for Changjiang Scholars and Innovative Research Team in University ; International Science &amp ; Technology Cooperation Program of China ; National Natural Science Foundation of China ; Program for Changjiang Scholars and Innovative Research Team in University ; International Science &amp ; Technology Cooperation Program of China
研究领域[WOS]Biochemistry & Molecular Biology ; Pharmacology & Pharmacy
关键词[WOS]SPONTANEOUSLY HYPERTENSIVE-RATS ; ELEVATION MYOCARDIAL-INFARCTION ; COUNTER-REGULATORY PEPTIDE ; CONGESTIVE-HEART-FAILURE ; PROGNOSTIC VALUE ; UNSTABLE ANGINA ; CARDIOVASCULAR EVENTS ; OXIDATIVE STRESS ; EXPRESSION ; BIOMARKERS
英文摘要

Intermedin (IMD) is a newly discovered peptide with increased levels in plasma and cardiac tissue in mice with ischemia/reperfusion. Continuous administration of low dose IMD markedly elevated the mRNA abundance of myocardial BNP in rats. Plasma BNP levels may reflect the severity of degree of coronary stenosis in patients with acute coronary syndrome (ACS). However, the role of circulating IMD in coronary heart disease remains unclear. We aimed to examine the plasma content of IMD and brain natriuretic peptide (BNP) and its clinical significance in patients with ACS. We collected plasma samples from 41 patients with ACS and 31 controls and measured IMD and BNP levels by radioimmunoassay. The severity of coronary artery stenosis for patients with ACS was measured by coronary angiography. Plasma IMD and BNP levels were markedly higher in ACS patients than that in controls (P<0.05). The increased plasma IMD and BNP were positively correlated with degree of coronary stenosis in ACS patients (r=0.263 and r=0.238, respectively, both P<0.05). In addition, plasma levels of IMD were positively correlated with BNP levels. (C) 2013 Elsevier Inc. All rights reserved.

语种英语
所属项目编号81070251 ; 81100222 ; 81270389 ; 81170082 ; IRT1074 ; 2010DFB30040
资助者National Natural Science Foundation of China ; Program for Changjiang Scholars and Innovative Research Team in University ; International Science &amp ; Technology Cooperation Program of China ; National Natural Science Foundation of China ; Program for Changjiang Scholars and Innovative Research Team in University ; International Science &amp ; Technology Cooperation Program of China
WOS记录号WOS:000320492800012
引用统计
被引频次:14[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/52284
专题基础医学院_心血管所
作者单位1.Hebei Key Lab Lab Anim Sci, Shijiazhuang 050017, Hebei, Peoples R China
2.Capital Med Univ, Key Lab Remodeling Related Cardiovasc Dis, Beijing Inst Heart Lung & Blood Vessel Dis, Beijing An Zhen Hosp,Minist Educ, Beijing 100029, Peoples R China
3.Hebei Med Univ, Dept Physiol, Shijiazhuang 050017, Peoples R China
4.Peking Univ, Hlth Sci Ctr, Minist Educ, Key Lab Mol Cardiovasc Sci, Beijing 100191, Peoples R China
推荐引用方式
GB/T 7714
Qin, Yan-Wen,Teng, Xu,He, Ji-Qiang,et al. Increased plasma levels of intermedin and brain natriuretic peptide associated with severity of coronary stenosis in acute coronary syndrome[J]. PEPTIDES,2013,42:84-88.
APA Qin, Yan-Wen,Teng, Xu,He, Ji-Qiang,Du, Jie,Tang, Chao-Shu,&Qi, Yong-Fen.(2013).Increased plasma levels of intermedin and brain natriuretic peptide associated with severity of coronary stenosis in acute coronary syndrome.PEPTIDES,42,84-88.
MLA Qin, Yan-Wen,et al."Increased plasma levels of intermedin and brain natriuretic peptide associated with severity of coronary stenosis in acute coronary syndrome".PEPTIDES 42(2013):84-88.
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